DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DCC and robo1

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_476899.1 Gene:robo1 / 37603 FlyBaseID:FBgn0005631 Length:1395 Species:Drosophila melanogaster


Alignment Length:1541 Identity:366/1541 - (23%)
Similarity:543/1541 - (35%) Gaps:426/1541 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQ---QLSNGSLLIQNI 102
            |.:..|:|.|..:.....|:|..|. :..|.|:|.|||  ..:..:|:|.   |..:|:|.....
  Fly    57 RIIEHPTDLVVKKNEPATLNCKVEG-KPEPTIEWFKDG--EPVSTNEKKSHRVQFKDGALFFYRT 118

Human   103 LHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGDTVLLKC-EVI 164
            :..:..: |.|.|.|.|. ...|..:||.|.:.:| .||  |..:.:......|:|.||:| ...
  Fly   119 MQGKKEQ-DGGEYWCVAK-NRVGQAVSRHASLQIA
-VLRDDFRVEPKDTRVAKGETALLECGPPK 180

Human   165 GEPMPTIHWQKNQQDLTPIP-----GDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGN 224
            |.|.||:.|.|:...|..:.     ..|||.::..|.|.||.::|.|.|.|:|.|:|...:|..:
  Fly   181 GIPEPTLIWIKDGVPLDDLKAMSFGASSRVRIVDGGNLLISNVEPIDEGNYKCIAQNLVGTRESS 245

Human   225 EAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSL 289
            .|::.:...|      ||::.|.:.|.:.|:.|...|.|.|.|||...|.:.|..|.: |:...|
  Fly   246 YAKLIVQVKP------YFMKEPKDQVMLYGQTATFHCSVGGDPPPKVLWKKEEGNIPV-SRARIL 303

Human   290 LGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTV 354
            ....:|.|||:|..|.|.|.|........|||.|.|.|..||.|...|||.....:..::..|..
  Fly   304 HDEKSLEISNITPTDEGTYVCEAHNNVGQISARASLIVHAPPNFTKRPSNKKVGLNGVVQLPCMA 368

Human   355 SGKPVPTVNWMKNG--DVVIPSDYF---QIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQ 414
            ||.|.|:|.|.|.|  .::.|:...   .:.....|:|..|.:.|||:|.|.|.:          
  Fly   369 SGNPPPSVFWTKEGVSTLMFPNSSHGRQHVAADGTLQITDVRQEDEGYYVCSAFS---------- 423

Human   415 LIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNT 479
                  .:.||:|.       |.:.|||    |..|||.                          
  Fly   424 ------VVDSSTVR-------VFLQVSS----LDERPPP-------------------------- 445

Human   480 TQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTSPTSI 544
                .:|:                     ||...:.|           .|.|..|...:|...|.
  Fly   446 ----IIQI---------------------GPANQTLP-----------KGSVATLPCRATGNPSP 474

Human   545 LITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVS 609
            .|.|....:|             |..|...:| :.|.|.:::.|:                    
  Fly   475 RIKWFHDGHA-------------VQAGNRYSI-IQGSSLRVDDLQ-------------------- 505

Human   610 TDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETL 674
                    |||                           |||.....:|         .|||..  
  Fly   506 --------LSD---------------------------SGTYTCTASG---------ERGETS-- 524

Human   675 EPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRPQTN 739
                 |.....:||....|...:|       .||   |...|         |..|..|:|  ...
  Fly   525 -----WAATLTVEKPGSTSLHRAA-------DPS---TYPAP---------PGTPKVLNV--SRT 563

Human   740 CIIMSWTPPL-NPNIVVRGYIIGYGVG--SPYAETVRVDSKQR----YYSIERLESSSHYVISLK 797
            .|.:.|.... .|..|  |.||||.|.  ||..:|..:.:.||    ..:|..|...:.||..::
  Fly   564 SISLRWAKSQEKPGAV--GPIIGYTVEYFSPDLQTGWIVAAQRVGDTQVTISGLTPGTSYVFLVR 626

Human   798 AFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVG-----VQAVALTH 857
            |.|..|..||...|.|.::|....|           ..|..|||.......|     :.|.|:..
  Fly   627 AENTQGISVPSGLSNTIKTIEADFD-----------AASANDLSAARTLLTGKSVELIDASAINA 680

Human   858 DAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKS---EDTTSLSYTATGLKPNTMYEFS 919
            .|||:.|..:.....:....:|::   ::.:...||:|.|   .|.::.|:....||..|.|||.
  Fly   681 SAVRLEWMLHVSADEKYVEGLRIH---YKDASVPSAQYHSITVMDASAESFVVGNLKKYTKYEFF 742

Human   920 VMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREG--KPRAVIVSWQPP--LEANGKITAY 980
            :...........|.:..|.|||..|::.|.::.:    |  ...|..|.|.||  ...||.:..|
  Fly   743 LTPFFETIEGQPSNSKTALTYEDVPSAPPDNIQI----GMYNQTAGWVRWTPPPSQHHNGNLYGY 803

Human   981 ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDT--MYYFRIQARNSKGVGPLSDPI-LFR-- 1040
            .:..:....:.    ::..::.:..|..::..||.|  :|..|:.:....|.||.|.|| ||.  
  Fly   804 KIEVSAGNTMK----VLANMTLNATTTSVLLNNLTTGAVYSVRLNSFTKAGDGPYSKPISLFMDP 864

Human  1041 TLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHP-PHGSVTPQKNSNLLVIIVV 1104
            |..| ||.: |:..|.| ||.:...|  |...:..|.|| |.::| .|...|...:...|:::| 
  Fly   865 THHV-HPPR-AHPSGTH-DGRHEGQD--LTYHNNGNIPP-GDINPTTHKKTTDYLSGPWLMVLV- 922

Human  1105 TVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKG-----SQKDL------RPPDLWI-HH 1157
               .|.:||:||.|.|    |....::|   |...|..|     |..::      ....||| ||
  Fly   923 ---CIVLLVLVISAAI----SMVYFKRK---HQMTKELGHLSVVSDNEITALNINSKESLWIDHH 977

Human  1158 EEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLE- 1221
            ......:.:|.||         :...:.|:.|:.|||........|.::..||.    :::|.. 
  Fly   978 RGWRTADTDKDSG---------LSESKLLSHVNSSQSNYNNSDGGTDYAEVDTR----NLTTFYN 1029

Human  1222 -RSLAARRAPRAKLMI-----------------PMDAQSNNP------AVVSAIPVPTLESAQYP 1262
             |.......|.|..||                 ..|:.:::|      ..|.|:||......|||
  Fly  1030 CRKSPDNPTPYATTMIIGTSSSETCTKTTSISADKDSGTHSPYSDAFAGQVPAVPVVKSNYLQYP 1094

Human  1263 -------GILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAG-------RSQSVSEGPTTQQPPML 1313
                   ..||.|. .:|.|..|.            |:..|       .|:|...|.:|.|..: 
  Fly  1095 VEPINWSEFLPPPP-EHPPPSSTY------------GYAQGSPESSRKSSKSAGSGISTNQSIL- 1145

Human  1314 PPSQPEHSSSE-------EAPSRTIPTACVRPTHPLRSFANPLLP-----------PPMSAIEPK 1360
              :...||||.       .:|...:  ||    .|...::|||..           .|.:...|:
  Fly  1146 --NASIHSSSSGGFSAWGVSPQYAV--AC----PPENVYSNPLSAVAGGTQNRYQITPTNQHPPQ 1202

Human  1361 VPYTPLLSQPGPTLPKTHVK-----------TASLGLAGKARS----------------PLLPVS 1398
            :|.....:.||..:|..|:.           .|.|..|..|:|                |..||.
  Fly  1203 LPAYFATTGPGGAVPPNHLPFATQRHAASEYQAGLNAARCAQSRACNSCDALATPSPMQPPPPVP 1267

Human  1399 VPTA--PEVSEESH--KPTEDSANVYE-QDDLSEQMASLEGLMKQL 1439
            ||..  ..|...||  .||..:..:|: ..:.|:...|.:...:||
  Fly  1268 VPEGWYQPVHPNSHPMHPTSSNHQIYQCSSECSDHSRSSQSHKRQL 1313

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 27/97 (28%)