DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and pns

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_647620.1	Gene:	pns / 38178	FlyBaseID:	FBgn0035229	Length:	1449	Species:	Drosophila melanogaster

Alignment Length:	763	Identity:	143/763 - (18%)
Similarity:	235/763 - (30%)	Gaps:	309/763 - (40%)

- Green bases have known domain annotations that are detailed below.

Human   426 KVKLHSYTGKELPPTKGETSGNESDAEYLPKNRHKRLAQLQPS----SKRNPHYQTLERDLIELQ 486
            |:.|.|.:|      .|..:|:..:.:..|.:   .|.|...|    |:.......|:|| .:.|
  Fly    14 KLMLSSGSG------NGSGNGSGPNIQVAPSS---TLVQSPTSPGEQSQSQSELNQLKRD-ADPQ 68

Human   487 EQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWMPT 551
            ..:..:.||:..|. ..:|:.  |   .:|.|.:.|    ...::...|..|...:|::..|.|.
  Fly    69 FSRFADYFVICGLD-LDTGLE--P---DRFAGDNLH----CSPLDRAYKSKPLAHYPENVPWNPF 123

Human   552 SE--------------------LKSETFSFVLTGEDGSRWFGY-------------C-------- 575
            ..                    ::....||..|.|||.|.:|:             |
  Fly   124 DAHGICMLSLPQGLRFRTQKHCIEPRFHSFATTREDGKRCYGFSLVFYEEIRNRNICGAIHTLQS 188

Human   576 ------------------------KKLLP-----VGKGKRLPEVY-----------------CMV 594
                                    .:.||     .|:..:..:.|                 |..
  Fly   189 MFITELSNGQQTHSLSRVKQDGPVSRSLPRHFKVAGQAPQSAQSYYDINKDKLYVAKSITLICQA 253

Human   595 SRLGCFNLFSKILDEVEKRREMS----PALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDE--- 652
            .......:|.|.|.....|:..:    .:.||..:..||   .|.||::|.|  |||.....
  Fly   254 PYAFAAQMFLKNLYRCLPRQPGAGISLESYVYNILYEVM---LPQPGKSIRV--YLPPTEPHLPP 313

Human   653 -SIELCRP-LDSRLEHVDF--KCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVA 713
             ::.|.|| |.:.|..:||  :.|||.|.|..:|::...:|||.:|:..:.....|...|..:.:
  Fly   314 IALILQRPLLATELPLLDFPLRLLFKYLGVECVIQLLTCVLLENQVLLRSTDYQRLMIVGECITS 378

Human   714 TLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGI-LSC----------------------SLPQLQ 755
            .|:||.|.|.|.|:|||::...:.:|.||::|: ..|                      .||  :
  Fly   379 LLFPFVWPHVYAPILPAALHHFLDAPVPFVMGLHAECEAAHKIGSEATLCFVDIDKKHIQLP--E 441

Human   756 DLP-----IEEVLIVDLCADKFLQEVSDEDE---------------------------------- 781
            :||     ::.:..:....|||..| .|.|:
  Fly   442 ELPVFPHKVDFMAEIGSVLDKFEIE-RDRDQEPSFRNGYVGRGAGGGVSGSGSSGSGGVDAMISS 505

Human   782 -ILPPKLQAA-------------------------------------------LMQILEERNEI- 801
             .||..||||                                           :...|..:..|
  Fly   506 CTLPTGLQAARRSKERFQQMQETVYTLSGSPGGGVVDYQPLIAHPSRIDHVPRIADFLRRKGGIR 570

Human   802 ------------------------------------------LTQEQNFSQDVTLNSLVSEAFVR 824
                                                      |:....:.||:.:|:.|.|.|:.
  Fly   571 GAGSPVGSPTVSLSSSPVGIYHDVDAVDATMPVSTRRAEKQKLSPVDQYYQDLRINNSVREIFLN 635

Human   825 FFVELVGHYSLNMTVTE--RGERVFQREPF----RKSHTSRSVRH---FLDLFMETQMFAGFIQD 880
            .||.:...|...:....  |.|.:..||..    :.|..|....|   ||..|:|:||||..|.:
  Fly   636 RFVHMFHAYEYFVIYPNQARDEWISNRETLQNFDKSSFLSDQPEHHRAFLSRFLESQMFATLIDN 700

Human   881 RELRKSGVKGLFEIRAIQYLETIPESEPSGMNRILRSLGSKMKFLQKK 928
            :.|                  .:.||:|   :..|:....::|.|:::
  Fly   701 KIL------------------AMWESQP---DEQLQLFDQRVKLLRRR 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456		5/27 (19%)
		uDENN	487..576	CDD:214824	22/153 (14%)
		DENN	586..770	CDD:280329	56/239 (23%)
		dDENN	815..881	CDD:129037	23/74 (31%)
pns	NP_647620.1	uDENN	70..171	CDD:214824	21/110 (19%)
		DENN	243..435	CDD:214823	51/196 (26%)
		dDENN	626..701	CDD:129037	23/74 (31%)
		RUN	<989..1083	CDD:295434
		PLAT_RAB6IP1	1095..1203	CDD:238855
		RUN	1376..1436	CDD:214736
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940