DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DCC and sdk

DIOPT Version :10

Sequence 1:NP_005206.2 Gene:DCC / 1630 HGNCID:2701 Length:1447 Species:Homo sapiens
Sequence 2:NP_001284756.1 Gene:sdk / 31017 FlyBaseID:FBgn0021764 Length:2265 Species:Drosophila melanogaster


Alignment Length:1651 Identity:394/1651 - (23%)
Similarity:604/1651 - (36%) Gaps:431/1651 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    26 HLQVTG---FQIKAFTALRFLSEPSDA-VTMRGGNVLLDCSAESDRGVPVIK--WKKDGIHLALG 84
            ||.|:|   .::    |...:..|.|. |.:..|.|.|.|.|.: |.:..::  |.|||  ||:.
  Fly   248 HLNVSGDPYIEV----APEIIVRPQDVKVKVGTGVVELQCIANA-RPLHELETLWLKDG--LAVE 305

Human    85 MDERKQQLSNG-----SLLIQNILHSRHHKPDEGLYQCEASLGDSG-SIISRTAKVAVAGPLRFL 143
            ....:..|::.     :||..|..||       |.|.|:..|...| ..:|.:|::.:..|..|.
  Fly   306 TAGVRHTLNDPWNRTLALLQANSSHS-------GEYTCQVRLRSGGYPAVSASARLQILEPPLFF 363

Human   144 SQTESVT-AFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDI 207
            :...:.| ...|..|.|.|:|:|||.|.:.|.:|.:.:.......|..:.....|.|.:|...|.
  Fly   364 TPMRAETFGEFGGQVQLTCDVVGEPTPQVKWFRNAESVDAHIESGRYTLNTDNTLVIKKLILDDA 428

Human   208 GIYRCSARN----------------PASSRTGNEAEVRIL----SDPGL-------------HRQ 239
            .:::|.|.|                .|.:|....|:.|||    |..||             .::
  Fly   429 AMFQCLAINEAGENSASTWLRVKTKTAKNRVKRLAQPRILRVRASHAGLGSEKGSESGSSDRRKE 493

Human   240 LYFLQR------PSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLIS 298
            ..|...      |.||.|::||||.:.|...|.|.|:.||:..|..:...|.:..:|...:||||
  Fly   494 FRFASAPIMELPPQNVTALDGKDATISCRAVGSPNPNITWIYNETQLVDISSRVQILESGDLLIS 558

Human   299 NVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKP-VP-T 361
            |:...|:|:|.||...:..::...|.|:|||....:..|.:......:....:|.||..| || .
  Fly   559 NIRSVDAGLYICVRANEAGSVKGEAYLSVLVRTQIIQPPVDTTVLLGLTATLQCKVSSDPSVPYN 623

Human   362 VNWMKNGDVVIPSDYFQIVG---GSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP 423
            ::|.:.|....|....|.:|   ...|.|..|..||.|.|.||..:..||...:|:|.|.:...|
  Fly   624 IDWYREGQSSTPISNSQRIGVQADGQLEIQAVRASDVGSYACVVTSPGGNETRAARLSVIELPFP 688

Human   424 SSSV----LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTV---FFSREGDNRERALN-TT 480
            .|:|    ||..         ..|.:.:||.|..:....|..|.:   ..|..|...:..|| .|
  Fly   689 PSNVKVERLPEP---------QQRSINVSWTPGFDGNSPISKFIIQRREVSELGPVPDPLLNWIT 744

Human   481 QPGSLQ-----LTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGPVENLQAVSTS 540
            :..::.     :.:.|||...:|.|||.|.|..|.|..|:|..|...|:....||.......:.|
  Fly   745 ELSNVSADQRWILLENLKAATVYQFRVSAVNRVGEGSPSEPSNVVELPQEAPSGPPVGFVGSARS 809

Human   541 PTSILITWEPP--AYANGPVQG----YRLFCTEVSTGKEQNIEVDG-LSYKLEGLKKFTEYSLRF 598
            .:.|:..|:||  .:.||.:.|    ||||.........|||..:. .::.::.|..:.:|.::.
  Fly   810 MSEIITQWQPPLEEHRNGQILGYILRYRLFGYNNVPWSYQNITNEAQRNFLIQELITWKDYIVQI 874

Human   599 LAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITGYKIR-- 661
            .|||..|.||.|:...:.|...||.|||.||.:|.:||.:.:..|.||.....||...||||:  
  Fly   875 AAYNNMGVGVYTEGSKIKTKEGVPEAPPTNVKVEAINSTAARCRWTPPNPQQINGINQGYKIQAW 939

Human   662 --------HRKTTRRGEMETLEPNNL------WYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYT 712
                    .|...||  |:|:.|:.:      ..:..||||.::|:..|...|..|.|..|:...
  Fly   940 QRRLIDGEWRDIERR--MKTVPPSLIDPLAEQTAILGGLEKFTEYNISVLCFTDPGDGVASSQVA 1002

Human   713 AETPENDLDESQVPDQPSSLHVRPQTN-CIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDS 776
            ..|.::      |||:.:.||....:: .:.:.|.||...|.::.||.:.|.|..      |.|:
  Fly  1003 VMTMDD------VPDEVTGLHFDDVSDRSVKVLWAPPRASNGILTGYTVRYQVKD------RPDT 1055

Human   777 KQRY--------YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDP---------- 823
            .:.:        .::.:|::::||...:.|:...|.|:|  ::||.:|..:|..|          
  Fly  1056 LKSFNLTADDTELTVNQLQATTHYWFEIVAWTRVGSGIP--KTATIQSGVEPVLPHAPTALALSN 1118

Human   824 VDYYPLLDDFP------TSV-----------------------PDLST----------------- 842
            ::.:.::..|.      :|:                       ||..|                 
  Fly  1119 IEAFSVVLQFTPGFDGNSSITKWKVEGQTARNMTWFTICEINDPDAETLTVTGLVPFTQYRLRLS 1183

Human   843 -----------------------PMLPPVGVQAVALTHDAVRVSWADNSVPKNQKT--SEVRLYT 882
                                   |..||..|...|::...:||.|    :|..|..  ...|.|.
  Fly  1184 ASNVVGSSKPSEATKDFQTIQARPKHPPFNVTVRAMSAQQLRVRW----IPLQQTEWYGNPRGYN 1244

Human   883 VRWR--TSFSASAKYKS-----EDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTY 940
            :.::  .....:.||..     ||.|:.|:....|:..|:||..:....:...|..|.||...|.
  Fly  1245 ISYKQLVKTPGTIKYVPRSVVIEDHTANSHVLDSLEEWTLYEVKMNACNDVGCSKESDTAVERTR 1309

Human   941 EAAPTSAPKDLTVITREGKPRAVIVSW--QPPLEANGKITAYILFY--------TLDKNIPIDDW 995
            ||.|:..|.|  |.........|:|.|  .|....||:|..|.:||        .|.|.||    
  Fly  1310 EAVPSYGPLD--VQANATSSTTVVVQWGEVPRQHRNGQIDGYKVFYAAADRGQQVLHKTIP---- 1368

Human   996 IMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLS-DPILFRTLK--------VEHPD--- 1048
                 :....|..:.:|....:|:.::.|....|.|.|| .||..:|.:        |..||   
  Fly  1369 -----NNATFTTTLTELKKYVVYHVQVLAYTRLGNGALSTPPIRVQTFEDTPGVPSNVSFPDVSL 1428

Human  1049 KMANDQGRHGDGGYW--PVDTN-----------LIDRSTLNEPPIGQMHPPHG------SVTPQK 1094
            .||..        .|  |||.|           |...:.||   ..:..||..      .:.|.|
  Fly  1429 TMARI--------IWDVPVDPNGKILAYQVTYTLNGSAMLN---YSREFPPSDRTFRATELLPGK 1482

Human  1095 NSNLLVIIVVTVG---VITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQ----------- 1145
            ..:........:|   :.|.||.           :...|::....|..:...||           
  Fly  1483 YYSFSCTAQTRLGWGKIATALVY-----------TTNNRERPQAPSVPQISRSQIQAHQITFSWT 1536

Human  1146 --KDLRPPDLWIHHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSK---STSH 1205
              :|...|   :.:..:||:..|        ||..|:....|    ....|.|.:|.:   :...
  Fly  1537 PGRDGFAP---LRYYTVEMRENE--------GRWQPLPERVD----PSLSSFTAVGLRPYMTYQF 1586

Human  1206 SGQDTEEAGSSMSTLERSLAARRAPRAKLMIPMDAQSNNPAV----VSAIPVPT---------LE 1257
            ..|.|.:.|.|..:.| |:..|..|.|            |||    :..:|:.|         ||
  Fly  1587 RIQATNDLGPSAFSRE-SVIVRTLPAA------------PAVGVGGLKVVPITTTSVRVQWSALE 1638

Human  1258 SAQYPGILPSPTCGYP--HPQFTLRPVPFPT----------------------LSVDRGFGAGRS 1298
            :|.:.|  .:.|.||.  :.|.:    .|||                      |..||.:.....
  Fly  1639 TALWNG--DASTGGYRILYQQLS----DFPTALQSTPKTDVHGINENSVVLSDLQQDRNYEIVVL 1697

Human  1299 QSVSEGPTTQQPP-------MLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLL--PPPM 1354
            ...|:||....||       .:|..:|          |.:..|      |:.|....||  ||..
  Fly  1698 PFNSQGPGPATPPAAVYVGEAVPTGEP----------RAVDAA------PISSTEVRLLWKPPKQ 1746

Human  1355 S---------AIEPKVPYTPLLSQPG 1371
            |         .|...|.|:|...:||
  Fly  1747 SMQNGDILGYKIYYLVTYSPQALEPG 1772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DCCNP_005206.2 IgI_1_Neogenin_like 39..136 CDD:409387 29/105 (28%)
Ig strand A 39..42 CDD:409387 1/2 (50%)
Ig strand A' 45..51 CDD:409387 2/6 (33%)
Ig strand B 55..65 CDD:409387 5/9 (56%)
Ig strand C 70..76 CDD:409387 1/7 (14%)
Ig strand C' 78..81 CDD:409387 1/2 (50%)
Ig strand D 88..93 CDD:409387 0/4 (0%)
Ig strand E 95..101 CDD:409387 2/10 (20%)
Ig strand F 113..120 CDD:409387 3/6 (50%)
Ig strand G 125..136 CDD:409387 3/11 (27%)
Ig_3 139..216 CDD:464046 21/77 (27%)
I-set 241..327 CDD:400151 30/91 (33%)
Ig strand B 257..261 CDD:409562 1/3 (33%)
Ig strand C 270..274 CDD:409562 1/3 (33%)
Ig strand E 293..297 CDD:409562 1/3 (33%)
Ig strand F 307..312 CDD:409562 2/4 (50%)
Ig strand G 322..325 CDD:409562 1/2 (50%)
Ig 334..417 CDD:472250 25/87 (29%)
Ig strand B 348..352 CDD:409388 0/3 (0%)
Ig strand C 361..365 CDD:409388 0/3 (0%)
Ig strand E 383..387 CDD:409388 1/3 (33%)
Ig strand F 397..402 CDD:409388 2/4 (50%)
Ig strand G 410..413 CDD:409388 0/2 (0%)
FN3 429..521 CDD:238020 26/100 (26%)
FN3 <478..901 CDD:442628 128/548 (23%)
FN3 946..1041 CDD:238020 27/105 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1152 5/38 (13%)
Neogenin_C 1148..1445 CDD:461954 61/282 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1165..1222 12/59 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1288..1330 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419
Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953 1432..1439
sdkNP_001284756.1 Ig_3 72..142 CDD:464046
Ig 280..344 CDD:409353 20/73 (27%)
Ig strand B 280..283 CDD:409353 1/2 (50%)
Ig strand C 292..298 CDD:409353 0/5 (0%)
Ig strand E 319..323 CDD:409353 0/3 (0%)
Ig strand F 333..338 CDD:409353 2/4 (50%)
Ig 360..451 CDD:472250 21/90 (23%)
Ig strand B 378..382 CDD:409353 2/3 (67%)
Ig strand C 391..395 CDD:409353 0/3 (0%)
Ig strand E 416..420 CDD:409353 1/3 (33%)
Ig strand F 430..435 CDD:409353 1/4 (25%)
Ig strand G 443..446 CDD:409353 0/2 (0%)
Ig 502..587 CDD:472250 29/84 (35%)
Ig strand B 517..521 CDD:409353 1/3 (33%)
Ig strand C 530..534 CDD:409353 1/3 (33%)
Ig strand E 554..557 CDD:409353 1/2 (50%)
Ig strand F 567..572 CDD:409353 2/4 (50%)
Ig strand G 580..583 CDD:409353 0/2 (0%)
Ig 592..682 CDD:472250 25/89 (28%)
Ig strand B 608..612 CDD:409353 0/3 (0%)
Ig strand C 623..627 CDD:409353 0/3 (0%)
Ig strand E 648..652 CDD:409353 1/3 (33%)
Ig strand F 662..667 CDD:409353 2/4 (50%)
Ig strand G 675..678 CDD:409353 0/2 (0%)
FN3 686..789 CDD:238020 29/111 (26%)
FN3 798..893 CDD:238020 26/94 (28%)
FN3 901..1005 CDD:238020 32/105 (30%)
FN3 <960..>1261 CDD:442628 58/318 (18%)
fn3 1317..1402 CDD:394996 23/95 (24%)
FN3 1415..1507 CDD:238020 21/113 (19%)
FN3 1513..1608 CDD:238020 21/110 (19%)
FN3 1583..>2011 CDD:442628 50/225 (22%)
Blue background indicates that the domain is not in the aligned region.

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