Protein Alignment DBT and LAT1

DIOPT Version :9

• Sequence 1: NP_001909.4
• Gene: DBT / 1629
• HGNCID: 2698
• Length: 482
• Species: Homo sapiens
• Sequence 2: NP_014328.3
• Gene: LAT1 / 855653
• SGDID: S000005015
• Length: 482
• Species: Saccharomyces cerevisiae
• Alignment Length: 486
• Identity: 130/486 - (26%)
• Similarity: 208/486 - (42%)
• Gaps: 87/486 - (17%)

Human    48 SHPHHFLKTTAALRGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITS 112
            |:|.|.:....||...:.|..|:            .|..||||.:|..:.|.|:::|||.:....
Yeast    30 SYPEHTIIGMPALSPTMTQGNLA------------AWTKKEGDQLSPGEVIAEIETDKAQMDFEF 82

Human   113 RYDGVIKKLYY--NLDDIAYVGKPL-VDIETEA---------LKDSEED--------VVETPAVS 157
            :.||.:.|:..  ...||. |.||: |.:|.:|         |:||..|        ..|..|..
Yeast    83 QEDGYLAKILVPEGTKDIP-VNKPIAVYVEDKADVPAFKDFKLEDSGSDSKTSTKAQPAEPQAEK 146

Human   158 HDEHTHQEIK---------------GRKTLATPAVRRLAMENNIKLSEVVGSGKDGRILKEDILN 207
            ..|...:|.|               || ..|:|..:.:|:|..|.|.:|.|:|..|||.|.||.:
Yeast   147 KQEAPAEETKTSAPEAKKSDVAAPQGR-IFASPLAKTIALEKGISLKDVHGTGPRGRITKADIES 210

Human   208 YLEK------QTGAILPPSPKVEIMP----PPPKPKDMT----VPILVSKPPVFTGKDKTEPIKG 258
            ||||      ||......:|......    ..|.|....    |||...:..:  |:...:..:|
Yeast   211 YLEKSSKQSSQTSGAAAATPAAATSSTTAGSAPSPSSTASYEDVPISTMRSII--GERLLQSTQG 273

Human   259 FQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLSFMPFFLKAASLGLLQFP 323
                          ||.:....:|.:::|:|||:.|...|..: .|||.....:||.::...:.|
Yeast   274 --------------IPSYIVSSKISISKLLKLRQSLNATANDK-YKLSINDLLVKAITVAAKRVP 323

Human   324 ILNASVDENCQNITYKASH-NIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLS 387
            ..||....| :|:..|..: ::.:|:.|..||:.|.|||.:...:..|:.|:..|.|...:::|:
Yeast   324 DANAYWLPN-ENVIRKFKNVDVSVAVATPTGLLTPIVKNCEAKGLSQISNEIKELVKRARINKLA 387

Human   388 TTDLTGGTFTLSNIGSIGG-TFAKPVIMPPEVAIGALGSIKAI---PRFNQKGEVYKAQIMNVSW 448
            ..:..|||..:||:|.... .....:|.||:..|.|:.:::.:   ....:.|..:..|: .::.
Yeast   388 PEEFQGGTICISNMGMNNAVNMFTSIINPPQSTILAIATVERVAVEDAAAENGFSFDNQV-TITG 451

Human   449 SADHRVIDGATMSRFSNLWKSYLENPAFMLL 479
            :.|||.||||..:.|....|:.:|||..|||
Yeast   452 TFDHRTIDGAKGAEFMKELKTVIENPLEMLL 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	124/467 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..168		6/43 (14%)
LAT1	NP_014328.3	PDHac_trf_mito	36..482	CDD:273567	125/478 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810