DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DENND2C and CG18659

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_665880.2	Gene:	CG18659 / 35929	FlyBaseID:	FBgn0027561	Length:	908	Species:	Drosophila melanogaster

Alignment Length:	452	Identity:	126/452 - (27%)
Similarity:	204/452 - (45%)	Gaps:	60/452 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   488 QQLFELFVVVS----LQKKPSGISYIPQV-----IQQFPGKDDHGYKQSKDMEERLKVIPKFCFP 543
            ::|||.:..|:    |::..|..|..|.|     ::.||    .|::.    :|.|..||.|.||
  Fly    10 KKLFEFWCEVTPTPGLERGTSSRSGGPAVPAGVIVESFP----EGFRD----QEVLTGIPSFAFP 66

Human   544 DSKDWMPTSELKSETFSFVLTGEDGSRW-FGYCKKLLPVGKGKRLPEVYCMVSRLGCFNLFSKIL 607
                 ..|:....:|:|||.|..| |:| ||:|:      :..|......:::.|...:.|.|:|
  Fly    67 -----CDTTSTSVQTYSFVHTTGD-SKWRFGFCR------QDPRTNTAMVLITYLPWHDTFLKLL 119

Human   608 DEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRL----EHVD 668
            ..:.:.|...|.....|:........|..|.::  |.|. .||.......|||..:|    |:.:
  Fly   120 PVLAELRRTDPNGFRTFLSEAYNQGIPDCGGSL--KVYY-SAGQSHFTFERPLQFQLPSMPENHN 181

Human   669 FKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMI 733
            ....:..:....:|.|.|::|.|||:||.:..|..||.|..|..|.|||..|||.:|||||....
  Fly   182 LNLYYNFVEPKEMIAVFAAMLAERRIIFTSRHLDRLSSCIQAANAFLYPMVWQHIFIPVLPWEFK 246

Human   734 DIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEER 798
            |.:.:|.|:|||:....|..:....:.||:|:: |..|..:...|:...||.::.:.|.:.|
  Fly   247 DYLGAPMPYLIGVPEPVLETVTSDELGEVVILN-CDTKIFESPFDDVHNLPTEIVSQLKKHL--- 307

Human   799 NEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPFRKSHTSRSVRH 863
                    |.:.| .:...:|:.|:...|:|:|.|. :........:.|..:.|.:|..:. :|.
  Fly   308 --------NHTHD-HIGDRISKIFLNALVQLIGGYR-DAVEYHENSKTFNSQKFIESRPAH-LRP 361

Human   864 FLDLFMETQMFAGFIQDR-ELRKSGV--KGLFEIRAIQYLETIPESEPSGMN-RILRSLGSK 921
            ||...|:.|:||.||.|| .:..||:  ...||:..::|    .|.:..|.| .|:::|..|
  Fly   362 FLAKMMDLQIFAQFIDDRLTMLNSGLGFSDEFELETVRY----AEKKKRGRNYAIMKNLKDK 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456
		uDENN	487..576	CDD:214824	30/97 (31%)
		DENN	586..770	CDD:280329	56/187 (30%)
		dDENN	815..881	CDD:129037	18/65 (28%)
CG18659	NP_665880.2	uDENN	10..95	CDD:214824	31/104 (30%)
		DENN	98..282	CDD:280329	56/187 (30%)
		dDENN	315..379	CDD:129037	18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3569
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810