DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP6 and atl

DIOPT Version :9

Sequence 1:	NP_940862.2	Gene:	GBP6 / 163351	HGNCID:	25395	Length:	633	Species:	Homo sapiens
Sequence 2:	NP_001287506.1	Gene:	atl / 42934	FlyBaseID:	FBgn0039213	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	416	Identity:	97/416 - (23%)
Similarity:	165/416 - (39%)	Gaps:	77/416 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    14 VENNNEQ--LLVNQQAI-QIL---EKISQPVVVVAIVGLYRTGKSYLMNH--------------- 57
            |.|.:|:  .::|:.|: ::|   |...:.|.||::.|.:|.|||:|::.
  Fly     8 VINASEEHTFVLNEDALSEVLMRDEVKDRFVCVVSVAGAFRKGKSFLLDFFLRYMYSKYVHHDAT 72

Human    58 --LAGQN---HGFPLGSTVQSETKGIWMW----CVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDS 113
              |.|::   .||......:.:|.||.||    ...:|:.....::||||:|..| .:...::.:
  Fly    73 DWLGGESDPLEGFSWRGGSERDTTGILMWSDIFLHDYPNGDKIAIILLDTQGAFD-SQSTVRDCA 136

Human   114 WIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLW 178
            .:|||:.:|.|..:||....|....|:.|...||...|..|.:..:|            |....:
  Fly   137 TVFALSTMLSSVQIYNLSQNIQEDDLQHLQLFTEYGRLALADTGKKP------------FQRLQF 189

Human   179 TVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRP---- 239
            .|||::...:.....:..|:.|:..|::....:|.:|:.   |..|...|.:..||:...|
  Fly   190 LVRDWSFPYEAEYGALGGDKILKRRLEVSDKQHPELQSL---RRHISSCFTEVACFLMPHPGLNV 251

Human   240 -TNDK------DLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAV 297
             ||.|      |:.... |.|.:.|.|......|:....|          .|..|....|.....
  Fly   252 ATNPKFDGRLQDITPEF-KSSLRSLVPMLLAPDNLVYKEI----------SGQRVRARDLIQYFQ 305

Human   298 TYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQ-----RVKLPTDTLQELLDMHA 357
            :|:.......:|..::.::..|:..:..||..|.:.|.|.|.:     |..|.|..||   ..|.
  Fly   306 SYMNIYKGNELPEPKSMLVATAEANHLTAVAAAKELYGQLMEEVCGGTRPYLSTAHLQ---TEHL 367

Human   358 ACEREAIAIFMEHSFKDENQEFQKKF 383
            ..:.:|:..|.... |...:||.:||
  Fly   368 RVKDKALFQFAAKR-KMGGEEFTEKF 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		76/336 (23%)
		GBP	18..281	CDD:280433	70/303 (23%)
		GBP_C	283..579	CDD:202427	25/106 (24%)
		GBP_C	289..579	CDD:293879	23/100 (23%)
		coiled coil	548..559	CDD:293879
		coiled coil	568..579	CDD:293879
atl	NP_001287506.1	GBP	14..289	CDD:280433	68/291 (23%)
atl	NP_001287506.1	MSC	<316..>471	CDD:286487	21/81 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142066
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750