Protein Alignment GBP6 and Gbp4

DIOPT Version :9

• Sequence 1: NP_940862.2
• Gene: GBP6 / 163351
• HGNCID: 25395
• Length: 633
• Species: Homo sapiens
• Sequence 2: NP_001346008.1
• Gene: Gbp4 / 17472
• MGIID: 97072
• Length: 644
• Species: Mus musculus
• Alignment Length: 646
• Identity: 403/646 - (62%)
• Similarity: 486/646 - (75%)
• Gaps: 37/646 - (5%)

Human     5 PKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNH------ 63
            |:| ||:|||||:||||.|||:||:||:|||||||||||||...||||||||.||||||
Mouse    17 PQM-APICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLP 80

Human    64 ---GFPLG--STVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLC 123
               .||.|  ..|..:.....:...||.::   .||||||||||||||||||||.|||||:|||.
Mouse    81 TSQRFPSGLHRAVSDQGHLDVVHAPPHQAR---ALVLLDTEGLGDVEKGDPKNDLWIFALSVLLS 142

Human   124 STFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELK 188
            ||||||||:||||||||||||||||||||:|||||.|.|:::|||||||||||:||||||.||||
Mouse   143 STFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELK 207

Human   189 LNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVS 253
            |||..||.|||||||||||.|||||:|.||..|||||||||.||||||:.||:|.:|:..:|.:|
Mouse   208 LNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETIS 272

Human   254 EKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITL 318
            |.||||.|:|....|.|||||:|:.|||||||.||||.||||..|||:||||||||||::||.||
Mouse   273 EDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTL 337

Human   319 AQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKF 383
            ||||||.|||:||.:||:|||||:.|||||:|||||:|||||:||:|:|||||||||||:|.||.
Mouse   338 AQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKL 402

Human   384 METTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQ 448
            :|....|.|.|||:|||:|.:|||.:|:.|||.||::||  :|||||||:|||:.:|:||.||||
Mouse   403 VELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNIS--TFSVPGGHRLYMDMREKIEHDYWQ 465

Human   449 VPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQ 513
            ||||||||.||||.||:||.:||.||||:|.|||..:||:|....|||||||||:||:||.:|.|
Mouse   466 VPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQ 530

Human   514 QQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQF 578
            :.||||:|..|||:.||:.||:.|||.|:::..||||...|.|..:..||:|.:.||:..||.|.
Mouse   531 EYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQL 595

Human   579 KRMIDTTKNDDTPWIARTLDNLADELT----AILSAPAKLIGHGVKGVSS----LFKKHKL 631
            ...|...|.:.        |:|.:.:.    :.:|.|::    ..|.:||    |.||.:|
Mouse   596 GHNIKEMKQNG--------DSLVESILRSWFSFISPPSE----SEKAISSVLSLLRKKDRL 644

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		221/315 (70%)
		GBP	18..281	CDD:280433	188/273 (69%)
		GBP_C	283..579	CDD:202427	190/295 (64%)
		GBP_C	289..579	CDD:293879	185/289 (64%)
		coiled coil	548..559	CDD:293879	5/10 (50%)
		coiled coil	568..579	CDD:293879	5/10 (50%)
Gbp4	NP_001346008.1	P-loop_NTPase	29..300	CDD:328724	188/273 (69%)
		GBP_C	302..595	CDD:308475	189/294 (64%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83959775
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2037
HGNC	1	1.500	-	-
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H128731
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55037
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100467
Panther	1	1.100	-	-	O	PTHR10751
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	12.220