DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and Dennd2c

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_001178498.1	Gene:	Dennd2c / 295333	RGDID:	1308197	Length:	923	Species:	Rattus norvegicus

Alignment Length:	929	Identity:	768/929 - (82%)
Similarity:	828/929 - (89%)	Gaps:	13/929 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MDVGFSRTTVQTLSRSHCKNIKQKISQWEGRANGISNPEKWCPKDFGVRY-NCHQEIRLKKNPIA 64
            |||||:|:.|||||||||||||||||||||||||::.|.|:.|||||||| |||||....|:|..
  Rat     7 MDVGFTRSAVQTLSRSHCKNIKQKISQWEGRANGVTQPAKFHPKDFGVRYNNCHQERPPHKHPTG 71

Human    65 ERKSKNLDVTSRENVGLDINENTKSHDQSENENKKHEYDDTHFFKNESESNWVCSRVKEIESCKE 129
            |.:          |.||..|.:.:||||||.|::..|..|.|..:.|..|:.:|:|||:||||:.
  Rat    72 EER----------NGGLPRNTDARSHDQSEGESESRELKDPHPLEGEPNSSRMCARVKQIESCQA 126

Human   130 DVLDPETSLPPGNFYTSQILWKKIEALPPDKLLNLALEHCDSSEKELNFRVLDSSYGITKSLENI 194
            ..:|||.||||||||||||.||.||.|.|:|:..:||..||.:|:|....||||||.:.||||||
  Rat   127 VAVDPEASLPPGNFYTSQIPWKSIEGLTPNKVFTVALSPCDFTEEEPELSVLDSSYRVAKSLENI 191

Human   195 YSEPEGQECGPSINPLPKPRRTFRYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKY 259
            |.|||||||||||||||||||||||||||...||||||||:|.||:..||.|||||.|:||||:|
  Rat   192 YCEPEGQECGPSINPLPKPRRTFRYLSESDGMPYKERNCDQKNCESVCCADSSLASFQDPEPKRY 256

Human   260 GGKIRGRSKRKSFEFEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYEDIIYPTKENPYED 324
            |||||||||||||||||||||  |||:.|.|||.||:||||||||||||||||||||.|||||||
  Rat   257 GGKIRGRSKRKSFEFEDIQHF--RNSRKIHEELERNAGSALYYTQSEDNIYEDIIYPAKENPYED 319

Human   325 IPVQPLPMWRSPSAWKLPPAKSAFKAPKLPPKPQFLHRKTMEVKNSQAYLRSKLTKDTTLPVTLT 389
            ||||..|:|||||||:||||||||:.||||||||||.|||||:||:|||||||||||||||||||
  Rat   320 IPVQSFPIWRSPSAWRLPPAKSAFRTPKLPPKPQFLQRKTMELKNTQAYLRSKLTKDTTLPVTLT 384

Human   390 EWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKELPPTKGETSGNESDAEYL 454
            ||||||||||||.|::|||||||||:|.||||||||:|||..|||||.|.:||||||||||||||
  Rat   385 EWKLFRAGEVANRKKRNLPRLVLKINDTFESKRGKKRVKLQPYTGKEAPSSKGETSGNESDAEYL 449

Human   455 PKNRHKRLAQLQPSSKRNPHYQTLERDLIELQEQQLFELFVVVSLQKKPSGISYIPQVIQQFPGK 519
            ||||||||||||.||||:||||||||||||||||||||||||||||||.||:.|:|:||||||.|
  Rat   450 PKNRHKRLAQLQQSSKRSPHYQTLERDLIELQEQQLFELFVVVSLQKKASGMEYMPRVIQQFPSK 514

Human   520 DDHGYKQSKDMEERLKVIPKFCFPDSKDWMPTSELKSETFSFVLTGEDGSRWFGYCKKLLPVGKG 584
            .|||||||||.||||||||:||||||:|..||.||||||||||||||||||||||||||||.|:|
  Rat   515 GDHGYKQSKDTEERLKVIPRFCFPDSEDCAPTLELKSETFSFVLTGEDGSRWFGYCKKLLPEGRG 579

Human   585 KRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGA 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   580 KRLPEVYCMVSRLGCFNLFSKILDEVEKRREMSPALVYPFMRSVMEAPFPAPGRTITVKSYLPGA 644

Human   650 GDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVAT 714
            ||||||||||||||||||||:||||||||.|||||||||||||||||||:|||||||||||||||
  Rat   645 GDESIELCRPLDSRLEHVDFECLFKCLSVRHLIRVCASLLLERRVIFVADSLSTLSKCGHAVVAT 709

Human   715 LYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDE 779
            |||||||||||||||.||||||||||||.|||||||||.||||||||||||||||||||||||||
  Rat   710 LYPFTWQHTYIPVLPVSMIDIVCSPTPFFIGILSCSLPLLQDLPIEEVLIVDLCADKFLQEVSDE 774

Human   780 DEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGE 844
            |||:||||||||:||||||:|:|.||:.|||||||||||||||||||||||||||||||||||||
  Rat   775 DEIMPPKLQAALVQILEERDEVLAQERQFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGE 839

Human   845 RVFQREPFRKSHTSRSVRHFLDLFMETQMFAGFIQDRELRKSGVKGLFEIRAIQYLETIPESEPS 909
            |||.|||||||||||||||||||||||||||||:||||||:||||||||:||:||||||||||||
  Rat   840 RVFLREPFRKSHTSRSVRHFLDLFMETQMFAGFVQDRELRQSGVKGLFEVRALQYLETIPESEPS 904

Human   910 GMNRILRSLGSKMKFLQKK 928
            |:|||||||||||:||.||
  Rat   905 GVNRILRSLGSKMRFLHKK 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105		12/37 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266		16/20 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456		22/27 (81%)
		uDENN	487..576	CDD:214824	75/88 (85%)
		DENN	586..770	CDD:280329	177/183 (97%)
		dDENN	815..881	CDD:129037	63/65 (97%)
Dennd2c	NP_001178498.1	uDENN	482..571	CDD:214824	75/88 (85%)
		DENN	581..765	CDD:396629	177/183 (97%)
		dDENN	810..876	CDD:129037	63/65 (97%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83684419
Domainoid	1	1.000	767	1.000	Domainoid score	I2935
eggNOG	1	0.900	-	-		E1_KOG3569
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H19542
Inparanoid	1	1.050	1547	1.000	Inparanoid score	I2559
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39929
OrthoDB	1	1.010	-	-		D11393at314146
OrthoFinder	1	1.000	-	-		FOG0001293
OrthoInspector	1	1.000	-	-		oto131951
orthoMCL	1	0.900	-	-		OOG6_105255
Panther	1	1.100	-	-	LDO	PTHR15288
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X8674
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270