DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and dennd2c

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	XP_012821186.1	Gene:	dennd2c / 780108	XenbaseID:	XB-GENE-5955506	Length:	943	Species:	Xenopus tropicalis

Alignment Length:	952	Identity:	599/952 - (62%)
Similarity:	707/952 - (74%)	Gaps:	44/952 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     2 DVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLK-KNPIAE 65
            :.||||::.||||||||||||:|||:||||.:...              :|...:.:| :.|..:
Frog    11 ECGFSRSSQQTLSRSHCKNIKEKISKWEGRTSNSG--------------SCGDLLNVKPERPPRD 61

Human    66 RK-----------SKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCS 119
            |.           ::..|:.......||..|..:. .:...||.:...||::.::.|.|||....
Frog    62 RNAFTHSTAGRLDNRKTDLLRTRQFDLDFREGGRG-SRFNKENYRINKDDSNVYEEELESNSSYF 125

Human   120 RVKEIESCKEDVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALE------HCDSSEKELNF 178
            ..:|.|:   :.|||:..|||||||||..::||...:..|.|..:.||      ..:|::.||:.
Frog   126 SGRENEN---EYLDPDIELPPGNFYTSPGMFKKGSVISEDNLKEMVLEFKRKRGRSNSADGELDL 187

Human   179 RVLDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSC 243
            :.|.|.....|||||||.:.||.:..|||||:|||||||||.:|......|:.|..::...:.|.
Frog   188 KCLTSQNFAIKSLENIYYDTEGLKDIPSINPVPKPRRTFRYSTEHHPEERKDYNHRRRKSVDESD 252

Human   244 AQSSLASSQEPEPKKYGG-KIRGRSKRKSFEFEDIQHFR----NRNSQTIREELGRNSGSALYYT 303
            .:||..|...|||||.|. |:|.|||||||||||:|.||    ..|...|.||....|.||||:|
Frog   253 TESSDPSVPPPEPKKTGNRKLRPRSKRKSFEFEDVQTFRRFIHQANHPEISEEPREPSRSALYHT 317

Human   304 QSEDNIYEDIIYPTKENPYEDIPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFLHRKTMEVK 368
            .|||||||||:|||||||||||.:.|||:||.||.|||||.:...||||:|.||.||.|:|:|:|
Frog   318 VSEDNIYEDIMYPTKENPYEDIKISPLPVWRVPSTWKLPPPRCTIKAPKIPSKPNFLKRQTLELK 382

Human   369 NSQAYLRSKLTKDTTLPVTLTEWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYT 433
            :::.||..|..||:||||||.|||:||....:..|||..||||:||.|||::|||||:||:.::|
Frog   383 STKLYLHKKAAKDSTLPVTLMEWKVFRGVAESTKKRKAFPRLVMKIQDIFDAKRGKKRVKVQTFT 447

Human   434 GKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVS 498
            |::..|:|||.|..|||.|...|...|||.|:..|.|||||||||||||||||||||||||||||
Frog   448 GQDSSPSKGEASETESDTEDRQKKHCKRLVQVPNSLKRNPHYQTLERDLIELQEQQLFELFVVVS 512

Human   499 LQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVL 563
            |.|..||..|:|.||||:|.|::...|||:|||:|||:||:|||||||||..|||||||||||||
Frog   513 LHKSSSGDGYVPAVIQQYPPKNETPVKQSRDMEDRLKLIPQFCFPDSKDWTTTSELKSETFSFVL 577

Human   564 TGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPA--LVYPFMR 626
            |||||||||||||||||.|:|||||||||||||||||||||||||||||||:||..  ||..|||
Frog   578 TGEDGSRWFGYCKKLLPQGRGKRLPEVYCMVSRLGCFNLFSKILDEVEKRRKMSEKKDLVSMFMR 642

Human   627 SVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLE 691
            ||||||||||||||||||.|||:||..||||||:|||||||||.|||:||||..||:|.||||||
Frog   643 SVMEAPFPAPGRTITVKSSLPGSGDGVIELCRPMDSRLEHVDFDCLFRCLSVTLLIKVFASLLLE 707

Human   692 RRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQD 756
            |||||||::|||||||.|||:|.||||||||||||||||||||||||||||||||||||||.|.|
Frog   708 RRVIFVADNLSTLSKCAHAVLAILYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPLLSD 772

Human   757 LPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEA 821
            ||||||||||||.:||||.:||||:|||.||||||.||||:|:.|:.||| .:::||||||||||
Frog   773 LPIEEVLIVDLCGNKFLQALSDEDDILPHKLQAALAQILEQRDHIMFQEQ-LTEEVTLNSLVSEA 836

Human   822 FVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKS 886
            ||.||||:||||||:|.|.|:||||||||||||.|||||.|.|||:||||||||||.||||||||
Frog   837 FVWFFVEIVGHYSLHMYVNEKGERVFQREPFRKCHTSRSTRQFLDVFMETQMFAGFTQDRELRKS 901

Human   887 GVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFLQKK 928
            |||||||:||.:||:|:||:||||:|:.||.|||||||||||
Frog   902 GVKGLFEVRACEYLKTLPETEPSGVNKFLRGLGSKMKFLQKK 943

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105		7/48 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266		11/21 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456		12/27 (44%)
		uDENN	487..576	CDD:214824	68/88 (77%)
		DENN	586..770	CDD:280329	160/185 (86%)
		dDENN	815..881	CDD:129037	54/65 (83%)
dennd2c	XP_012821186.1	uDENN	501..590	CDD:214824	68/88 (77%)
		DENN	600..786	CDD:366936	160/185 (86%)
		dDENN	830..896	CDD:129037	54/65 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	453	1.000	Domainoid score	I4656
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19542
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I2492
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39929
OrthoDB	1	1.010	-	-		D138384at2759
OrthoFinder	1	1.000	-	-		FOG0001293
OrthoInspector	1	1.000	-	-		oto150266
Panther	1	1.100	-	-	LDO	PTHR15288
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	1	1.000	-	-		X8674
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110