Protein Alignment GBP6 and gbp2

DIOPT Version :10

• Sequence 1: NP_940862.2
• Gene: GBP6 / 163351
• HGNCID: 25395
• Length: 633
• Species: Homo sapiens
• Sequence 2: XP_699217.3
• Gene: gbp2 / 570622
• ZFINID: ZDB-GENE-070912-618
• Length: 625
• Species: Danio rerio
• Alignment Length: 630
• Identity: 274/630 - (43%)
• Similarity: 399/630 - (63%)
• Gaps: 9/630 - (1%)

Human     1 MESGPKMLAPVCLVENNN-EQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHG 64
            |..|..|.|||||:||:. .:|.|.::|..||::|::|||||::|||||||||||||.|||:..|
Zfish     1 MAFGRHMSAPVCLIENDEFGKLCVKKEAKDILDEINEPVVVVSVVGLYRTGKSYLMNRLAGKQSG 65

Human    65 FPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYN 129
            |.||||::|:||||||||||||.|..||||||||||||||:|||.|:|:|||.|||||.|..|||
Zfish    66 FALGSTIESKTKGIWMWCVPHPDKKGHTLVLLDTEGLGDVDKGDEKHDTWIFCLAVLLSSALVYN 130

Human   130 SMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPI 194
            |:..|::.|||:|||||||||.|:.||....| .::|.||:..||.|:|.|||||||||::..||
Zfish   131 SLGVIDNMALEKLHYVTELTENIRVKSEGNQD-EDESEEFMRVFPSFVWAVRDFTLELKMDDKPI 194

Human   195 TEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDP 259
            |.|||||:||||.:|::|::...|.||.|:|.||..||||||.||.:.:| :..:|.::|.:||.
Zfish   195 TSDEYLESALKLKKGHSPQIAQYNLPRRCLREFFAPRKCFVFPRPASTQD-MKRMEDLTEGELDS 258

Human   260 KFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENS 324
            :|.:|.|.|||||:.....||::.|.|:||..||.||..|||||.||.||||||||::||:.:|.
Zfish   259 EFLQQANTFCSYIYDSTEPKTVKGGRTITGTALGNLAEVYVEAIRSGKVPCLENAVVSLAKIQNV 323

Human   325 AAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMN 389
            .||::|...|..:|....:||.|. :||..:|...|::||..|:..||.|.:|.:|::.|....|
Zfish   324 RAVEQALQIYMTEMLSMAQLPLDP-EELSSIHTLAEKKAIEEFINMSFNDNDQIYQQELMGKIHN 387

Human   390 KKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGV 454
            :..|...||.::|:..||..|.::...|..:||.||:..|||::.|.....::...|....:..:
Zfish   388 EYQDLCQQNHQASLMQCQEVLEDVFDPLEMNISNGSYLRPGGYREYRALLAQLTSSYRARTKSQI 452

Human   455 KAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQ 519
            .::||...||:.:..:...|||:|::|:..|:...|...|.|..::.|..|:::.:.|:|..:..
Zfish   453 MSEEVLCMFLKGKEDVGNMILQADESLSAAEQEKEVQMLKNEILQQRQRGLEEQNRLQEQAFKDM 517

Human   520 DKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDT 584
            :::.:|::.|:..:::.|:|.:.|:...:||...|.:...|.:||:::...|..||:..|..:..
Zfish   518 ERTHQEHVNQIVHQMEREQERIRRDNERVLEAKLKEREALLKQGFEEEASRMQKEINSLKTDMSK 582

Human   585 TKNDDTPWIARTLDNLADELTAILSAPA---KLIGHGVKGVSSLF 626
            .:......:.:.||.:....|..|  |.   |..|.|:..:|.||
Zfish   583 QEESKPSTMRKVLDGIGTAATLFL--PGFIPKAAGIGLSFLSRLF 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250|UniProtKB:P32455	1..310		182/309 (59%)
		GBP	18..281	CDD:460516	155/263 (59%)
		GBP_C	283..579	CDD:460721	96/295 (33%)
gbp2	XP_699217.3	None