DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DCC and Nrg

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:1301 Identity:277/1301 - (21%)
Similarity:450/1301 - (34%) Gaps:342/1301 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    49 AVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLSNG----SLLIQNILHSRHHK 109
            ::.:||..:.|.| ......:|...|.|||..:     :...:::.|    ||:|:     :.:.
  Fly   256 SLALRGKRMELFC-IYGGTPLPQTVWSKDGQRI-----QWSDRITQGHYGKSLVIR-----QTNF 309

Human   110 PDEGLYQCEASLG----DSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPT 170
            .|.|.|.|:.|.|    .|.|||.....|..     |..:.|..||...:.|:.:|...|.|.|.
  Fly   310 DDAGTYTCDVSNGVGNAQSFSIILNVNSVPY-----FTKEPEIATAAEDEEVVFECRAAGVPEPK 369

Human   171 IHWQKNQQDL---TPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILS 232
            |.|..|.:.:   ||.|  .|.|.  ...::|..|..||.|.|.|:|.| :......:..:.:.:
  Fly   370 ISWIHNGKPIEQSTPNP--RRTVT--DNTIRIINLVKGDTGNYGCNATN-SLGYVYKDVYLNVQA 429

Human   233 DPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLI 297
            :|..     ..:.|:.|..::|::..::|.|:|.|.|...|||...  .|...:|::....:|.|
  Fly   430 EPPT-----ISEAPAAVSTVDGRNVTIKCRVNGSPKPLVKWLRASN--WLTGGRYNVQANGDLEI 487

Human   298 SNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPV--P 360
            .:||..|:|.|||....|...|.|...|.|.........|.|..........|.|..:....  .
  Fly   488 QDVTFSDAGKYTCYAQNKFGEIQADGSLVVKEHTRITQEPQNYEVAAGQSATFRCNEAHDDTLEI 552

Human   361 TVNWMKNGDVVIPSDY-----FQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKP 420
            .::|.|:|..:   |:     |.....::|.|...::.|.|.|.|||......|...|.|||.. 
  Fly   553 EIDWWKDGQSI---DFEAQPRFVKTNDNSLTIAKTMELDSGEYTCVARTRLDEATARANLIVQD- 613

Human   421 AIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSRE------GDNRERALNT 479
                   :|:||: :..:...:....:.|....:.:..|..:|:.|:..      ....|:..||
  Fly   614 -------VPNAPK-LTGITCQADKAEIHWEQQGDNRSPILHYTIQFNTSFTPASWDAAYEKVPNT 670

Human   480 TQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPG-ESSQPIKVATQPELQVPGPVENLQAVSTSPTS 543
            .....:|::     |.|.|||||:|:|:.|.. .|:......|||::....| :|:....|.|.:
  Fly   671 DSSFVVQMS-----PWANYTFRVIAFNKIGASPPSAHSDSCTTQPDVPFKNP-DNVVGQGTEPNN 729

Human   544 ILITWEP-----------------------PAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKL 585
            ::|:|.|                       .|:.|..:..:|          :.||.:       
  Fly   730 LVISWTPMPEIEHNAPNFHYYVSWKRDIPAAAWENNNIFDWR----------QNNIVI------- 777

Human   586 EGLKKFTEYSLRFLAYNRYG-PGVSTDDITVVTLSDVPSAPPQNVSL-EVVNSRSIKVSWLPPPS 648
            .....|.:|.::.:|.|..| ..|:.:::...:..|.|...|.|.:: ::.:|.|..::|.|...
  Fly   778 ADQPTFVKYLIKVVAINDRGESNVAAEEVVGYSGEDRPLDAPTNFTMRQITSSTSGYMAWTPVSE 842

Human   649 GTQNGFITGYKIRHRKTTRRGEMETL-------EPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGP 706
            .:..|...||||: ..|...|| |.|       :.:|.  |.|..:..|:...::.|......||
  Fly   843 ESVRGHFKGYKIQ-TWTENEGE-EGLREIHVKGDTHNA--LVTQFKPDSKNYARILAYNGRFNGP 903

Human   707 PSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAE 770
            ||.....:|||.      ||.....|...| .::..::.|..||.||    |.:.||.:   |.|
  Fly   904 PSAVIDFDTPEG------VPSPVQGLDAYPLGSSAFMLHWKKPLYPN----GKLTGYKI---YYE 955

Human   771 TVR---VDSKQRY-----------YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPT 821
            .|:   |..::.|           ..:..|:.:|.|.||:.|....|||...|...||..     
  Fly   956 EVKESYVGERREYDPHITDPRVTRMKMAGLKPNSKYRISITATTKMGEGSEHYIEKTTLK----- 1015

Human   822 DPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWR 886
            |.|:..|       :.|..|...||.....|      ..|::|.. |...:..|....::.::..
  Fly  1016 DAVNVAP-------ATPSFSWEQLPSDNGLA------KFRINWLP-STEGHPGTHFFTMHRIKGE 1066

Human   887 TSFSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDL 951
            |.:....:.|:.|...:.    ||.|.|.|||.|:          |:..|..|     .||.:::
  Fly  1067 TQWIRENEEKNSDYQEVG----GLDPETAYEFRVV----------SVDGHFNT-----ESATQEI 1112

Human   952 TVITREGKPRAVIVSWQPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDT 1016
            ...|.||          |.:.||                       ||::               
  Fly  1113 DTNTVEG----------PIMVAN-----------------------ETVA--------------- 1129

Human  1017 MYYFRIQARNSKGVGPLSDPILFRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIG 1081
                                                      :.|::                ||
  Fly  1130 ------------------------------------------NAGWF----------------IG 1136

Human  1082 QMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQK 1146
            .|                        :....::::..:||..|               :.:|.:.
  Fly  1137 MM------------------------LALAFIIILFIIICIIR---------------RNRGGKY 1162

Human  1147 DLRPPDL----WIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSG 1207
            |:...:|    ..:.||.......:|.....|||.| :.|.......|.:.|..:.|...|:.:.
  Fly  1163 DVHDRELANGRRDYPEEGGFHEYSQPLDNKSAGRQS-VSSANKPGVESDTDSMAEYGDGDTAVAT 1226

Human  1208 QDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGY 1272
            .....|.::.|.| .||......:.:.......|...|...||..||.:..|. |...||.|...
  Fly  1227 AAARAAAAARSKL-TSLPTSTQQQQQQQQQQQQQQEQPQSTSASTVPLISLAS-PSPSPSSTSNS 1289

Human  1273 P 1273
            |
  Fly  1290 P 1290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 24/94 (26%)
Ig strand A 39..42 CDD:409387
Ig strand A' 45..51 CDD:409387 0/1 (0%)
Ig strand B 55..65 CDD:409387 2/9 (22%)
Ig strand C 70..76 CDD:409387 2/5 (40%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 0/4 (0%)
Ig strand E 95..101 CDD:409387 4/9 (44%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 4/10 (40%)
Ig_3 139..216 CDD:464046 25/79 (32%)
I-set 241..327 CDD:400151 26/85 (31%)
Ig strand B 257..261 CDD:409562 0/3 (0%)
Ig strand C 270..274 CDD:409562 0/3 (0%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 3/4 (75%)
Ig strand G 322..325 CDD:409562 0/2 (0%)
Ig 334..417 CDD:472250 20/89 (22%)
Ig strand B 348..352 CDD:409388 1/3 (33%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 429..521 CDD:238020 22/98 (22%)
FN3 <478..901 CDD:442628 109/470 (23%)
FN3 946..1041 CDD:238020 10/94 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152 2/25 (8%)
Neogenin_C 1148..1445 CDD:461954 30/130 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 13/56 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
NrgNP_001245581.1 Ig 29..128 CDD:472250
Ig strand B 55..59 CDD:409353
Ig strand C 68..72 CDD:409353
Ig strand E 94..98 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 137..216 CDD:472250
Ig strand B 151..155 CDD:409353
Ig strand C 165..169 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 209..214 CDD:409353
ig 251..332 CDD:395002 21/86 (24%)
Ig strand B 264..268 CDD:409353 1/3 (33%)
Ig strand C 277..281 CDD:409353 0/3 (0%)
Ig strand E 305..309 CDD:409353 0/8 (0%)
Ig strand F 314..319 CDD:409353 2/4 (50%)
Ig strand G 328..331 CDD:409353 1/2 (50%)
IgI_4_hemolin-like 339..427 CDD:409570 26/97 (27%)
Ig strand A 339..342 CDD:409570 0/7 (0%)
Ig strand A' 348..351 CDD:409570 1/2 (50%)
Ig strand B 356..363 CDD:409570 2/6 (33%)
Ig strand C 369..374 CDD:409570 2/4 (50%)
Ig strand C' 377..379 CDD:409570 0/1 (0%)
Ig strand D 387..391 CDD:409570 1/3 (33%)
Ig strand E 393..397 CDD:409570 0/3 (0%)
Ig strand F 406..414 CDD:409570 4/7 (57%)
Ig strand G 417..427 CDD:409570 0/9 (0%)
Ig 446..517 CDD:472250 24/72 (33%)
Ig strand B 449..453 CDD:409358 0/3 (0%)
Ig strand C 462..466 CDD:409358 0/3 (0%)
Ig strand E 483..487 CDD:409358 1/3 (33%)
Ig strand F 497..502 CDD:409358 3/4 (75%)
Ig strand G 510..513 CDD:409358 1/2 (50%)
Ig 521..615 CDD:472250 22/104 (21%)
Ig strand B 538..542 CDD:409353 1/3 (33%)
Ig strand C 553..557 CDD:409353 0/3 (0%)
Ig strand E 577..581 CDD:409353 1/3 (33%)
Ig strand F 591..596 CDD:409353 2/4 (50%)
Ig strand G 604..607 CDD:409353 0/2 (0%)
FN3 613..707 CDD:238020 22/107 (21%)
FN3 683..>1051 CDD:442628 100/421 (24%)
fn3 817..905 CDD:394996 23/91 (25%)
fn3 918..1007 CDD:394996 24/95 (25%)
FN3 1041..1111 CDD:238020 20/89 (22%)
Bravo_FIGEY 1155..>1221 CDD:464016 15/81 (19%)
Blue background indicates that the domain is not in the aligned region.

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