DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCC and unc-40

DIOPT Version :9

Sequence 1:	NP_005206.2	Gene:	DCC / 1630	HGNCID:	2701	Length:	1447	Species:	Homo sapiens
Sequence 2:	NP_491664.1	Gene:	unc-40 / 172233	WormBaseID:	WBGene00006776	Length:	1415	Species:	Caenorhabditis elegans

Alignment Length:	1451	Identity:	442/1451 - (30%)
Similarity:	681/1451 - (46%)	Gaps:	222/1451 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    31 GFQIKAFTALRFLSEPSDAVT-MRGGNVLLDCS--AESDRGV--PVIKWKKDGIHLALGMDERKQ 90
            |||        |:.||...|| |...:.||:||  ...:|.|  ..|:||:||:.|:.....|.:
Worm    40 GFQ--------FVMEPRRNVTVMESSSHLLECSYVLAHERLVHDVRIEWKRDGVLLSERTSSRIK 96

Human    91 QLSNGSLLIQNILHSRHHKPDEGLYQCEASL-------GDSGSIISRTAKVAVAGPLRFLSQTES 148
            .:|||||.|:::     ...:||.|||...:       .|:.:.:||.|.:.:|...:|..|...
Worm    97 VMSNGSLWIESV-----SSAEEGTYQCAVHVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAID 156

Human   149 VTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLP-SGALQISRLQPGDIGIYRC 212
            .|...|......|.:..:|.||..|..|.:   ||.......:|| |..|:||..|....|.|||
Worm   157 RTLAKGQPTAFHCLINSKPTPTAVWLHNDE---PIVNGGEYHILPVSNTLEISSTQSRHEGTYRC 218

Human   213 SARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGE 277
            :.......|:...|.:.:.::. :..:|.|:..|...|..:|.:.:|||.|:....|...||:..
Worm   219 TVEGAGKRRSSQTARLTVTTET-VSNELVFITTPRLQVVEQGDEFLLECLVASLIRPQVRWLKDS 282

Human   278 EVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYA 342
            ..|.:...:...:|.|::|:|..:.:|:|:|||..:..:::|..:..:.|..||.....|:...|
Worm   283 RQIIVDGVRIRRVGVSSILVSRASIEDTGLYTCRASNNDDSIDRAVSVEVRAPPRITTRPTTKVA 347

Human   343 YESMDIEFEC-TVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEA 406
            .|:.|:|.|| |.:.:|...|||.|||:.:|.|:|| ::..:.|||||||::|:..|||:|||:.
Worm   348 VETADVELECGTAAARPEARVNWYKNGEAIIGSEYF-VIEPNRLRILGVVRADQAIYQCIAENDV 411

Human   407 GNAQTSAQLIVPKP---AIPSSSVLP---SAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVF 465
            |:.|.||||:|..|   ::.:||.:|   |||..:......|||:.:.|.||.:..|||..:.:|
Worm   412 GSEQASAQLLVDAPDSSSVAASSGVPMTSSAPLGLRSTSSGSRFINVEWDPPVQRNGNIMRYHIF 476

Human   466 FSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPELQVPGP 530
            :.....:|||.:|::   |...|:.:|:|..||..||.|.||.|.|:.|..:||.|..|..|||.
Worm   477 YKDNLIDRERMINSS---STSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKVTTNKEQAVPGK 538

Human   531 VENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTE---VSTGKEQNIEVDGLSYKLEGLKKFT 592
            |.:|...:|.|.:|.|.|.||: ...|...|::|.:.   ....||..|......|.|.|:.|:|
Worm   539 VASLTTTATGPETIDIRWSPPS-GGQPALRYKIFYSHDPLEKNEKETLITTSTTHYTLHGMDKYT 602

Human   593 EYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFITG 657
            .|.:|..|....|.|:|:|.:.|.|.||.|||||.|:..|..:|.|::|||..|...:.||.|||
Worm   603 GYQIRIEAEGSNGSGLSSDTVKVRTQSDEPSAPPVNIQAEADSSTSVRVSWDEPEEESVNGEITG 667

Human   658 YKIRHRKTTR--RGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720
            |:::::...|  :|....::.....|....||..:||..:::.:..|||||.|:|.:.:||..|.
Worm   668 YRLKYKTKARGAKGNTLVIDATAREYTMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQDK 732

Human   721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIER 785
            :|..: ..|..:......:.|::||.||.:...:||||.||:|:..|..||:||.:....|.|.|
Worm   733 EERTL-GAPREIRPHAGIDYILVSWLPPADEQNLVRGYQIGWGLSVPDTETIRVTASTTQYKIAR 796

Human   786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGV 850
            |.|...|||||:||||.|.|.|:||:..|.|...|:.      ..:|..:...|:.:....||||
Worm   797 LHSERDYVISLRAFNNLGSGFPIYETVRTLSRETPSH------FNEDSDSDDSDVGSSESTPVGV 855

Human   851 QAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTM 915
            :|.|::..::||.|.:     :.:|:....||||:.|:...: :::..::|....|..||:|.|.
Worm   856 RAEAISATSIRVMWTE-----SDETAFNTQYTVRYSTAVDGN-QHRYVNSTETWATVEGLRPATE 914

Human   916 YEFSV-MVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITRE-GKPRAVIVSWQPPLEANGKIT 978
            |||:| .|..|.:.|||||.....|..|.|:|||:||||:..| |.|.:..:.||||..:||:|.
Worm   915 YEFAVRAVASNGQLSTWSMATRNRTLAAPPSSAPRDLTVLPAESGDPHSSSLHWQPPKYSNGEIE 979

Human   979 AYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFRTLK 1043
            .|::|||...::...||.:..::||:|:||:.:|.....|:|:|||||.||.||.|..:.:
Worm   980 EYLVFYTDRASLADKDWTINYVAGDKLSHQVSNLLPKANYFFKIQARNEKGHGPFSSVVGY---- 1040

Human  1044 VEHPDKMANDQGRH---GDGGYWPVDT-NLID--RSTLNEPPIGQMHPPHGSVTPQKNSNLLVII 1102
            ......:.:.:.||   |.|.....|| :|:|  :|.|:..|                  |.:|:
Worm  1041 TPSGGAILSGKDRHNARGHGSAASGDTVSLVDQLQSLLHSNP------------------LYLIL 1087

Human  1103 VVTVGVITVLVVVIVAVICTRRSSAQQRK------KRATHSAGKRKGSQKDLRPP-DLWIHHEEM 1160
            :....:|.:|.::::.:.|.:|||...||      |:.:..||...|......|| ||||:....
Worm  1088 LAAFALILILTLILIIMCCWKRSSGGGRKNGYQSGKKTSAGAGSGGGIGGLGGPPNDLWINGTGS 1152

Human  1161 EMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSH-SGQDTEEAG------SSMS 1218
            .|:          ||                 .|:..:...:|:| :..|.|...      ....
Worm  1153 HMR----------AG-----------------ASDYMVDGLATAHLTAADIESPTPRYHHLQGQG 1190

Human  1219 TLERSLAARRAPRAKLMIPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVP 1283
            ||.||.  .::.::     ::.:...|.||            |.|              |.|..|
Worm  1191 TLTRSY--HQSSQS-----LEGRQRTPQVV------------YTG--------------TGRHQP 1222

Human  1284 FPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTA-----CVRPTHPLR 1343
            ...:..:..:|:  |.::....|...|...|||.|             ||.     .:|.|.|..
Worm  1223 IQRIDFESPYGS--SSAIGSASTPPLPMQAPPSGP-------------PTVIDGYRTLRGTPPNS 1272

Human  1344 SFANPL---------LPPPMSAIEPKVPYTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSV 1399
            |.||.|         .|||        |::...|...||:           :|...|.  :||..
Worm  1273 SAANALRSFTQLAGATPPP--------PHSAASSSSRPTI-----------IAAGGRQ--VPVGR 1316

Human  1400 PTAPEVSEESHKPTEDSANVY 1420
            .||        :|..:.||:|
Worm  1317 ATA--------QPRVNVANIY 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCC	NP_005206.2	Ig1_Neogenin	41..136	CDD:143199	34/106 (32%)
		IG_like	46..136	CDD:214653	32/101 (32%)
		IG_like	147..224	CDD:214653	22/77 (29%)
		IGc2	153..219	CDD:197706	20/66 (30%)
		I-set	241..327	CDD:254352	22/85 (26%)
		Ig	244..327	CDD:299845	21/82 (26%)
		I-set	331..417	CDD:254352	40/86 (47%)
		Ig	347..417	CDD:299845	36/70 (51%)
		FN3	429..521	CDD:238020	34/94 (36%)
		FN3	528..617	CDD:238020	30/91 (33%)
		FN3	625..715	CDD:238020	30/91 (33%)
		FN3	726..805	CDD:214495	33/78 (42%)
		FN3	846..939	CDD:238020	32/93 (34%)
		FN3	946..1041	CDD:238020	41/95 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1152		9/32 (28%)
		Neogenin_C	1148..1445	CDD:284094	60/295 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1165..1222		9/63 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419		6/24 (25%)
		Interaction with MYO10. /evidence=ECO:0000269\|PubMed:21642953	1432..1439
unc-40	NP_491664.1	I-set	42..130	CDD:254352	31/100 (31%)
		Ig	43..142	CDD:299845	34/103 (33%)
		I-set	149..236	CDD:254352	25/89 (28%)
		Ig	158..237	CDD:299845	23/81 (28%)
		IG_like	251..332	CDD:214653	21/80 (26%)
		IGc2	258..320	CDD:197706	18/61 (30%)
		I-set	336..422	CDD:254352	40/86 (47%)
		Ig	352..422	CDD:299845	36/70 (51%)
		FN3	441..529	CDD:238020	33/90 (37%)
		FN3	536..627	CDD:238020	30/91 (33%)
		FN3	635..727	CDD:238020	30/91 (33%)
		FN3	738..816	CDD:214495	33/77 (43%)
		FN3	852..927	CDD:214495	27/80 (34%)
		FN3	946..1038	CDD:238020	41/91 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	87	1.000	Domainoid score	I5594
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21081
Inparanoid	1	1.050	594	1.000	Inparanoid score	I579
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46607
OrthoDB	1	1.010	-	-		D118438at33208
OrthoFinder	1	1.000	-	-		FOG0002773
OrthoInspector	1	1.000	-	-		otm15629
orthoMCL	1	0.900	-	-		OOG6_105369
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3265
SonicParanoid	1	1.000	-	-		X1863
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.910