DRSC/TRiP Functional Genomics Resources

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Protein Alignment DENND2C and rme-4

DIOPT Version :10

Sequence 1:NP_001243333.1 Gene:DENND2C / 163259 HGNCID:24748 Length:928 Species:Homo sapiens
Sequence 2:NP_001359519.1 Gene:rme-4 / 185870 WormBaseID:WBGene00004375 Length:663 Species:Caenorhabditis elegans


Alignment Length:426 Identity:112/426 - (26%)
Similarity:174/426 - (40%) Gaps:90/426 - (21%)


- Green bases have known domain annotations that are detailed below.


Human   534 LKVIPKFCFPDSKDWMPTSELKS------ETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYC 592
            :|.:.:|.||        .:|:.      :.||||||..:....||:|:..      .|.....|
 Worm    46 VKSVQQFAFP--------CQLREVEVDAVQLFSFVLTDSNSKFSFGFCRYT------PRTDTCIC 96

Human   593 MVSRLGCFNLFSKILDEV-----EKRREMSPALVYPFMRSVMEAP-------FPAPGRT------ 639
            .:|.....|:|.|.|:::     ..:||...:::..|..:  :.|       |....:|      
 Worm    97 FLSGFFWPNVFFKALNDISLVIGSAQREDVESVLTKFYHT--DIPNIDEYLRFADSNQTDGHNYR 159

Human   640 ------ITVKSYLPGAGDES--IELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIF 696
                  |...:.||..|.:.  :|....:|.|                .::.:.||||.|||::|
 Worm   160 VVFAEKIPDHTRLPTLGSDKFFLEFYNAIDPR----------------QMLAIFASLLKERRILF 208

Human   697 VANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSL--PQLQDLPI 759
            ....:.:||.|.|||...|||..||..:|.:||.|::|:|.:|.|:|||:....|  .:|....|
 Worm   209 TGRKVGSLSSCLHAVSMLLYPMCWQSVFITILPESLVDMVMAPMPYLIGVPKTVLENARLNIRDI 273

Human   760 EEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVR 824
            .||:|||: .:|.|....|:...:|.::...|...|..::             .::...::.|:|
 Worm   274 GEVVIVDI-DEKTLTSPFDDVAAMPQEVVNFLKAQLRSQS-------------AMDDTFAKHFLR 324

Human   825 FFVELVGHYSLNMTVTERGERVFQREPF---RKSHTSRSVRHFLDLFMETQMFAGFIQDR-ELRK 885
            ..|.|.|.|:...|.......||.:|.|   :|......|...|.. ...|....||.|| ||.|
 Worm   325 AMVMLFGDYTSGFTGDTPETLVFSKERFVVQQKPSYQAYVSSLLGA-DGVQYLERFIHDRLELYK 388

Human   886 SG-VKG-LFEIRAIQY-LETIPESEPSGMNRILRSL 918
            .| |.| .|||...|. |:..|..|  ..|.::.:|
 Worm   389 DGHVPGDQFEIEIEQMDLKNRPVKE--NANDVIGAL 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DENND2CNP_001243333.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..105
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 245..266
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..456
uDENN 487..576 CDD:214824 13/47 (28%)
DENN 586..770 CDD:460461 58/211 (27%)
dDENN 815..881 CDD:129037 17/68 (25%)
rme-4NP_001359519.1 uDENN 12..86 CDD:214824 13/47 (28%)
DENN 91..282 CDD:214823 57/209 (27%)
dDENN 315..383 CDD:129037 17/68 (25%)
Blue background indicates that the domain is not in the aligned region.

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