Protein Alignment DCC and Dcc

DIOPT Version :10

• Sequence 1: NP_005206.2
• Gene: DCC / 1630
• HGNCID: 2701
• Length: 1447
• Species: Homo sapiens
• Sequence 2: NP_031857.2
• Gene: Dcc / 13176
• MGIID: 94869
• Length: 1447
• Species: Mus musculus
• Alignment Length: 1447
• Identity: 1396/1447 - (96%)
• Similarity: 1423/1447 - (98%)
• Gaps: 0/1447 - (0%)

Human     1 MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAES 65
            |||||.||||||||||||||||.||||||||||||.||:|.|:||||||||||||||||:|||||
Mouse     1 MENSLGCVWVPKLAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCSAES 65

Human    66 DRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISR 130
            |||||||||||||:.||||||:|||||.||||||||||||||||||||||||||||.||||||||
Mouse    66 DRGVPVIKWKKDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISR 130

Human   131 TAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSG 195
            ||||.|||||||||||||:|||||||||||||||||||||||||||||||.|:||||||||||||
Mouse   131 TAKVTVAGPLRFLSQTESITAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLNPLPGDSRVVVLPSG 195

Human   196 ALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLE 260
            |||||||||||.|:||||||||||.|||||||||||||||||||||||||||||:||||||||||
Mouse   196 ALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRILSDPGLHRQLYFLQRPSNVIAIEGKDAVLE 260

Human   261 CCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAEL 325
            ||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||||
Mouse   261 CCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGTYTCVVTYKNENISASAEL 325

Human   326 TVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGV 390
            |||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||||
Mouse   326 TVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGV 390

Human   391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEA 455
            ||||||||||||||||||||:|||||||||||||||:||||||||:|||||||||||||||||||
Mouse   391 VKSDEGFYQCVAENEAGNAQSSAQLIVPKPAIPSSSILPSAPRDVLPVLVSSRFVRLSWRPPAEA 455

Human   456 KGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA 520
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 KGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA 520

Human   521 TQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKL 585
            ||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 TQPELQVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKL 585

Human   586 EGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
            |||||||||:|||||||||||||||||||||||||||||||||:|||||||||||||||||||||
Mouse   586 EGLKKFTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGT 650

Human   651 QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAET 715
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAET 715

Human   716 PENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 PENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780

Human   781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPML 845
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||:|||||
Mouse   781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPML 845

Human   846 PPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGL 910
            ||||||||||||:||||||||||||||||||:|||||||||||||||||||||||||||||||||
Mouse   846 PPVGVQAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGL 910

Human   911 KPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANG 975
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   911 KPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANG 975

Human   976 KITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPILFR 1040
            |||||||||||||||||||||||||||||||||||||:|||||||||||||.|||||||||||||
Mouse   976 KITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGVGPLSDPILFR 1040

Human  1041 TLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIVVT 1105
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||
Mouse  1041 TLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVT 1105

Human  1106 VGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKPSG 1170
            |||:||||||||||||||||||||||||||||..|||||||||||||||||||||||||||||:|
Mouse  1106 VGVLTVLVVVIVAVICTRRSSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKPTG 1170

Human  1171 TDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAKLM 1235
            |||||||||||||||||||||||||||:||||.||||||||:|||||||||||||||||.|||||
Mouse  1171 TDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAKLM 1235

Human  1236 IPMDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRSQS 1300
            |||:|||:||||||||||||||||||||||||||||||||||||||||||||||||||||||:||
Mouse  1236 IPMEAQSSNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGRTQS 1300

Human  1301 VSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTP 1365
            |||||||||.|||||:||||.||||||||||||||||||||||||||||||||||||||||||||
Mouse  1301 VSEGPTTQQQPMLPPAQPEHPSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVPYTP 1365

Human  1366 LLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSEQMA 1430
            ||||||||||||||||||||||||||||||||||||||||||||||||||.|:||||||||||||
Mouse  1366 LLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDPASVYEQDDLSEQMA 1430

Human  1431 SLEGLMKQLNAITGSAF 1447
            |||||||||||||||||
Mouse  1431 SLEGLMKQLNAITGSAF 1447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DCC	NP_005206.2	IgI_1_Neogenin_like	39..136	CDD:409387	87/96 (91%)
		Ig strand A	39..42	CDD:409387	1/2 (50%)
		Ig strand A'	45..51	CDD:409387	5/5 (100%)
		Ig strand B	55..65	CDD:409387	8/9 (89%)
		Ig strand C	70..76	CDD:409387	5/5 (100%)
		Ig strand C'	78..81	CDD:409387	1/2 (50%)
		Ig strand D	88..93	CDD:409387	4/4 (100%)
		Ig strand E	95..101	CDD:409387	5/5 (100%)
		Ig strand F	113..120	CDD:409387	6/6 (100%)
		Ig strand G	125..136	CDD:409387	10/10 (100%)
		Ig_3	139..216	CDD:464046	71/76 (93%)
		I-set	241..327	CDD:400151	83/85 (98%)
		Ig strand B	257..261	CDD:409562	3/3 (100%)
		Ig strand C	270..274	CDD:409562	3/3 (100%)
		Ig strand E	293..297	CDD:409562	3/3 (100%)
		Ig strand F	307..312	CDD:409562	3/4 (75%)
		Ig strand G	322..325	CDD:409562	2/2 (100%)
		Ig	334..417	CDD:472250	80/82 (98%)
		Ig strand B	348..352	CDD:409388	3/3 (100%)
		Ig strand C	361..365	CDD:409388	3/3 (100%)
		Ig strand E	383..387	CDD:409388	3/3 (100%)
		Ig strand F	397..402	CDD:409388	4/4 (100%)
		Ig strand G	410..413	CDD:409388	1/2 (50%)
		FN3	429..521	CDD:238020	90/91 (99%)
		FN3	<478..901	CDD:442628	415/422 (98%)
		FN3	946..1041	CDD:238020	92/94 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1152		23/25 (92%)
		Neogenin_C	1148..1445	CDD:461954	283/296 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1165..1222		52/56 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1330		37/41 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1419		23/24 (96%)
		Interaction with MYO10. /evidence=ECO:0000269|PubMed:21642953	1432..1439		6/6 (100%)
Dcc	NP_031857.2	IgI_1_Neogenin_like	39..136	CDD:409387	87/96 (91%)
		Ig strand A	39..42	CDD:409387	1/2 (50%)
		Ig strand A'	45..51	CDD:409387	5/5 (100%)
		Ig strand B	55..65	CDD:409387	8/9 (89%)
		Ig strand C	70..76	CDD:409387	5/5 (100%)
		Ig strand C'	78..81	CDD:409387	1/2 (50%)
		Ig strand D	88..93	CDD:409387	4/4 (100%)
		Ig strand E	95..101	CDD:409387	5/5 (100%)
		Ig strand F	113..120	CDD:409387	6/6 (100%)
		Ig strand G	125..136	CDD:409387	10/10 (100%)
		Ig_3	139..216	CDD:464046	71/76 (93%)
		I-set	241..327	CDD:400151	83/85 (98%)
		Ig strand B	257..261	CDD:409353	3/3 (100%)
		Ig strand C	270..274	CDD:409353	3/3 (100%)
		Ig strand E	293..297	CDD:409353	3/3 (100%)
		Ig strand F	307..312	CDD:409353	3/4 (75%)
		Ig strand G	322..325	CDD:409353	2/2 (100%)
		IgI_4_Neogenin_like	334..417	CDD:409388	80/82 (98%)
		Ig strand A	334..337	CDD:409388	2/2 (100%)
		Ig strand A'	339..343	CDD:409388	3/3 (100%)
		Ig strand B	346..355	CDD:409388	7/8 (88%)
		Ig strand C	360..366	CDD:409388	5/5 (100%)
		Ig strand C'	368..371	CDD:409388	2/2 (100%)
		Ig strand D	376..380	CDD:409388	3/3 (100%)
		Ig strand E	384..388	CDD:409388	3/3 (100%)
		Ig strand F	396..404	CDD:409388	7/7 (100%)
		Ig strand G	407..417	CDD:409388	8/9 (89%)
		FN3	429..521	CDD:238020	90/91 (99%)
		FN3	<478..901	CDD:442628	415/422 (98%)
		FN3	946..1041	CDD:238020	92/94 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1126..1153		24/26 (92%)
		Neogenin_C	1148..1445	CDD:461954	283/296 (96%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1166..1220		49/53 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1291..1329		33/37 (89%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1394..1419		23/24 (96%)