Sequence 1: | NP_001316985.1 | Gene: | Insr / 16337 | MGIID: | 96575 | Length: | 1384 | Species: | Mus musculus |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_524625.3 | Gene: | Eph / 43803 | FlyBaseID: | FBgn0025936 | Length: | 1096 | Species: | Drosophila melanogaster |
Alignment Length: | 1021 | Identity: | 250/1021 - (24%) |
---|---|---|---|
Similarity: | 383/1021 - (37%) | Gaps: | 308/1021 - (30%) |
- Green bases have known domain annotations that are detailed below.
Mouse 490 GDQASCENELLKFSFIRTSFDKILLRWEPYWPPD------------------------------- 523
Mouse 524 ---------FRD------LLGFMLFYKEAP--YQNVTEFD----GQD--ACGSNSWTVVDIDPPQ 565
Mouse 566 RSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN------- 623
Mouse 624 ------PSV----PLDPISVSNSSSQIILK-----------------WKPPSDPNGNITHYLVYW 661
Mouse 662 ERQAEDSELFELDYCLKGLKLPSRTWSPP-----FESDDSQK--HNQSEYDDSASECCSC----- 714
Mouse 715 --PKTDS-----QILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNV 772
Mouse 773 TATTLTLPDFPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCS 837
Mouse 838 VAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCV 902
Mouse 903 SRKHFALERGCRLRGLSPG-NYSVRVRATSLAGNGSWTEPTYFYV--------TDYLDVPSNIAK 958
Mouse 959 IIIGPLIFVFLFSVVIGSIYLFLRKRQPDG---------PMGPLYASSNPEYLSASDVFP----- 1009
Mouse 1010 -----------SSVYV-PDEWEVPREK------------ITLLRELGQGSFGMVYEGNAKDIIKG 1050
Mouse 1051 EAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKS 1115
Mouse 1116 HLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF 1180
Mouse 1181 GMTRDIYETD--YYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAEQPYQGLS 1243
Mouse 1244 NEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDL----------HP 1298
Mouse 1299 SFPEVSFFYSEENKAPESEELEMEFED----MENVPLDRSSHCQRE 1340 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Insr | NP_001316985.1 | Recep_L_domain | 52..164 | CDD:279382 | |
Furin-like | 179..337 | CDD:279142 | |||
FU | 234..281 | CDD:238021 | |||
Recep_L_domain | 359..472 | CDD:279382 | |||
FN3 | 624..>667 | CDD:238020 | 12/63 (19%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 688..709 | 7/27 (26%) | |||
Insulin-binding. /evidence=ECO:0000250 | 735..743 | 1/7 (14%) | |||
FN3 | 869..946 | CDD:238020 | 19/77 (25%) | ||
Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250 | 998..1001 | 0/2 (0%) | |||
PTKc_InsR | 1018..1305 | CDD:133192 | 121/310 (39%) | ||
Pkinase_Tyr | 1025..1292 | CDD:285015 | 112/268 (42%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1361..1384 | ||||
PIK3R1 binding. /evidence=ECO:0000250 | 1363..1366 | ||||
Eph | NP_524625.3 | EphR_LBD | 85..260 | CDD:198439 | 16/91 (18%) |
FN3 | 387..476 | CDD:238020 | 24/121 (20%) | ||
FN3 | 536..623 | CDD:238020 | 21/125 (17%) | ||
EphA2_TM | 644..736 | CDD:291255 | 20/97 (21%) | ||
PTKc_EphR | 736..1002 | CDD:270629 | 114/277 (41%) | ||
Pkinase_Tyr | 741..999 | CDD:285015 | 112/268 (42%) | ||
SAM_1 | 1033..1092 | CDD:278937 | 5/22 (23%) | ||
SAM | 1039..1092 | CDD:197735 | 4/16 (25%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.910 |