DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP6 and atln-2

DIOPT Version :9

Sequence 1:	NP_940862.2	Gene:	GBP6 / 163351	HGNCID:	25395	Length:	633	Species:	Homo sapiens
Sequence 2:	NP_502809.2	Gene:	atln-2 / 189829	WormBaseID:	WBGene00012763	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	498	Identity:	105/498 - (21%)
Similarity:	185/498 - (37%)	Gaps:	141/498 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    10 PVCLVENNNEQ---LLVNQQAIQIL----EKISQPVVVVAIVGLYRTGKSYLMN---------HL 58
            ||.::..::.|   ..:|:.|:..:    ...::.:|::::.|.:|.|||:|:|         |.
Worm    29 PVQIIAPSSTQPGKFRLNESALNSVLGHSACANKKIVIISVAGAFRKGKSFLLNFFLEYLYSLHK 93

Human    59 AGQN-------------HGFPLGSTVQSETKGIWMWCVP----HPSKPNHTLVLLDTEGLGDVEK 106
            :.|:             |||...:.|:.:|.|||:|..|    ..:.....:||:||:|..|
Worm    94 SQQSDSSLEWLTDDCQLHGFHWRAGVKRDTVGIWLWGEPIMIESVTGEMFAVVLMDTQGTFD--- 155

Human   107 GDPKNDSW-----IFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDS 166
               .|.::     :|||:.::.|..:||.:..|...||:.|....|...:          .:|..
Worm   156 ---NNSTYQQCMTVFALSTIVSSVQIYNVVDNIQEDALQHLSLFVEYGRI----------AMEQP 207

Human   167 TEFVSFFPDFLWTVRDF----TLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRF 227
            ..|...|...::.||||    ..|...||    ..::|:|.|   |.|..:.:.....||.:|.:
Worm   208 HNFGKPFQQLVFCVRDFKNQEEYEFGENG----GTDFLDNVL---QTNPEQPEEIKQVRELLREY 265

Human   228 FPKRKCFVFDRPTNDKDLLANIEKVSEKQ--------LDPKFQEQ-TNIFCSYIFTHARTKTLRE 283
            |...:|::...|.         .||:|:|        |.|.|:|: ..:..:.:..|.....:..
Worm   266 FEDIQCYLLPHPG---------YKVAERQSFRGHVKDLRPLFREELKKMVPNLLGPHILKPKIVN 321

Human   284 GITVTGNRLGTLAVTYVEAINSGAVP-------------CLENAVITLAQRENSAAVQRAAD--- 332
            |.|||..::......|..:.:...:|             |:|      |..|......|..|
Worm   322 GKTVTCRKMIQYFKEYAASFDGETLPQPQSILNANAKLICIE------AAHEAKVNYSRGMDRST 380

Human   333 YYSQQMAQRVKLPTDTLQELLDMHA-----------ACER----EAIAIFMEHSFKDENQEFQKK 382
            |.::.|:::         :||:.|.           .|.|    |...:.:|...:|.|.|.:|
Worm   381 YGTRMMSEK---------KLLEAHIKHGITALNIFDKCPRIGAKEVRNLLLEKLQEDINAELEK- 435

Human   383 FMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGS 425
                       :...||...|..|.:.:......:...|..||
Worm   436 -----------YKRLNEAKRVTGCASAMLACGDSVFLGIGLGS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		79/363 (22%)
		GBP	18..281	CDD:280433	71/313 (23%)
		GBP_C	283..579	CDD:202427	32/174 (18%)
		GBP_C	289..579	CDD:293879	28/168 (17%)
		coiled coil	548..559	CDD:293879
		coiled coil	568..579	CDD:293879
atln-2	NP_502809.2	P-loop_NTPase	41..310	CDD:393306	69/300 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820