DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCC and dcc

DIOPT Version :10

Sequence 1:	NP_005206.2	Gene:	DCC / 1630	HGNCID:	2701	Length:	1447	Species:	Homo sapiens
Sequence 2:	XP_004910421.2	Gene:	dcc / 100486082	XenbaseID:	XB-GENE-852874	Length:	1448	Species:	Xenopus tropicalis

Alignment Length:	1450	Identity:	1192/1450 - (82%)
Similarity:	1323/1450 - (91%)	Gaps:	5/1450 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MENSLRCVWVPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCSAES 65
            |||||....:|||.|:|.|.:|.|.:|.|:|.|:::||:|.||||||||||||||||:|:|||:|
Frog     1 MENSLGFYSLPKLVFLLHGFALLSLNLPVSGSQVRSFTSLWFLSEPSDAVTMRGGNVVLNCSAQS 65

Human    66 DRGVPVIKWKKDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISR 130
            |||.|:|||||||::|.|.:|:|:|||.:|||||||::|||||:||||.|||||.|...|:|:||
Frog    66 DRGAPLIKWKKDGVYLNLAVDDRRQQLPSGSLLIQNVVHSRHHRPDEGFYQCEAFLDGVGTIVSR 130

Human   131 TAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSG 195
            ||||.||||||.||||||||||:|||.|||||::|||||.|.||:|::|:...|||:|::|||||
Frog   131 TAKVLVAGPLRILSQTESVTAFVGDTALLKCEIVGEPMPAISWQRNEEDVKVAPGDTRLLVLPSG 195

Human   196 ALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLE 260
            .|||||||..|.|:|||.|:||.|||.|||||:||||:.|||||..|||||.||||:||:|||||
Frog   196 TLQISRLQTADGGVYRCLAKNPGSSRVGNEAELRILSESGLHRQQVFLQRPGNVVAVEGQDAVLE 260

Human   261 CCVSGYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAEL 325
            |.|||||.|:..||:|:|::.:|::|||:|||||||||||||||:|.|||:.||||||.|.||:|
Frog   261 CAVSGYPTPTIVWLQGDELVPIRTRKYSVLGGSNLLISNVTDDDAGTYTCMATYKNENTSFSADL 325

Human   326 TVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGV 390
            ||:|||.|||||:||||||||||||||.|||||.|||.|.|||:||||||||||||||||||||:
Frog   326 TVMVPPRFLNHPANLYAYESMDIEFECAVSGKPSPTVKWTKNGEVVIPSDYFQIVGGSNLRILGL 390

Human   391 VKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPAEA 455
            ||||||:|||:|||||||.||.||||:|.||:||||||||||||||||||||||||||||||.|.
Frog   391 VKSDEGYYQCIAENEAGNIQTYAQLIIPDPAVPSSSVLPSAPRDVVPVLVSSRFVRLSWRPPVEP 455

Human   456 KGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVA 520
            :|||||:||:||::|..||||:||:||.:||||||||.||..|.|||||||||||||||||:||.
Frog   456 RGNIQTYTVYFSKQGAQRERAVNTSQPIALQLTVGNLAPEETYNFRVVAYNEWGPGESSQPVKVG 520

Human   521 TQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKL 585
            |||||||||||||||.|||:|||:||:||.|||||||||||||||:|..:|:|||||||||.|:|
Frog   521 TQPELQVPGPVENLQVVSTAPTSVLISWEAPAYANGPVQGYRLFCSETFSGREQNIEVDGLLYRL 585

Human   586 EGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGT 650
            |||:||||||:|.|||||||||||:::..||||||||||.||||||||||||:||||||||||||
Frog   586 EGLRKFTEYSIRVLAYNRYGPGVSSEEHAVVTLSDVPSAMPQNVSLEVVNSRNIKVSWLPPPSGT 650

Human   651 QNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAET 715
            |||||||||||||||||||::||:||||||||||||||||||||||:|||||||||.|:||||||
Frog   651 QNGFITGYKIRHRKTTRRGDLETIEPNNLWYLFTGLEKGSQYSFQVAAMTVNGTGPSSDWYTAET 715

Human   716 PENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780
            |||||||||||||||||||||.|..||||||||||||||||||||||||||||||||||||||||
Frog   716 PENDLDESQVPDQPSSLHVRPLTTSIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780

Human   781 YSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDP--VDYYPLLDDFPTSVPDLSTP 843
            ||||.||.||||||||||||||||||||||||||||.|||.||  :::||.:|||||||||:|||
Frog   781 YSIENLEPSSHYVISLKAFNNAGEGVPLYESATTRSQTDPIDPLEIEFYPFIDDFPTSVPDMSTP 845

Human   844 MLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTAT 908
            ||||||||||||||||||||||||||.|||||:|||.||:|||||:|||:||||.||||||:|.|
Frog   846 MLPPVGVQAVALTHDAVRVSWADNSVIKNQKTAEVRFYTIRWRTSYSASSKYKSADTTSLSHTVT 910

Human   909 GLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEA 973
            ||||||||||||||||.||||||||||||||||.|||||||||||||||.||||||||||||:||
Frog   911 GLKPNTMYEFSVMVTKGRRSSTWSMTAHATTYETAPTSAPKDLTVITRERKPRAVIVSWQPPIEA 975

Human   974 NGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDPIL 1038
            ||||..||||||||||:.||||:|.||:||||||:|:||||||.|||||||||:||:|||||||.
Frog   976 NGKIIDYILFYTLDKNLQIDDWVMVTITGDRLTHEILDLNLDTAYYFRIQARNAKGLGPLSDPIT 1040

Human  1039 FRTLKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVIIV 1103
            |||.|||||||||||||||||||||.|||||||||:|||||||||||||||||||||||||||||
Frog  1041 FRTPKVEHPDKMANDQGRHGDGGYWSVDTNLIDRSSLNEPPIGQMHPPHGSVTPQKNSNLLVIIV 1105

Human  1104 VTVGVITVLVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1168
            ||||.||::||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog  1106 VTVGAITIVVVVIVAVICTRRSSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1170

Human  1169 SGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTLERSLAARRAPRAK 1233
            ||:|..|||||.|||||:|||||||||:|||||||||||.|.:|.||::|||||:||||||.|||
Frog  1171 SGSDTQGRDSPRQSCQDITPVSHSQSESQLGSKSTSHSGPDADEVGSNISTLERTLAARRATRAK 1235

Human  1234 LMIPMDAQ-SNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRGFGAGR 1297
            ||||||:| |:||.||||||||||||||||||||||||||||||||||||||||||:|||||:
Frog  1236 LMIPMDSQPSSNPPVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSMDRGFGS-- 1298

Human  1298 SQSVSEGPTTQQPPMLPPSQPEHSSSEEAPSRTIPTACVRPTHPLRSFANPLLPPPMSAIEPKVP 1362
            |::|:|.|.:||..:|...||||||||:|||||||||||||||||||||||||||||:|:|||||
Frog  1299 SRAVTEVPASQQSSVLSHPQPEHSSSEDAPSRTIPTACVRPTHPLRSFANPLLPPPMTAMEPKVP 1363

Human  1363 YTPLLSQPGPTLPKTHVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKPTEDSANVYEQDDLSE 1427
            |||||||.|.:|||..|||||||||||||||||||||||||||||||||.|:|.::|||||||||
Frog  1364 YTPLLSQTGASLPKAQVKTASLGLAGKARSPLLPVSVPTAPEVSEESHKHTDDPSSVYEQDDLSE 1428

Human  1428 QMASLEGLMKQLNAITGSAF 1447
            ||||||||||||||||||||
Frog  1429 QMASLEGLMKQLNAITGSAF 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCC	NP_005206.2	IgI_1_Neogenin_like	39..136	CDD:409387	70/96 (73%)
		Ig strand A	39..42	CDD:409387	1/2 (50%)
		Ig strand A'	45..51	CDD:409387	5/5 (100%)
		Ig strand B	55..65	CDD:409387	7/9 (78%)
		Ig strand C	70..76	CDD:409387	4/5 (80%)
		Ig strand C'	78..81	CDD:409387	1/2 (50%)
		Ig strand D	88..93	CDD:409387	3/4 (75%)
		Ig strand E	95..101	CDD:409387	5/5 (100%)
		Ig strand F	113..120	CDD:409387	5/6 (83%)
		Ig strand G	125..136	CDD:409387	8/10 (80%)
		Ig_3	139..216	CDD:464046	53/76 (70%)
		I-set	241..327	CDD:400151	60/85 (71%)
		Ig strand B	257..261	CDD:409562	3/3 (100%)
		Ig strand C	270..274	CDD:409562	0/3 (0%)
		Ig strand E	293..297	CDD:409562	3/3 (100%)
		Ig strand F	307..312	CDD:409562	3/4 (75%)
		Ig strand G	322..325	CDD:409562	2/2 (100%)
		Ig	334..417	CDD:472250	71/82 (87%)
		Ig strand B	348..352	CDD:409388	3/3 (100%)
		Ig strand C	361..365	CDD:409388	2/3 (67%)
		Ig strand E	383..387	CDD:409388	3/3 (100%)
		Ig strand F	397..402	CDD:409388	3/4 (75%)
		Ig strand G	410..413	CDD:409388	2/2 (100%)
		FN3	429..521	CDD:238020	73/91 (80%)
		FN3	<478..901	CDD:442628	365/424 (86%)
		FN3	946..1041	CDD:238020	79/94 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1152		25/25 (100%)
		Neogenin_C	1148..1445	CDD:461954	250/297 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1165..1222		44/56 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330		24/41 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419		20/24 (83%)
		Interaction with MYO10. /evidence=ECO:0000269\|PubMed:21642953	1432..1439		6/6 (100%)
dcc	XP_004910421.2	IgI_1_Neogenin_like	39..136	CDD:409387	70/96 (73%)
		Ig strand A	39..42	CDD:409387	1/2 (50%)
		Ig strand A'	45..51	CDD:409387	5/5 (100%)
		Ig strand B	55..65	CDD:409387	7/9 (78%)
		Ig strand C	70..76	CDD:409387	4/5 (80%)
		Ig strand C'	78..81	CDD:409387	1/2 (50%)
		Ig strand D	88..93	CDD:409387	3/4 (75%)
		Ig strand E	95..101	CDD:409387	5/5 (100%)
		Ig strand F	113..120	CDD:409387	5/6 (83%)
		Ig strand G	125..136	CDD:409387	8/10 (80%)
		Ig_3	139..216	CDD:464046	53/76 (70%)
		FN3	262..780	CDD:442628	430/517 (83%)
		Ig	334..417	CDD:472250	71/82 (87%)
		Ig strand B	348..352	CDD:409388	3/3 (100%)
		Ig strand C	361..365	CDD:409388	2/3 (67%)
		Ig strand E	383..387	CDD:409388	3/3 (100%)
		Ig strand F	397..402	CDD:409388	3/4 (75%)
		Ig strand G	410..413	CDD:409388	2/2 (100%)
		FN3	592..>1043	CDD:442628	394/450 (88%)
		Neogenin_C	1150..1446	CDD:461954	250/297 (84%)

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DRSC/TRiP Functional Genomics Resources

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCC and dcc

DIOPT Version :10

Known Domains:

Indicated by green bases in alignment.