DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DCC and fra

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster


Alignment Length:1699 Identity:495/1699 - (29%)
Similarity:738/1699 - (43%) Gaps:437/1699 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     4 SLRCVW----VPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCS-- 62
            |.|.:|    ...|.|.|.|:||             |..||.|..||.|||...|.:|||.|:  
  Fly     8 SSRTLWNWLLSSCLIFQLIGSSL-------------ASQALSFTLEPQDAVVPEGHSVLLQCAGT 59

Human    63 ------AESDRGVP---VIKWK-KDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQC 117
                  .:|...:|   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||
  Fly    60 ASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQC 121

Human   118 EASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFM------GDTVLLKCEVIGEPMPTIHWQKN 176
            ..:....|||:||.|.||:      :.|.:....|:      |.|...:| ::||    .:||:.
  Fly   122 LLTAEGVGSILSRPALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEG 175

Human   177 --------QQDLTPIPGDS-RVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRIL- 231
                    :.|| |:|.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|||..::..:.|. 
  Fly   176 VKHSVQWLKDDL-PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKK 239

Human   232 -SDPGLHRQL--YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLG 291
             ||||....:  .||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|
  Fly   240 PSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVG 304

Human   292 GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSG 356
            ..:|.||:..|.|||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|
  Fly   305 TGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWG 369

Human   357 KPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL-IVPK- 419
            ||.|.:.|:||||::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:...:|:| :||: 
  Fly   370 KPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQG 434

Human   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   435 VKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIP 499

Human   420 ----------------------------------------------------------------- 419
                                                                             
  Fly   500 SGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKIL 564

Human   420 -----------------PAIPSS-----SV---------------LPSAPRDVVPVLVSSRFVRL 447
                             ||.|.|     ||               |||.|||:|..:|.||||.|
  Fly   565 DSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTL 629

Human   448 SWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512
            ||..|.:..|::..:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.
  Fly   630 SWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGA 694

Human   513 SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIE 577
            ||.|::|:||||:.:.||..|.:..:.|...|.:.||.|...||.:..||::.:|..:|.:...:
  Fly   695 SSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHD 759

Human   578 VDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642
            ...|...|..|:..|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.||:|||.:|.||.|.
  Fly   760 STALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVH 824

Human   643 WLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
            |.||....:||.|||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.
  Fly   825 WEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPF 889

Human   708 SNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETV 772
            :.|..|.|.||||||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:
  Fly   890 TEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTI 954

Human   773 RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSV 837
            .:...:||:.::.|||:..||:||:|.|..|:|.|:|::..||               |:.|...
  Fly   955 ELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDA 1004

Human   838 PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTS 902
            |   ||:..|||::|:.::..::.|.|.|..:.|||..::.|.|||.:  ..:.|.:|:..:||.
  Fly  1005 P---TPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTD 1064

Human   903 LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSW 967
            |:.....|:|||.|||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|
  Fly  1065 LNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQW 1129

Human   968 QPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGV-- 1030
            .||....|:||.|.::||.|......||.:|..:|:.....:.:|...|.|||::|||.:||.  
  Fly  1130 IPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANN 1194

Human  1031 GPLSDPILFRT---LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTP 1092
            .|.|..:.:.|   :.::.||.:|..                ||                     
  Fly  1195 APFSALVSYTTSAAVTMQEPDTIAKG----------------ID--------------------- 1222

Human  1093 QKNSNLLVIIVVTVGVITVLVVVIVAVICTRR--SSAQQRKKRATHSAGKRKGSQKDLRPPDLWI 1155
              |..||.||:....|:.::|::.|.::|.|:  ||.:..||      ..:|.:....:||||||
  Fly  1223 --NEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWI 1279

Human  1156 HHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTL 1220
            ||::||:|||:|...|              :|||.         |...|.||         ..||
  Fly  1280 HHDQMELKNIDKGLHT--------------VTPVC---------SDGASSSG---------ALTL 1312

Human  1221 ERSLAARRAPRAKLMIP------MDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTL 1279
            .||: .......:..:|      :|.:|..|..::.....|:|..||      |...|.|     
  Fly  1313 PRSV-VHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQY------PRTQYSH----- 1365

Human  1280 RPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQ-----PEH------SSSEEAPSRTIPT 1333
                           ..||....|...:||....|.|.     |||      ::...|.:.....
  Fly  1366 ---------------QNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGN 1415

Human  1334 ACV------RPTHPLRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKAR 1391
            .||      :..|||:||:.| .|||.....|...:||.:: :|....|              .:
  Fly  1416 GCVSTIESSKRGHPLKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YK 1465

Human  1392 SPLLPVSVPT------------------APEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQ 1438
            .|....:.|.                  ||..|.|               :|:::||:||||||.
  Fly  1466 KPSFSAATPNRLQGGGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKD 1515

Human  1439 LNAITGSAF 1447
            |:|||.:.|
  Fly  1516 LSAITANEF 1524

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 40/108 (37%)
Ig strand A 39..42 CDD:409387 2/2 (100%)
Ig strand A' 45..51 CDD:409387 4/5 (80%)
Ig strand B 55..65 CDD:409387 4/17 (24%)
Ig strand C 70..76 CDD:409387 3/9 (33%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 1/4 (25%)
Ig strand E 95..101 CDD:409387 4/5 (80%)
Ig strand F 113..120 CDD:409387 4/6 (67%)
Ig strand G 125..136 CDD:409387 7/10 (70%)
Ig_3 139..216 CDD:464046 28/91 (31%)
I-set 241..327 CDD:400151 27/87 (31%)
Ig strand B 257..261 CDD:409562 1/3 (33%)
Ig strand C 270..274 CDD:409562 0/3 (0%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 2/4 (50%)
Ig strand G 322..325 CDD:409562 1/2 (50%)
Ig 334..417 CDD:472250 36/83 (43%)
Ig strand B 348..352 CDD:409388 1/3 (33%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 2/3 (67%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 429..521 CDD:238020 35/91 (38%)
FN3 <478..901 CDD:442628 151/422 (36%)
FN3 946..1041 CDD:238020 34/96 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152 5/25 (20%)
Neogenin_C 1148..1445 CDD:461954 83/338 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 12/56 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330 11/52 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419 5/42 (12%)
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439 6/6 (100%)
fraNP_523716.2 Ig 34..140 CDD:472250 40/108 (37%)
Ig strand B 52..56 CDD:409387 3/3 (100%)
Ig strand C 77..81 CDD:409387 1/3 (33%)
Ig strand E 102..106 CDD:409387 3/3 (100%)
Ig strand F 118..123 CDD:409387 3/4 (75%)
Ig strand G 133..136 CDD:409387 2/2 (100%)
Ig <178..222 CDD:472250 19/44 (43%)
Ig strand C 179..183 CDD:409550 0/3 (0%)
Ig strand E 202..206 CDD:409550 3/3 (100%)
Ig strand F 216..221 CDD:409550 2/4 (50%)
Ig_3 251..327 CDD:464046 25/75 (33%)
Ig 347..428 CDD:472250 35/80 (44%)
Ig strand B 361..365 CDD:409388 1/3 (33%)
Ig strand C 374..378 CDD:409388 0/3 (0%)
Ig strand E 396..400 CDD:409388 2/3 (67%)
Ig strand F 410..415 CDD:409388 2/4 (50%)
Ig strand G 423..426 CDD:409388 0/2 (0%)
FN3 611..703 CDD:238020 35/91 (38%)
FN3 <676..1068 CDD:442628 151/411 (37%)
FN3 1109..1205 CDD:238020 34/95 (36%)
Neogenin_C 1273..1521 CDD:461954 82/336 (24%)

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