Protein Alignment DCC and ihog

DIOPT Version :10

• Sequence 1: NP_005206.2
• Gene: DCC / 1630
• HGNCID: 2701
• Length: 1447
• Species: Homo sapiens
• Sequence 2: NP_609085.1
• Gene: ihog / 33972
• FlyBaseID: FBgn0031872
• Length: 886
• Species: Drosophila melanogaster
• Alignment Length: 922
• Identity: 212/922 - (22%)
• Similarity: 344/922 - (37%)
• Gaps: 199/922 - (21%)

Human    40 LRFLSEPSDAVTMRGGNVLLDC-----------SAESDRGVPV-IKWKKDGIHLALGMDERKQQL 92
            :|.|..|...|...|..|:|:|           |..|.|.... .|:.|.|  .|.....::..:
  Fly    53 VRILRAPESLVAPLGDEVVLECETSLQPERFEWSHRSSRSPGAGFKYLKTG--TAKANVSQEAAI 115

Human    93 SNGSLLIQNILHSRHHKPDE-GLYQCEASLGDSGSII--SRTAKVAVAG-PLRFLSQTES----- 148
            |...:|:         :||. |.|:|   :|..|.::  |..|::.:|. .|....::||
  Fly   116 SRLRVLV---------RPDTLGEYRC---VGWFGPLVVTSTIARLELASTSLVDAQESESPLQWR 168

Human   149 VTAFMGDTVLLKC--EVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYR 211
            |:|  |::||..|  :|...|..:..:.:|..::.|      ..:..:|.|.:|.:.....|.|.
  Fly   169 VSA--GNSVLWSCGQQVQSNPSASWSYYRNGVEIKP------EFIGTNGNLFLSNVSSESSGSYS 225

Human   212 CSARNPASSRTGNEAEVRILSDPGLHRQLYFLQR------------PSN--VVAIEGKDAVLECC 262
            |.|.||||..       ||.....|..|:...||            ||:  :...||...:|.|.
  Fly   226 CQATNPASGE-------RIQLPGSLQLQVTPEQRSESKSPHLLRGQPSSQEITIREGSSLLLLCP 283

Human   263 VSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTV 327
            ..|.|||:..|...:.|..:::|:..:.|.: |.|||...:|:|.|.|   :::..:..:.|..:
  Fly   284 GVGSPPPTVVWSSPDVVGAVKNKRSKVFGHA-LEISNTRVNDAGTYIC---FQDNGVRPALEHYI 344

Human   328 LV----PPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRIL 388
            .|    ||..:..|......|...::.||..:|.|.|.:.|:.||...|.....::  .:|..||
  Fly   345 KVHVEQPPQIVRPPWADLTNEGDRLKLECKATGVPTPEIYWLLNGHSSIDDSEAEL--SNNFLIL 407

Human   389 -GVVKSDEGFYQCVAENEAGNAQTSAQLIV----------------PKPAIPS--SSVLPSAPRD 434
             .|:|...|:.||.|.|..|.......|.|                |||...|  ..:.|..|.:
  Fly   408 HSVLKRHAGYVQCFARNRLGEHSAGTLLQVNPKQIQEPRESGGTHRPKPNQGSRQKQMYPPTPPN 472

Human   435 VVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRE-RALNTTQP-----------GSLQL 487
            |  ..:|...|.|.|..|......|..|.|.:...|..:. :..|...|           .|...
  Fly   473 V--TRLSDESVMLRWMVPRNDGLPIVIFKVQYRMVGKRKNWQTTNDNIPYGKPKWNSELGKSFTA 535

Human   488 TVGNLKPEAMYTFRVVA-YNEWGPGESSQPIKVATQPELQV-PGPV-ENLQAVSTSPTSILITWE 549
            :|.:|||:..|.||::| |:.....||:...|...||...: |.|| |.|:....|.|::::.|.
  Fly   536 SVTDLKPQHTYRFRILAVYSNNDNKESNTSAKFYLQPGAALDPMPVPELLEIEEYSETAVVLHWS 600

Human   550 PPAYANGP-VQG-YRLFCTEVSTGKEQNIEVDGL---SYKLEGLKKFTEYSLRFLAYN------- 602
            ..:.|:.. :.| |..:....|.|:.....::|.   |:|:..|:..|.|..:..:::
  Fly   601 LASDADEHLITGYYAYYRPSSSAGEYFKATIEGAHARSFKIAPLETATMYEFKLQSFSAASASEF 665

Human   603 ---RYG----PGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNG------- 653
               :.|    |..||.:...:.:.|..:..|.       ::.:..:|  |..:||..|
  Fly   666 SALKQGRTQRPKTSTTEEPTLQMGDRDTTTPS-------HNETFNMS--PMLTGTIGGGAVLILL 721

Human   654 -FITGYKIRHRKTTR-RGEMETLEPN-----NLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWY 711
             ..|.:.:..|:.:| ||.    .||     .|...|..|...|....:.....::.|..|
  Fly   722 LISTCFCVCRRRNSRSRGN----NPNKPRMAELRDDFVPLGNCSPTKQRQRTRHIHITLNP---- 778

Human   712 TAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDS 776
            .|:..:..|:|....||.:..:.||.:    ..:.|.|.                      |:.|
  Fly   779 LAQQQQQALEEKNDTDQDAPYYQRPSS----YDYDPTLR----------------------RMSS 817

Human   777 ---KQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVP 838
               ::...::||...|:.        :|.|....|.:||...||.:|..|...........:...
  Fly   818 SSLRRSQRTLERAGGSNG--------SNNGNNNNLNQSAEAGSIENPGKPGRVLMKRPRLSSRSE 874

Human   839 DLSTPMLPPVGV 850
            :||:..|..|||
  Fly   875 NLSSGSLNSVGV 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCC	NP_005206.2	IgI_1_Neogenin_like	39..136	CDD:409387	26/110 (24%)
		Ig strand A	39..42	CDD:409387	0/1 (0%)
		Ig strand A'	45..51	CDD:409387	1/5 (20%)
		Ig strand B	55..65	CDD:409387	4/20 (20%)
		Ig strand C	70..76	CDD:409387	1/6 (17%)
		Ig strand C'	78..81	CDD:409387	1/2 (50%)
		Ig strand D	88..93	CDD:409387	0/4 (0%)
		Ig strand E	95..101	CDD:409387	1/5 (20%)
		Ig strand F	113..120	CDD:409387	3/6 (50%)
		Ig strand G	125..136	CDD:409387	3/12 (25%)
		Ig_3	139..216	CDD:464046	20/83 (24%)
		I-set	241..327	CDD:400151	25/99 (25%)
		Ig strand B	257..261	CDD:409562	1/3 (33%)
		Ig strand C	270..274	CDD:409562	0/3 (0%)
		Ig strand E	293..297	CDD:409562	1/3 (33%)
		Ig strand F	307..312	CDD:409562	2/4 (50%)
		Ig strand G	322..325	CDD:409562	0/2 (0%)
		Ig	334..417	CDD:472250	23/83 (28%)
		Ig strand B	348..352	CDD:409388	0/3 (0%)
		Ig strand C	361..365	CDD:409388	0/3 (0%)
		Ig strand E	383..387	CDD:409388	1/3 (33%)
		Ig strand F	397..402	CDD:409388	2/4 (50%)
		Ig strand G	410..413	CDD:409388	0/2 (0%)
		FN3	429..521	CDD:238020	27/104 (26%)
		FN3	<478..901	CDD:442628	89/423 (21%)
		FN3	946..1041	CDD:238020
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1152
		Neogenin_C	1148..1445	CDD:461954
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1165..1222
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1330
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1419
		Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953	1432..1439
ihog	NP_609085.1	Ig	266..348	CDD:472250	23/85 (27%)
		Ig strand B	278..282	CDD:409353	1/3 (33%)
		Ig strand C	291..295	CDD:409353	0/3 (0%)
		Ig strand E	313..317	CDD:409353	1/4 (25%)
		Ig strand F	327..332	CDD:409353	2/7 (29%)
		Ig strand G	341..344	CDD:409353	1/2 (50%)
		Ig	352..437	CDD:472250	24/86 (28%)
		Ig strand B	369..373	CDD:409353	0/3 (0%)
		Ig strand C	382..386	CDD:409353	0/3 (0%)
		Ig strand E	404..407	CDD:409353	0/2 (0%)
		Ig strand F	417..422	CDD:409353	2/4 (50%)
		Ig strand G	430..433	CDD:409353	0/2 (0%)
		FN3	467..565	CDD:238020	26/99 (26%)
		FN3	582..>655	CDD:238020	16/72 (22%)