DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DENND2C and rme-4

DIOPT Version :9

Sequence 1:	NP_001243333.1	Gene:	DENND2C / 163259	HGNCID:	24748	Length:	928	Species:	Homo sapiens
Sequence 2:	NP_001359519.1	Gene:	rme-4 / 185870	WormBaseID:	WBGene00004375	Length:	663	Species:	Caenorhabditis elegans

Alignment Length:	426	Identity:	112/426 - (26%)
Similarity:	174/426 - (40%)	Gaps:	90/426 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   534 LKVIPKFCFPDSKDWMPTSELKS------ETFSFVLTGEDGSRWFGYCKKLLPVGKGKRLPEVYC 592
            :|.:.:|.||        .:|:.      :.||||||..:....||:|:..      .|.....|
Worm    46 VKSVQQFAFP--------CQLREVEVDAVQLFSFVLTDSNSKFSFGFCRYT------PRTDTCIC 96

Human   593 MVSRLGCFNLFSKILDEV-----EKRREMSPALVYPFMRSVMEAP-------FPAPGRT------ 639
            .:|.....|:|.|.|:::     ..:||...:::..|..:  :.|       |....:|
Worm    97 FLSGFFWPNVFFKALNDISLVIGSAQREDVESVLTKFYHT--DIPNIDEYLRFADSNQTDGHNYR 159

Human   640 ------ITVKSYLPGAGDES--IELCRPLDSRLEHVDFKCLFKCLSVCHLIRVCASLLLERRVIF 696
                  |...:.||..|.:.  :|....:|.|                .::.:.||||.|||::|
Worm   160 VVFAEKIPDHTRLPTLGSDKFFLEFYNAIDPR----------------QMLAIFASLLKERRILF 208

Human   697 VANSLSTLSKCGHAVVATLYPFTWQHTYIPVLPASMIDIVCSPTPFLIGILSCSL--PQLQDLPI 759
            ....:.:||.|.|||...|||..||..:|.:||.|::|:|.:|.|:|||:....|  .:|....|
Worm   209 TGRKVGSLSSCLHAVSMLLYPMCWQSVFITILPESLVDMVMAPMPYLIGVPKTVLENARLNIRDI 273

Human   760 EEVLIVDLCADKFLQEVSDEDEILPPKLQAALMQILEERNEILTQEQNFSQDVTLNSLVSEAFVR 824
            .||:|||: .:|.|....|:...:|.::...|...|..::             .::...::.|:|
Worm   274 GEVVIVDI-DEKTLTSPFDDVAAMPQEVVNFLKAQLRSQS-------------AMDDTFAKHFLR 324

Human   825 FFVELVGHYSLNMTVTERGERVFQREPF---RKSHTSRSVRHFLDLFMETQMFAGFIQDR-ELRK 885
            ..|.|.|.|:...|.......||.:|.|   :|......|...|.. ...|....||.|| ||.|
Worm   325 AMVMLFGDYTSGFTGDTPETLVFSKERFVVQQKPSYQAYVSSLLGA-DGVQYLERFIHDRLELYK 388

Human   886 SG-VKG-LFEIRAIQY-LETIPESEPSGMNRILRSL 918
            .| |.| .|||...|. |:..|..|  ..|.::.:|
Worm   389 DGHVPGDQFEIEIEQMDLKNRPVKE--NANDVIGAL 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DENND2C	NP_001243333.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..105
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..266
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..456
		uDENN	487..576	CDD:214824	13/47 (28%)
		DENN	586..770	CDD:280329	58/211 (27%)
		dDENN	815..881	CDD:129037	17/68 (25%)
rme-4	NP_001359519.1	uDENN	12..86	CDD:214824	13/47 (28%)
		DENN	91..282	CDD:214823	57/209 (27%)
		dDENN	315..383	CDD:129037	17/68 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910