DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP6 and atln-1

DIOPT Version :9

Sequence 1:	NP_940862.2	Gene:	GBP6 / 163351	HGNCID:	25395	Length:	633	Species:	Homo sapiens
Sequence 2:	NP_001023492.1	Gene:	atln-1 / 177059	WormBaseID:	WBGene00021868	Length:	573	Species:	Caenorhabditis elegans

Alignment Length:	469	Identity:	109/469 - (23%)
Similarity:	185/469 - (39%)	Gaps:	94/469 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     5 PKMLAPVCLVENNNEQLLVNQQAIQILEKI-------SQPVVVVAIVGLYRTGKSYLMN----HL 58
            |:.:..|.:||:.:....:|   .::||||       .:.|.|:.:.|.||.|||:|:|    :|
Worm    30 PQAVRVVEVVEDTDHSFELN---TELLEKILLDPKVADKKVAVIGVAGAYRKGKSFLLNFFLRYL 91

Human    59 AGQN-----------------------HGFPLGSTVQSETKGIWMWCVPHPSKPNH----TLVLL 96
            ..::                       .||......:.:|.||.:|..|...|..:    .::|:
Worm    92 TWRSKADKVMGEVELDNSQWMSPNSPLSGFSWRGGSERDTNGILIWSEPFIMKDKNGEEIAVLLM 156

Human    97 DTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPD 161
            ||:|..| .:...|:.:.||||:.::.|..:||....|....|:.|...||...|....|:.:|
Worm   157 DTQGAFD-SQSTVKDCATIFALSTMISSVQIYNLSQNIQEDDLQHLQLFTEYGRLALEDSASKP- 219

Human   162 GVEDSTEFVSFFPDFLWTVRDFTL----ELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRE 222
                       |...|:.|||::.    |....|    ....|:..|::.:..:..:|..   |:
Worm   220 -----------FQSLLFLVRDWSFPYEAEFGFQG----GQRVLDRRLEVSEKQHAELQQL---RQ 266

Human   223 CIRRFFPKRKCFVFDRP-------TNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIF-THARTK 279
            .||..|...:||:...|       .|....|.:||.        :||:|..:....:. :||...
Worm   267 HIRSCFEDIRCFLMPHPGLKVATNPNFDGKLVDIEN--------EFQQQLGVMIPRLLDSHALVH 323

Human   280 TLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRV-- 342
            ....|..:|...|......|:.......:|..::.::..|:..|.|||..|...|.::|.:..
Worm   324 KEINGQKMTCRELLEYFKAYMHIFRGQDLPEPKSMLMATAEANNLAAVASARAVYQREMEEVCGG 388

Human   343 KLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQ 407
            ..|..:..|||:.|...:..||..| .::.|....:|..:|:|   ..:.|.    :||...|
Worm   389 DTPYMSTNELLEHHDRVKNIAIREF-RNARKMGGVDFSMQFLE---RLESDL----QESYENY-- 443

Human   408 AKLNELSKGLMESI 421
            .|:|. .|.|.:|:
Worm   444 LKVNN-GKNLFKSM 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		79/354 (22%)
		GBP	18..281	CDD:280433	71/312 (23%)
		GBP_C	283..579	CDD:202427	34/141 (24%)
		GBP_C	289..579	CDD:293879	32/135 (24%)
		coiled coil	548..559	CDD:293879
		coiled coil	568..579	CDD:293879
atln-1	NP_001023492.1	P-loop_NTPase	43..325	CDD:393306	71/312 (23%)
atln-1	NP_001023492.1	GBP_C	351..>447	CDD:308475	26/105 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920