DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Insr and Sdr

DIOPT Version :9

Sequence 1:	NP_001316985.1	Gene:	Insr / 16337	MGIID:	96575	Length:	1384	Species:	Mus musculus
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	263/946 - (27%)
Similarity:	411/946 - (43%)	Gaps:	217/946 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse    11 AVPLLVAVAALLVGTAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71
            ||||::    |.:|.:..:....    .|..::| |.:..|.:|:||:.:.||:::..:
  Fly    18 AVPLIL----LFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71

Mouse    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136

Mouse   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDVCPGTA 190
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||
  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193

Mouse   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHKECLGNC 243
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254

Mouse   244 SEPDDPTKCVACRNFYLDGQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHN 308
            ...:    |..|.|:.....||..|... |.....||:....|::|      .|.|     :|..
  Fly   255 YSQN----CSLCANYQGRMGCVNQCVAS-YELNKRRCIGHRECREL------GRIP-----LIRG 303

Mouse   309 NKCIPECPSGYTMNSSNLMCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLII---N 370
            .:|:.:||.    |...::....:..|...|   .|:..:.|....:.|:.|..|||||.|   |
  Fly   304 YQCVKKCPG----NQKEILVAKGIIHCQVEC---NGDFHVKSAADLEVLQDCVTINGSLTIELTN 361

Mouse   371 IRGGNNLAAELEANLGLIEEISGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNL 435
            |:  ..:...||..|..::||:|:||:..|..|:||:|.:.|..|||:.|....|:.|.::|.:|
  Fly   362 IK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNNYHL 424

Mouse   436 RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN--- 497
            ..:|. ..|.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:
  Fly   425 EHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGDAVR 488

Mouse   498 ------ELLKFSFIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSW 556
                  |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.::|
  Fly   489 SLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGHDNW 546

Mouse   557 TVVDIDPPQRSNDPKSQTPSHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDA 621
             ::|:.|        :|:..|   ::.||||:||||.||||| |.::......|.|.|.|.||..
  Fly   547 -LMDVVP--------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTLP 598

Mouse   622 TNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWERQAEDSELFELDYCLKGLKLPSRT 686
            ..||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.
  Fly   599 DRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV---------- 653

Mouse   687 WSPPFESDDSQKHNQSEYDDSASECCSC---------PKTDSQILKELEESSFRK---TFEDYLH 739
                    :.:..|..:.|      |.|         |:.|       :|..:.|   |:||.|.
  Fly   654 --------NVELENAKDID------CECAGVLPYYSGPQPD-------DEDYYNKEQITYEDALP 697

Mouse   740 NVVFVPRK-----------------TSSGNGAEDSRP---------------------------- 759
            |:::|.|.                 .|.....|.:||
  Fly   698 NLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRLN 762

Mouse   760 -SRKRRSLEEVGNVTATTL-TLPDFPNVSSTIVPTSQEEHRPFEKVVNKESL---VISGLRHF-- 817
             .:|:|.|:::.....|.. .||...|..:::|  .|.|    ||.|.:|.|   .:.|.:||
  Fly   763 SEKKQRDLQDLDQHKYTIRHALPKCQNSHASVV--QQVE----EKCVAEEPLSGYELPGTQHFYC 821

Mouse   818 -------TGYRIELQACNQDSPDERCSVAAYVSART 846
                   |.|||.::|| .:.....||..|....:|
  Fly   822 LSQLEPETHYRITIRAC-VEGVVNGCSTPAEAVIKT 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Insr	NP_001316985.1	Recep_L_domain	52..164	CDD:279382	44/120 (37%)
		Furin-like	179..337	CDD:279142	39/169 (23%)
		FU	234..281	CDD:238021	12/46 (26%)
		Recep_L_domain	359..472	CDD:279382	45/115 (39%)
		FN3	624..>667	CDD:238020	19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	688..709		2/20 (10%)
		Insulin-binding. /evidence=ECO:0000250	735..743		4/7 (57%)
		FN3	869..946	CDD:238020
		Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250	998..1001
		PTKc_InsR	1018..1305	CDD:133192
		Pkinase_Tyr	1025..1292	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1361..1384
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	44/120 (37%)
		Furin-like	209..332	CDD:279142	36/145 (25%)
		Recep_L_domain	347..461	CDD:279382	45/116 (39%)
		FN3	491..578	CDD:214495	39/106 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8331
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820