DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and dennd2c

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	XP_001919086.4	Gene:	dennd2c / 570947	ZFINID:	ZDB-GENE-081105-71	Length:	920	Species:	Danio rerio

Alignment Length:	991	Identity:	480/991 - (48%)
Similarity:	592/991 - (59%)	Gaps:	176/991 - (17%)

- Green bases have known domain annotations that are detailed below.

Human    20 NIKQKISQWEGRANGISNPEKWCPKDFGVRYNCHQEIRLKK----NPIAERK------SKNLD-- 72
            |||||||||||...                   .::||..|    ..:|.|:      ...||
Zfish    24 NIKQKISQWEGLTQ-------------------QEDIRSGKVQTQRTLASRRLSEDLLGNGLDSS 69

Human    73 --------VTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVC---SRVKEIES 126
                    |...:::|||..||.|:......|.|      .:|.:|....| .|   |.|.:::.
Zfish    70 DGGRNKATVFKAKSLGLDFRENLKTFKPVTPEVK------PNFPRNRDHLN-KCVTPSTVSQVQV 127

Human   127 CKEDV---------------------LD-PETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHC 169
            .|.:|                     :| ||.||||||||||:..||::||
Zfish   128 AKPNVKINNINSSHFSNVEITSLPQCVDYPEPSLPPGNFYTSRGFWKRLEA-------------- 178

Human   170 DSSEKELNFRVLDSSYGITKSLENIYSEPEGQECGPSINPLPKPRRTFRYLSESGVT-----PYK 229
            |.|..|   |..|||. :||          |.:.||| :|.|||:|||:|...|..|     |
Zfish   179 DESFWE---REKDSSL-MTK----------GLDFGPS-SPPPKPQRTFQYKGASSPTNQWIQP-- 226

Human   230 ERNCDKKYCENNSCAQSSLASSQE-----------PEP---KKYGGKIRGRSKRKSFEFEDIQHF 280
                     ||.:.|.|.|...|:           |.|   ....|..|.|..||||||||:...
Zfish   227 ---------ENQTPAVSKLNQVQKHDIILKPPSCPPPPCPVNTVNGFSRHRKNRKSFEFEDVVRL 282

Human   281 RNRNSQTI-REELGRNSGSALYYTQSEDNIYEDIIYP-TKENPYEDIPVQP--LPMWR----SPS 337
               ::||. |.:..|.||  ||:..|||:||||||.. .||||||||.:.|  ||:.|    :..
Zfish   283 ---SAQTASRGKESRRSG--LYHALSEDSIYEDIISDMPKENPYEDITLSPMCLPIRRQRNYTVG 342

Human   338 AWKLPPAKSAFKAPKLPPKPQFLHRKTMEVKNSQAYLRSKLTKD----TTLPVTLTEWKLFRAGE 398
            ..:.|..|.:.|...|.|....||               |:.:|    ||.|...|.....|:..
Zfish   343 QRERPQLKLSPKPFTLLPNGDRLH---------------KVGRDHRQLTTSPTCSTISSSPRSSA 392

Human   399 V---ANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHK 460
            |   |..|....|.||.:|.:|||||||:|:|...:        |:.|.||.|||.|...|:|..
Zfish   393 VKPAALYKTSRQPLLVNRIQEIFESKRGRKRVWATA--------TREELSGTESDPEENSKDRSH 449

Human   461 RLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYK 525
            |...:|.:.||.|.|:|||||||:||:||||:.||||||:|...|.:|||::.||||.|.:...:
Zfish   450 RTVYVQSTLKRRPGYRTLERDLIQLQQQQLFQQFVVVSLRKGSPGNTYIPEITQQFPTKFEKSSR 514

Human   526 QSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEV 590
            .|::.|:||:.||||||||..||.|:|:..|||||||||||||||.||||:|:||.|||||||||
Zfish   515 LSREAEDRLRAIPKFCFPDCHDWRPSSDHTSETFSFVLTGEDGSRLFGYCRKILPSGKGKRLPEV 579

Human   591 YCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIE 655
            :|:||||||||||||||:|||:|||:|||||.|||.||||||||||||||||||:|||:|:|.:.
Zfish   580 HCIVSRLGCFNLFSKILEEVERRREISPALVSPFMHSVMEAPFPAPGRTITVKSFLPGSGNEVLT 644

Human   656 LCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTW 720
            ||||:|||||||||:.|.:||||..|::|.|||:|||||||:|:.||.||:|.|:.:|.||||||
Zfish   645 LCRPVDSRLEHVDFESLLQCLSVSRLLQVFASLMLERRVIFIADKLSVLSRCAHSALALLYPFTW 709

Human   721 QHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPP 785
            |||::|||||.|:||.||||||::|.||.|||::.|:|||||||||||.|||:.::.|||.|||.
Zfish   710 QHTFVPVLPAGMLDICCSPTPFVMGALSPSLPEVLDMPIEEVLIVDLCTDKFVVQLGDEDCILPS 774

Human   786 KLQAALMQILEERNEILTQEQ--NFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVT-ERGERVF 847
            ||||||.:|||.|.|||.|.:  .......|::|||||||.||||:||||||.|..: ..|.|..
Zfish   775 KLQAALQEILENREEILEQNRRDRRGDKSDLSTLVSEAFVWFFVEIVGHYSLYMNDSGPGGTREL 839

Human   848 QREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPSGMN 912
            ||:.|||||.||.||..|.|||:|||||||||||||||.|||||||:||.:||::.||.|.||:|
Zfish   840 QRDAFRKSHPSRGVRQLLQLFMDTQMFAGFIQDRELRKGGVKGLFELRAAEYLDSYPEPETSGVN 904

Human   913 RILRSLGSKMKFLQKK 928
            |.|:.||:||||||||
Zfish   905 RFLKGLGNKMKFLQKK 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105		11/53 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266		7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456		8/27 (30%)
		uDENN	487..576	CDD:214824	54/88 (61%)
		DENN	586..770	CDD:280329	136/183 (74%)
		dDENN	815..881	CDD:129037	44/66 (67%)
dennd2c	XP_001919086.4	uDENN	<494..565	CDD:214824	43/70 (61%)
		DENN	575..759	CDD:280329	136/183 (74%)
		dDENN	806..873	CDD:129037	44/66 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194331032
Domainoid	1	1.000	289	1.000	Domainoid score	I7878
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19542
Inparanoid	1	1.050	753	1.000	Inparanoid score	I3834
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39929
OrthoDB	1	1.010	-	-		D138384at2759
OrthoFinder	1	1.000	-	-		FOG0001293
OrthoInspector	1	1.000	-	-		oto44435
orthoMCL	1	0.900	-	-		OOG6_105255
Panther	1	1.100	-	-	LDO	PTHR15288
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8674
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	17	17.310