DRSC/TRiP Functional Genomics Resources

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Protein Alignment DENND2C and Crag

DIOPT Version :9

Sequence 1:NP_001243333.1 Gene:DENND2C / 163259 HGNCID:24748 Length:928 Species:Homo sapiens
Sequence 2:NP_001162710.2 Gene:Crag / 31800 FlyBaseID:FBgn0025864 Length:1671 Species:Drosophila melanogaster


Alignment Length:667 Identity:153/667 - (22%)
Similarity:257/667 - (38%) Gaps:165/667 - (24%)


- Green bases have known domain annotations that are detailed below.


Human   348 FKAPKLPPKPQFLHRKTMEVKNSQAYLRSKLTKDTTLPVTLTEWKLFRAGE--------VANTK- 403
            |....:|..||.|...:.   |....||:..|.:   |:|.........||        :::|. 
  Fly    10 FVVAGMPENPQLLQENSF---NDSGRLRAATTIE---PITDIGVYFPLLGEEVPEGYEILSHTPT 68

Human   404 --RKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKG---ETSGNE---SDAEYLPKNRHK 460
              :.||....::..|.:          ::...||:.||...   ...|:|   ||||.:.:....
  Fly    69 GLQANLNHGSVRTTDCY----------IYFRRGKDRPPLVDIGVLYDGHERIMSDAEIVAETPGG 123

Human   461 RLAQLQPSS--------------------------------KRNPH-----YQTLER-----DLI 483
            |:|.:..||                                :|.||     |:||.:     |:.
  Fly   124 RVANVNNSSAKTFLTYRRARADMPCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDVY 188

Human   484 ELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFP--DSK 546
            ...::.::          :|..|||.|:::.::|..|...:..:     ....:|.||.|  .|.
  Fly   189 LCYKKSMY----------RPKHISYKPEILLRYPTFDHTDFPLN-----LCPSVPLFCLPMGASL 238

Human   547 DWMP----TSELK--SETFS-FVLTGEDGS-RWFGYC----------------KKLL------PV 581
            :..|    |.:.|  |..|| ||||..||: :.:|..                |:||      ..
  Fly   239 EAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGWDEEFGA 303

Human   582 GKGKRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVM----EAPFPAPGRTITV 642
            .....:.:..|::|.....:.|.|.|..:.:.......:..|..|.:.    |.|||||    ::
  Fly   304 QHSLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIPVERYITQLLDEVPFPAP----SI 364

Human   643 KSYLPGAGDESIELCRPLDSRLEH--VDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLS 705
            ...|....::.|.|.:|.||.|..  ..|..|.:.|...:.:.|....|.|::::..:...:||:
  Fly   365 HLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLT 429

Human   706 KCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDL--PIEEVLIVDLC 768
            ....|:|:.|:||.||..|||:.|..:.:::.:|.|:|||:.|    :..||  |..:|..:||.
  Fly   430 AVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDS----RFFDLYEPPTDVTCIDLD 490

Human   769 ADKFLQEVSDEDEILPPKL---QAA--LMQILEE-----------RNEILTQEQNFSQDVTLNSL 817
            .:..  .:.:....|.|||   :||  |.|.|.|           .|.:....:...:::.|...
  Fly   491 TNNI--SLCESQRHLSPKLLPKRAARLLRQTLTELENAKPISYDSTNSLDRDIRKRKRELVLEQR 553

Human   818 VSEAFVRFFVELVGHYSLNMTVTERGERV--------FQREPFRKSHTSRSVRHFLDLFMETQMF 874
            :.|||:.|...::..|...:....:...|        ||.:.|.:|. .:|.:.|.:|.|:||||
  Fly   554 IQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSR-DKSHQKFFELMMKTQMF 617

Human   875 AGFIQDRELRKSGVKGL 891
            ..||::|.....|..||
  Fly   618 IRFIEERSFVSDGDHGL 634

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DENND2CNP_001243333.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..105
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..266
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..456 10/33 (30%)
uDENN 487..576 CDD:214824 25/114 (22%)
DENN 586..770 CDD:280329 51/191 (27%)
dDENN 815..881 CDD:129037 20/73 (27%)
CragNP_001162710.2 uDENN 189..279 CDD:214824 25/104 (24%)
DENN 308..492 CDD:307995 51/191 (27%)
dDENN 551..624 CDD:129037 20/73 (27%)
PPR repeat 808..837 CDD:276811
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3728
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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