DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GBP6 and gbp6

DIOPT Version :9

Sequence 1:	NP_940862.2	Gene:	GBP6 / 163351	HGNCID:	25395	Length:	633	Species:	Homo sapiens
Sequence 2:	NP_001120628.1	Gene:	gbp6 / 100145795	XenbaseID:	XB-GENE-6050518	Length:	628	Species:	Xenopus tropicalis

Alignment Length:	640	Identity:	308/640 - (48%)
Similarity:	414/640 - (64%)	Gaps:	26/640 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MESGPKMLAPVCLVENNNE----QLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQ 61
            |..|..|..||||:||.|.    :|::||:|:||||.|::|||.|||||.||||||||||.|||.
Frog     1 MSRGVVMSHPVCLIENQNTPEGYKLVINQKAVQILEDITEPVVPVAIVGKYRTGKSYLMNKLAGS 65

Human    62 NHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTF 126
            |.||.||||:||:||||||||||||.||.||||||||||||||||||.|||||:|:|||||.||.
Frog    66 NDGFALGSTIQSKTKGIWMWCVPHPHKPGHTLVLLDTEGLGDVEKGDRKNDSWVFSLAVLLSSTL 130

Human   127 VYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNG 191
            ||||:.||:.::||:|||||||||.||.|:....|. ::|.||...||.|:|.||||||:|:..|
Frog   131 VYNSVGTIDQESLEKLHYVTELTERIKLKAKTSNDD-DESAEFKRTFPSFIWCVRDFTLKLEQEG 194

Human   192 HPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQ 256
            ..|||||||:.||.|..|.:...:..|||||||..||...|||||:||.:.:| |..:|::||.|
Frog   195 KQITEDEYLQMALNLKPGFSKAAREYNFPRECITHFFHSHKCFVFERPASTED-LQRLEELSESQ 258

Human   257 LDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQR 321
            |:|:|.:|.:.||.::|.:::||||..|..|||..||||||||||:|.||:|||:||||:.|||.
Frog   259 LEPRFVKQAHRFCDFVFNNSQTKTLAGGHCVTGRMLGTLAVTYVESIRSGSVPCMENAVLALAQI 323

Human   322 ENSAAVQRAADYYSQQMAQ-RVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFME 385
            ||:||:|:|...|..:|.| ....||:|..|.|.....||::|:.:||:.||||:.:|:|.|.|.
Frog   324 ENTAAIQKALSVYEAEMKQAEGTFPTETQDEFLSKQTQCEKKAVKVFMDRSFKDDKREYQGKLMG 388

Human   386 TTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVP 450
            ....|..:|..:|||:|:..||..|..||..|.:.|....||.|||||.|::.|::|...|...|
Frog   389 DLQQKHQEFAKRNEEASIHKCQDLLQVLSANLEKGIKNVVFSKPGGHKQYLKEKQKIMDTYNNSP 453

Human   451 RKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQ 515
            .||:||..|.|:|:|.:..||.::||:|::||.::|.:..::.|||||||       ||||:::.
Frog   454 GKGIKAALVLQQFIEGKKNIEMTVLQADESLTKQQKEMEEEKMKKEAAEK-------KLQEEKEN 511

Human   516 MEAQDKSRKENIAQ-------LKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNA 573
            ....:::|||...:       |||||:.||..||:|...|::...|.:.....||...|...:..
Frog   512 ARQLERTRKEQTQRLEQQAIMLKEKLEEERHMLLKENEWMIKEKMKEREKLAQEGLHNKAGMLGE 576

Human   574 EISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKK 628
            :::..:...:...:.:  ||...:..|.:  .|.|:.|. ..|.....|||..::
Frog   577 QVNALQHQNNEISSPN--WILEGIGTLVE--VASLALPG-AFGKAATVVSSFIRR 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GBP6	NP_940862.2	GTPase domain (Globular). /evidence=ECO:0000250	1..310		192/312 (62%)
		GBP	18..281	CDD:280433	163/266 (61%)
		GBP_C	283..579	CDD:202427	124/303 (41%)
		GBP_C	289..579	CDD:293879	121/297 (41%)
		coiled coil	548..559	CDD:293879	2/10 (20%)
		coiled coil	568..579	CDD:293879	0/10 (0%)
gbp6	NP_001120628.1	P-loop_NTPase	25..283	CDD:422963	162/259 (63%)
gbp6	NP_001120628.1	GBP_C	291..582	CDD:293879	121/297 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	345	1.000	Domainoid score	I7575
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H128731
Inparanoid	1	1.050	596	1.000	Inparanoid score	I6507
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027269at2759
OrthoFinder	1	1.000	-	-		FOG0000238
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10751
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160