DRSC/TRiP Functional Genomics Resources

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Protein Alignment DCC and boi

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_001096868.3 Gene:boi / 31229 FlyBaseID:FBgn0040388 Length:1105 Species:Drosophila melanogaster


Alignment Length:1394 Identity:276/1394 - (19%)
Similarity:445/1394 - (31%) Gaps:489/1394 - (35%)


- Green bases have known domain annotations that are detailed below.


Human    16 VLFGASLFSAHLQVTGFQIKAFTALRFLSE--PSDAVTMRGGNVLLDC--SAESDRGVPVIKWK- 75
            ||....:::  ||.:.......|.|..|.|  |..||..:|..|:.:|  :.:.||    ::|: 
  Fly    12 VLMTTCIYT--LQASDSNSSVATTLGVLFERAPESAVAPKGDEVVFECELNLKPDR----LEWRF 70

Human    76 --------------KDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGS 126
                          ..|.::..|.|....:|        .|..|.....|   |||.|..| .|:
  Fly    71 RRGDSSEPYLYLRPSAGYNVTSGSDGLAWRL--------RIYVSAQTAGD---YQCVAWYG-PGA 123

Human   127 IISRTAKVAVAGPLRFLSQTESVTAFMG------------DTVLLKC-EVIGEPMPTIHWQKNQQ 178
            :.|..|::|:......:.|     ..||            :.:|::| .||..|.....:.:|.:
  Fly   124 LASTPARLALVSIALDVGQ-----GSMGARSSIRWSVAPKNCLLIRCGSVISNPPAIWSFYRNGK 183

Human   179 DLTP---IPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNE------AEVRILSDP 234
            .|..   :||       .:|||.:..:...|.|.|.|.|.|   |.||:|      .|:|:  |.
  Fly   184 KLPQSELLPG-------AAGALVLDTVTAKDAGNYSCVATN---SITGDELRLPQTIELRV--DY 236

Human   235 GLHRQLYFLQRPS-NVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLIS 298
            ......||||||. ...|..|:..||||...|.|.|...| ....|:::.:.:.::| ...|.|:
  Fly   237 TDRTPPYFLQRPPIEYSARPGETVVLECPGVGSPRPRVIW-SSPNVVEIYNNRSTIL-SYGLQIT 299

Human   299 NVTDDDSGMYTCVVTYKNEN-----ISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKP 358
            :|..:|.|.|.|::    :|     |..:.:|:||..|..|..|:.....||..:..:|:.||.|
  Fly   300 DVKPEDQGSYICML----DNGIAPPIDHTIKLSVLQRPTILRGPAATLTNESNPLLLDCSASGNP 360

Human   359 VPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
            .|.:.|:.||:.. ..|...:|...:|::..|.|...|..||.|:|..|  :||           
  Fly   361 QPDIYWLINGEDA-TKDPEAVVDNRSLQLKRVQKRHAGVVQCFAKNILG--ETS----------- 411

Human   424 SSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLT 488
                                            :|||                    .:...|::|
  Fly   412 --------------------------------EGNI--------------------LRVNPLEIT 424

Human   489 VGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVP-GPV-ENLQAVSTSPTSILITWEPP 551
                                  ||..:|:.       :|| .|| |:...:.||.||        
  Fly   425 ----------------------GEDDEPLG-------EVPVWPVHESNTGMGTSSTS-------- 452

Human   552 AYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVV 616
                                        |.|....|.:||                         
  Fly   453 ----------------------------GGSKNKSGRRKF------------------------- 464

Human   617 TLSDVPSAPPQNVSLEVVNSRSIKVSW-LPPPSGTQNGFITGYKIRHR-----KTTRRGEMETLE 675
               .....||...::..::..|:.:.| :|..||.|   ||.:|:::|     |..|:....|.:
  Fly   465 ---KASMVPPSRPNVTRLSDESVMLRWSVPQNSGLQ---ITFFKVQYRMLGDGKNRRKNWQTTSD 523

Human   676 ---------------------------------PNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
                                             |.|.....|||..|..|.|::.|:..|.....
  Fly   524 NIPYGNAHGSGPGQGNSHWRARNRDREYEMGNPPKNFTSSVTGLTAGKYYRFRIVAVYSNNDNKE 588

Human   708 SNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWT-PPLNPNIVVRGYIIGYGVGSPYAE 770
            .|.......:|...:|.:| .|....|.. ..:.:::.|: .....|..:.||...|......||
  Fly   589 GNTSLKFFLQNGTSKSNLP-VPELREVETLSESAVVLHWSLVSSTQNEDIDGYYAYYRPADSAAE 652

Human   771 TVR--VD-SKQRYYSIERLESSSHYVISLKAFNN--AGEGVPLYESATTRSITDPTD----PVDY 826
            .::  || ...|.:.|:.|...:.|...|::||:  |.|...:.::.|.::...|..    ||..
  Fly   653 YLKATVDGGMSRSFKIDLLRPGTPYEFKLQSFNSDAASEFSAIRQARTRKTHEQPASSSATPVPA 717

Human   827 YPLLDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWA----DNSVPKNQKTSEVRLYTVRWRT 887
            ...::....|:    .|::.......:.|...::.|...    :||.|:::...::......:.|
  Fly   718 NKAVEQHQNSL----YPLIAGAAGGGILLLIASLVVCLCLKRRENSQPEDENKPQLEHIQADFVT 778

Human   888 S--FSASAKYKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKD 950
            |  ......:||.|...|:    |:.|             |.:.|                 |..
  Fly   779 SAVLGVGGHHKSGDVRRLN----GVIP-------------RMNIT-----------------PNP 809

Human   951 LTVITREGKPRAVI-VSWQPPLEANGKITAYILFYTL------------------DKNIP-IDDW 995
            |...|...|.|.|: :.:.||| |||......:...|                  :|.:| :...
  Fly   810 LAQETASDKNRNVMELRFLPPL-ANGNGNGNCMARDLALERSNAEEQQDEDGHEDEKGLPAVASS 873

Human   996 IMETISGDRLTHQIMDLNLDTMY-YFRIQARN------SKGVGPLSDPILFRTLKVEHPDKMAND 1053
            ..||:..   ....:.|||...: ..::.|.|      ||.:.||             |.|.||.
  Fly   874 SCETLEA---CDAAIKLNLPQKHDQEQLDAPNAVLEAPSKPLPPL-------------PKKPANG 922

Human  1054 QGRHGDG----------GYWPVDTNLIDRSTLN----EPPI------------------------ 1080
            .|::..|          .|.|..|..:....|:    .||:                        
  Fly   923 AGQNNSGLHQNGLHHAQPYHPPGTPTLMHKRLDYHQQPPPVPPHSAYYQQAPTHQPSPMMERSVR 987

Human  1081 -----GQMHPPHGSVTPQKNSNLLVIIVVTVGVITVLVVVIVAVICTRRSSAQQRKKRATHS--- 1137
                 |..|...|:.||.:                     |.::...||:|..|:... :||   
  Fly   988 GHQQPGGFHMEEGTPTPTR---------------------IPSLRRQRRTSGNQQVHN-SHSNLN 1030

Human  1138 --AGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSGT--------DPAGRDSPIQSCQDLTPVSHS 1192
              ......:..:|.|....:||..      ..|.|.        .|..:.||:       |....
  Fly  1031 IGLSHHNNNNNNLPPHHQHLHHHP------GHPGGLVGIPIVPGSPRVQRSPM-------PSRAM 1082

Human  1193 QSETQLGSKSTSHSGQDTEEAGSSMSTLE 1221
            ...|:|||.:.:.|       ..|::::|
  Fly  1083 IKRTRLGSHTDNIS-------SGSLNSIE 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 27/115 (23%)
Ig strand A 39..42 CDD:409387 1/2 (50%)
Ig strand A' 45..51 CDD:409387 3/7 (43%)
Ig strand B 55..65 CDD:409387 2/11 (18%)
Ig strand C 70..76 CDD:409387 1/20 (5%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 0/4 (0%)
Ig strand E 95..101 CDD:409387 0/5 (0%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 3/10 (30%)
Ig_3 139..216 CDD:464046 20/92 (22%)
I-set 241..327 CDD:400151 28/91 (31%)
Ig strand B 257..261 CDD:409562 2/3 (67%)
Ig strand C 270..274 CDD:409562 0/3 (0%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 2/4 (50%)
Ig strand G 322..325 CDD:409562 0/2 (0%)
Ig 334..417 CDD:472250 25/82 (30%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 1/2 (50%)
FN3 429..521 CDD:238020 8/91 (9%)
FN3 <478..901 CDD:442628 84/480 (18%)
FN3 946..1041 CDD:238020 26/121 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152 6/30 (20%)
Neogenin_C 1148..1445 CDD:461954 17/82 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 13/65 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
boiNP_001096868.3 IG_like 42..131 CDD:214653 24/104 (23%)
Ig 161..221 CDD:409353 19/69 (28%)
Ig strand B 161..165 CDD:409353 1/3 (33%)
Ig strand C 175..179 CDD:409353 0/3 (0%)
Ig strand E 196..200 CDD:409353 3/3 (100%)
Ig strand F 210..215 CDD:409353 2/4 (50%)
Ig 242..315 CDD:472250 25/78 (32%)
Ig strand B 260..264 CDD:409353 2/3 (67%)
Ig strand C 273..277 CDD:409353 1/4 (25%)
Ig strand E 294..298 CDD:409353 1/3 (33%)
Ig strand F 308..313 CDD:409353 2/4 (50%)
Ig <352..408 CDD:472250 18/56 (32%)
Ig strand C 363..367 CDD:409353 0/3 (0%)
Ig strand E 384..388 CDD:409353 1/3 (33%)
Ig strand F 398..403 CDD:409353 2/4 (50%)
FN3 <448..>700 CDD:442628 58/319 (18%)
FN3 613..700 CDD:238020 19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

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