DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DBT and dbt

DIOPT Version :9

Sequence 1:	NP_001909.4	Gene:	DBT / 1629	HGNCID:	2698	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_001016963.1	Gene:	dbt / 549717	XenbaseID:	XB-GENE-965456	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	501	Identity:	370/501 - (73%)
Similarity:	424/501 - (84%)	Gaps:	28/501 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNY----VCFFGYPSFKYSH----PHHFLKTT 57
            |||||.||:.:|:.|:.:.:|...:||.:.:|:.::    .|         .|    ||..|:||
Frog     1 MAAVRALRSCNRSLGRWVGLRQLGSCGQIRILRSSFPRKTPC---------RHLQQIPHRSLRTT 56

Human    58 AALRGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLY 122
            |.|.||:||||||||||||.|||||:|||||||:|||||||||||||||||||||||||||:||:
Frog    57 AVLNGQIVQFKLSDIGEGITEVTVKDWYVKEGDSVSQFDSICEVQSDKASVTITSRYDGVIRKLH 121

Human   123 YNLDDIAYVGKPLVDIETEALKD--SEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENN 185
            ||:||.||||||||||||:||||  .||||||||||||||||||||||.||||||||||||||||
Frog   122 YNVDDTAYVGKPLVDIETDALKDVAPEEDVVETPAVSHDEHTHQEIKGHKTLATPAVRRLAMENN 186

Human   186 IKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPP---------KPKDMTVPILV 241
            |||||||||||||||||||||::|.|||||||||||::||.||||         |.|..::|..:
Frog   187 IKLSEVVGSGKDGRILKEDILSFLAKQTGAILPPSPQMEITPPPPKLETSTQQQKAKAASIPAPM 251

Human   242 SKPPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLS 306
            .||.||||||.|||:|||.|||||||||||||||||||||:|:|.|.:|||:|||:|.:||::||
Frog   252 IKPVVFTGKDVTEPLKGFHKAMVKTMSAALKIPHFGYCDEVDMTNLSRLREDLKPLAESRGVRLS 316

Human   307 FMPFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIA 371
            |||||||||||||:||||||:|||||||||||||:|||||||||.||||||||||||:.|||:||
Frog   317 FMPFFLKAASLGLMQFPILNSSVDENCQNITYKAAHNIGIAMDTHQGLIVPNVKNVQVRSIFEIA 381

Human   372 TELNRLQKLGSVSQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKG 436
            .||||||.|||..||...||||||||||||||||||:|||||:||||||||:|.::.:|||:.||
Frog   382 AELNRLQSLGSTGQLGAGDLTGGTFTLSNIGSIGGTYAKPVILPPEVAIGAIGKVQVLPRFDSKG 446

Human   437 EVYKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK 482
            :|.||||:|:|||||||:||||||||||||||||||||:.|||:||
Frog   447 QVVKAQIINISWSADHRIIDGATMSRFSNLWKSYLENPSLMLLELK 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	342/425 (80%)
DBT	NP_001909.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..168		20/20 (100%)
dbt	NP_001016963.1	lipoyl_domain	64..137	CDD:133458	65/72 (90%)
		PLN02528	66..492	CDD:215289	342/425 (80%)
		E3_binding	173..206	CDD:280908	32/32 (100%)
		2-oxoacid_dh	277..489	CDD:278621	169/211 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	387	1.000	Domainoid score	I6350
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	735	1.000	Inparanoid score	I5040
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D122511at32523
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto159080
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3954
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	14.110