DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Insr and Eph

DIOPT Version :9

Sequence 1:NP_001316985.1 Gene:Insr / 16337 MGIID:96575 Length:1384 Species:Mus musculus
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1021 Identity:250/1021 - (24%)
Similarity:383/1021 - (37%) Gaps:308/1021 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse   490 GDQASCENELLKFSFIRTSFDKILLRWEPYWPPD------------------------------- 523
            |:..||:.   .||.:...|| ...|..|.|..|                               
  Fly   172 GNALSCKE---TFSLLFYEFD-AATREPPPWQTDSYRLIARIAAGEGRFNQNSDVDINTEVKSIA 232

Mouse   524 ---------FRD------LLGFMLFYKEAP--YQNVTEFD----GQD--ACGSNSWTVVDIDPPQ 565
                     |||      :|...::|...|  .:|...|:    |::  .....:.|.||...|.
  Fly   233 VNKKGVYFAFRDQGACISVLAVKVYYITCPAVTENFAHFNETPTGREITIIEKQNGTCVDNAEPY 297

Mouse   566 RSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN------- 623
            .:          |.:|.:|...||..               |.|.:....| :.:.||       
  Fly   298 ET----------PTYLCKGDGKWTIL---------------TGGCRCKAGY-EPNYTNKTCTECP 336

Mouse   624 ------PSV----PLDPISVSNSSSQIILK-----------------WKPPSDPNGNITHYLVYW 661
                  |.|    |..|.|.::.:.....|                 :.||:.|. |:|...|  
  Fly   337 LGTFKSPEVTKCTPCPPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPT-NLTLLFV-- 398

Mouse   662 ERQAEDSELFELDYCLKGLKLPSRTWSPP-----FESDDSQK--HNQSEYDDSASECCSC----- 714
               .:.|.:.              :||.|     |.|:.:.|  |:...|   ..:|..|     
  Fly   399 ---DQTSAII--------------SWSAPAKNESFSSETNSKIYHSDIVY---KIKCNICSPNVV 443

Mouse   715 --PKTDS-----QILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNV 772
              |.||:     ..|..||..:   |:...:|.:       :|.:...:.:......||..|.::
  Fly   444 YNPSTDTFNETKITLTNLEPVT---TYTVQIHAI-------NSVSHINEFKRHSNESSLVAVSDI 498

Mouse   773 TATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCS 837
            ..:..:|.:.| :....|.|.|.     |.|...||:::|     |.:.:.:.|......|    
  Fly   499 VFSNTSLLNIP-LDLNEVKTGQA-----EIVFTTESVLLS-----TVFNLRILAITNKDAD---- 548

Mouse   838 VAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV 902
                                             |.|.:|.:.:..:..|||  |.:...||....
  Fly   549 ---------------------------------LEWDKPVQSDFPLEFYEV--RWFPKVELDAIN 578

Mouse   903 SRKHFALERGCRLRGLSPG-NYSVRVRATSLAGNGSWTEPTYFYV--------TDYLDVPSNIAK 958
            .......|....:.||... .|..:||..:..|.||::...|...        .|.:.: ..||.
  Fly   579 KSALNTKETKAHIVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQI-RFIAG 642

Mouse   959 IIIGPLIFVFLFSVVIGSIYLFLRKRQPDG---------PMGPLYASSNPEYLSASDVFP----- 1009
            .|:..::|:.:|  :|.::| |:|.:..|.         |:...|||:.   :::.|..|     
  Fly   643 AIVTGVLFLVIF--IIATVY-FMRSKHQDDLDKKSTNHLPLPLDYASNE---VNSMDTTPIVKKL 701

Mouse  1010 -----------SSVYV-PDEWEVPREK------------ITLLRELGQGSFGMVYEGNAKDIIKG 1050
                       |..|| |..:|.|.:.            ||:...:|.|.||.|..|..|.....
  Fly   702 HLNVTTPLFGNSRSYVDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNF 766

Mouse  1051 EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1115
            ..:..||:||:...:|.:.|.:||.|||:|..|...:|:.|.|||::..|.:::.|.|.:|.|.:
  Fly   767 VQDIDVAIKTLKPGSSEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDT 831

Mouse  1116 HLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF 1180
            .||.       |.|: ..||| :|.|...||.||:||:...:|||||||||.:|......||.||
  Fly   832 FLRV-------NDGK-FQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADF 887

Mouse  1181 GMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLS 1243
            |::|:|....  |..:|||  :||||.:||::....||::||:||:||||||:.|..|:||...|
  Fly   888 GLSREIENASDAYTTRGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWS 950

Mouse  1244 NEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDL----------HP 1298
            |:.|:|.:..|..|..|.:|||.|..||..|||.....||||..||:.| |:|          .|
  Fly   951 NQDVIKSIEKGYRLPAPMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL-DNLARQPQSLLTTRP 1014

Mouse  1299 SFPEVSFFYSEENKAPESEELEMEFED----MENVPLDRSSHCQRE 1340
            | ||     |:.|...:.:..:..|..    :|::.:.|..|..:|
  Fly  1015 S-PE-----SDGNHILDGQRGQNIFISTDLWLEHIKMSRYCHHFKE 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InsrNP_001316985.1 Recep_L_domain 52..164 CDD:279382
Furin-like 179..337 CDD:279142
FU 234..281 CDD:238021
Recep_L_domain 359..472 CDD:279382
FN3 624..>667 CDD:238020 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 688..709 7/27 (26%)
Insulin-binding. /evidence=ECO:0000250 735..743 1/7 (14%)
FN3 869..946 CDD:238020 19/77 (25%)
Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250 998..1001 0/2 (0%)
PTKc_InsR 1018..1305 CDD:133192 121/310 (39%)
Pkinase_Tyr 1025..1292 CDD:285015 112/268 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1361..1384
PIK3R1 binding. /evidence=ECO:0000250 1363..1366
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 16/91 (18%)
FN3 387..476 CDD:238020 24/121 (20%)
FN3 536..623 CDD:238020 21/125 (17%)
EphA2_TM 644..736 CDD:291255 20/97 (21%)
PTKc_EphR 736..1002 CDD:270629 114/277 (41%)
Pkinase_Tyr 741..999 CDD:285015 112/268 (42%)
SAM_1 1033..1092 CDD:278937 5/22 (23%)
SAM 1039..1092 CDD:197735 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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