DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and SPCC297.05

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_588362.1	Gene:	SPCC297.05 / 2539220	PomBaseID:	SPCC297.05	Length:	973	Species:	Schizosaccharomyces pombe

Alignment Length:	697	Identity:	151/697 - (21%)
Similarity:	259/697 - (37%)	Gaps:	188/697 - (26%)

- Green bases have known domain annotations that are detailed below.

Human   213 PRRTF-RYLSESGVTPYKERNCDKKYCENNSCAQSSLASSQEPEPKKYGGKIRGRSKRKSF---E 273
            |::.| .|...:..||.|::.....:....|..:.|| ||....|:||       ..||.:   .
pombe    81 PKKPFLDYHHSTSNTPTKKKKDSFDHASVTSLHRRSL-SSNTSTPRKY-------HSRKPYSEPS 137

Human   274 FEDIQHFRNRNSQTIREELGRNSGSALYYTQSEDNIYED-IIYP------TKENPYEDIPVQPLP 331
            ..|.:|.:||.|      :|.        |.:::::|:. :.||      ...:|:|. ...|..
pombe   138 VIDKEHLQNRVS------IGT--------THTQNDLYQSYVAYPDALPLFAATHPFER-RYPPSL 187

Human   332 MWRSPSAWKL---PPAKSAFKAPKLPPK---PQFLHRKTMEVKNSQAYLRSKLTKD--------- 381
            :.:.||:..:   .|.......|...|.   |..:..|..:|:....|....||.|
pombe   188 LHQFPSSKDIKNETPTIDRCDFPNYVPMFAFPNDITIKESDVRPVSTYHSFALTSDNNSHLYGIC 252

Human   382 ----TTLPVTL-----TEWKLFRAGEVANTKRKNLPRLVLKIDDIFESKRGKKKVKLHSYTGKEL 437
                ..:|.::     .|.:::||.......|:...:|:..:    |::|.|....|.....|||
pombe   253 VVVWVAMPQSMQNDLEKECEVWRANNTTVEDREVAEKLLSSL----ETERSKLSSLLLKMQEKEL 313

Human   438 PPTKGETSGNES-DAEYLPKNRHKRLAQLQPSSKRNPHYQTLERDLI---ELQEQQLFEL--FVV 496
                   .|::| |...|.|                  ....|.::|   ||.....::|  ||
pombe   314 -------EGSDSIDPILLEK------------------IDVCEENIILYTELLRPMRYKLPRFV- 352

Human   497 VSLQKKPSGIS-----YIPQVIQQFPGKDDHGYKQSKDMEERLKVIPKFCFPDSKDWM--PTSEL 554
                   .|::     :||..   :.....|.:.||            ||    :||:  ..|.:
pombe   353 -------HGLTNNRTLWIPNA---YGLLSKHSHLQS------------FC----RDWLRIVCSSI 391

Human   555 KSETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYCMVSRLGC-FNLFSKILDEVEKRREMSP 618
            ::|...|:.:.:..|     .|.|          .:...|..:.| ..|..|.|  ::.:..:.|
pombe   392 QAEDLDFIPSSDLNS-----LKSL----------NLQSFVKNICCDVPLPPKGL--LQLQVNVGP 439

Human   619 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLFKCLSVCHLIR 683
            ..:|.|...|.|               :||..|               ||...||:.||:.:::.
pombe   440 LNLYAFRSPVNE---------------IPGWND---------------VDLYPLFRALSIPNILV 474

Human   684 VCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILS 748
            :..:.|:|.:|||::.:|..|.....|::..|||.|||..||||||..:|....:|..::||.||
pombe   475 LFEAALMEAKVIFLSENLGMLGYASQALLHLLYPLTWQGLYIPVLPRRLISCFEAPCSYIIGTLS 539

Human   749 CSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEI------LPPKLQA--ALMQILEERNEILTQE 805
            ... .:.|:|::.:.:|....||  ..||...:|      |..||||  .|...|.::..:....
pombe   540 YFF-HMDDVPLDNIPLVVCDLDK--NSVSTFGKIVRLSRSLRSKLQAHLKLAAPLHDKFYVPHSP 601

Human   806 QNFSQDVTLNSLVSEAFVRFFVELVGHYSLNMTVTERGERVFQREPF 852
            ..::.:...|:::|.:.|..| .|...:|:...::.|... |.:.|:
pombe   602 PKYTMETYPNNVLSLSTVTCF-PLREKFSIPALLSFRSSN-FSKRPY 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456		8/28 (29%)
		uDENN	487..576	CDD:214824	17/97 (18%)
		DENN	586..770	CDD:280329	48/184 (26%)
		dDENN	815..881	CDD:129037	9/38 (24%)
SPCC297.05	NP_588362.1	uDENN	174..256	CDD:214824	15/82 (18%)
		DENN	362..562	CDD:280329	65/268 (24%)
		dDENN	833..911	CDD:129037
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001293
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.030