DRSC/TRiP Functional Genomics Resources

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Protein Alignment DCC and tei

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_523731.2 Gene:tei / 36521 FlyBaseID:FBgn0000633 Length:822 Species:Drosophila melanogaster


Alignment Length:661 Identity:141/661 - (21%)
Similarity:227/661 - (34%) Gaps:180/661 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   123 DSGSIISRTAKVAVAGPLRFLSQTESVT-AFMGDTVLLKCEVIGEPMPTIHWQKNQQ-----DLT 181
            |.|.:..|...:....|..:.::..||. |.....:.|.||| ...:.|..|.||.|     |.|
  Fly   219 DEGPLEPRVLPLRPVPPNPYEAEEMSVVYAEQHSEIKLMCEV-DLDIATSMWYKNGQVVHAMDRT 282

Human   182 PIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRP 246
            ....|.|.:...:|||.|:.:...|.|.::|.|.| ....|.|...|:          |..|.||
  Fly   283 ARVTDYRFIKEANGALTITNVMLEDDGKWQCEAEN-TRRYTENARPVK----------LVVLDRP 336

Human   247 --------------SNV-VAIEGKDAVLECCVS--GYPPPSFTW-------------LRGEEVIQ 281
                          ||: |.::....:...|||  |.|.|:.||             ....||::
  Fly   337 KPPYLLIDSRRLDASNLFVPVKENSELNLACVSEGGNPRPTLTWEVLLSPGVDRHAQKVSAEVLE 401

Human   282 LRSKKYSLLGGSNLLISNVTDDDSGM-----------YTCVVTYKNENI--SASAELTVLVPPWF 333
            |...|...|......|::....::.:           ..||:.:....|  :||..|.|...|.|
  Fly   402 LEEIKGEKLDKDGYKINSGAKSEARLPAVYRAHHNARILCVMEHPTLKIRQNASLLLDVQYTPSF 466

Human   334 LNHPSNLYAY---ESMDIEFECTVSGKPVPTVNWMK-NGDVVIPSDYFQIVGGSNLRILGVVKSD 394
            ....:..:.|   |.:::..:|.|...|..|..|.| :||..:|.     .|...|....:.:..
  Fly   467 AISRTPGFGYPLREGIEVSLKCDVDSNPPSTPRWQKDDGDTPVPQ-----TGDGFLNFTSIRREH 526

Human   395 EGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRF--VRLSWRPPAEAKG 457
            .|:|:|.:.:.  |.|.|:                      :...:|.||  |.::..|      
  Fly   527 SGWYKCTSRHL--NFQYSS----------------------IGYYLSVRFDSVDVTSEP------ 561

Human   458 NIQTFTVFFSREGDNRER-------ALNTTQP-GSL--------------QLTVGNLKPEAMYTF 500
            :.|..:|..:....|:.:       |:....| |||              .|..|:.:|...::.
  Fly   562 DDQDVSVAAASHNPNKGQLEVQLGGAVTLQCPQGSLGCWSHLDPISARLRGLGYGSSQPTGQFSL 626

Human   501 RVVAYNEWG----PGESSQPIKVATQPELQVPGPVENLQAVSTS----PTSILITWEPPAYANGP 557
            :.|.|.:.|    .|:|.     ..:.:|:|      ||:|:.|    ||.:.:...|.||...|
  Fly   627 KDVMYQDAGMYKCVGQSP-----TNKKKLEV------LQSVTVSVKGAPTVMALNATPVAYPGSP 680

Human   558 VQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFT---EYSLRFLAYNRYGPGVSTDDITVVTLS 619
            :.....||.        |.......: |.|.:.||   :|....|||               .:.
  Fly   681 LHLNVEFCA--------NPPAHAARW-LHGDRVFTPGNQYGTTVLAY---------------AVK 721

Human   620 DVPSAPPQNVSLEVV--NSRSIKVSW--LPPPSGTQNG-FITGYKIRHRKTTRR----GEMETLE 675
            |:|:...:...|..|  :.|..:..:  :..|.|.... |...:..|||:.:..    .|.|...
  Fly   722 DLPTPFCKEARLTYVSMHERVPRTFYFIVSTPGGVAEAIFNVNFTKRHRQLSNSIDDDEEEELNR 786

Human   676 PNNLWY-LFTG 685
            |..:.: :|.|
  Fly   787 PEQIHFPVFNG 797

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 3/12 (25%)
Ig strand A 39..42 CDD:409387
Ig strand A' 45..51 CDD:409387
Ig strand B 55..65 CDD:409387
Ig strand C 70..76 CDD:409387
Ig strand C' 78..81 CDD:409387
Ig strand D 88..93 CDD:409387
Ig strand E 95..101 CDD:409387
Ig strand F 113..120 CDD:409387
Ig strand G 125..136 CDD:409387 2/10 (20%)
Ig_3 139..216 CDD:464046 25/82 (30%)
I-set 241..327 CDD:400151 26/128 (20%)
Ig strand B 257..261 CDD:409562 0/3 (0%)
Ig strand C 270..274 CDD:409562 2/16 (13%)
Ig strand E 293..297 CDD:409562 0/3 (0%)
Ig strand F 307..312 CDD:409562 1/15 (7%)
Ig strand G 322..325 CDD:409562 1/2 (50%)
Ig 334..417 CDD:472250 19/86 (22%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 1/3 (33%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 1/2 (50%)
FN3 429..521 CDD:238020 21/119 (18%)
FN3 <478..901 CDD:442628 51/244 (21%)
FN3 946..1041 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152
Neogenin_C 1148..1445 CDD:461954
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
teiNP_523731.2 IG_like 244..332 CDD:214653 29/99 (29%)
Ig strand B 254..258 CDD:409353 1/3 (33%)
Ig strand C 267..271 CDD:409353 1/3 (33%)
Ig strand E 296..300 CDD:409353 3/3 (100%)
Ig strand F 310..315 CDD:409353 1/4 (25%)
Ig strand G 326..329 CDD:409353 0/2 (0%)
Ig 359..452 CDD:472250 17/92 (18%)
Ig_3 478..533 CDD:464046 14/59 (24%)
IG_like 578..660 CDD:214653 18/92 (20%)
Blue background indicates that the domain is not in the aligned region.

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