DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DBT and dbt

DIOPT Version :9

Sequence 1:	NP_001909.4	Gene:	DBT / 1629	HGNCID:	2698	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_001013533.1	Gene:	dbt / 541388	ZFINID:	ZDB-GENE-050320-85	Length:	493	Species:	Danio rerio

Alignment Length:	499	Identity:	343/499 - (68%)
Similarity:	393/499 - (78%)	Gaps:	23/499 - (4%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAVRMLRTWSRNAGKLICVRYFQTC-----GNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAAL 60
            ||||..:|.......:|:..|..:.|     ....||:|:     .| |......|.:..|:...
Zfish     1 MAAVITVRAPFVFMRRLVSARLHRNCCSKLPAACLVLRPH-----SY-SLVAGRQHRYFHTSYVA 59

Human    61 RGQVVQFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNL 125
            ...:||||||||||||.|||||||||||||.|||||||||||||||||||||||||||:||||::
Zfish    60 ARPIVQFKLSDIGEGIMEVTVKEWYVKEGDKVSQFDSICEVQSDKASVTITSRYDGVIRKLYYDV 124

Human   126 DDIAYVGKPLVDIETEA--LKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENNIKL 188
            |.||.||||||||||:.  .:..:||||||||||.:||:.|||||.||.||||||||||||||||
Zfish   125 DSIALVGKPLVDIETDGGQAESPQEDVVETPAVSQEEHSPQEIKGHKTQATPAVRRLAMENNIKL 189

Human   189 SEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPP----------KPKDMTVPILVSK 243
            |||||:|||||||||||||::.|||||||||:|..||.|.||          |....:|||.|..
Zfish   190 SEVVGTGKDGRILKEDILNFIAKQTGAILPPAPFQEIRPQPPAAAAPLTPSAKATPPSVPIPVIP 254

Human   244 PPVFTGKDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLSFM 308
            .|||||||.||||||||||||||||||||||||||.||:||::||:||.|||.:..:||:|||:|
Zfish   255 KPVFTGKDHTEPIKGFQKAMVKTMSAALKIPHFGYKDEVDLSQLVRLRSELKGLTESRGVKLSYM 319

Human   309 PFFLKAASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIATE 373
            |||:|||||.||.|||||:|:||||.:|||||:||||:||||.|||:||||||:|:.|:|:||.|
Zfish   320 PFFIKAASLALLHFPILNSSLDENCTSITYKAAHNIGLAMDTSQGLLVPNVKNIQMLSVFEIAVE 384

Human   374 LNRLQKLGSVSQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEV 438
            |||||.||:..||.|:||||||||||||||||||:|||||:||||||||||.|:.:||||.|.||
Zfish   385 LNRLQILGASGQLGTSDLTGGTFTLSNIGSIGGTYAKPVILPPEVAIGALGKIQVLPRFNHKDEV 449

Human   439 YKAQIMNVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK 482
            .||.|||||||||||:||||||.||||||:|||||||.|:||||
Zfish   450 VKAHIMNVSWSADHRIIDGATMCRFSNLWRSYLENPASMVLDLK 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	324/426 (76%)
DBT	NP_001909.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..168		15/20 (75%)
dbt	NP_001013533.1	lipoyl_domain	64..137	CDD:133458	65/72 (90%)
		PLN02528	66..493	CDD:215289	324/426 (76%)
		E3_binding	174..206	CDD:280908	30/31 (97%)
		2-oxoacid_dh	278..490	CDD:278621	161/211 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343599
Domainoid	1	1.000	320	1.000	Domainoid score	I6818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	612	1.000	Inparanoid score	I5130
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D188265at7742
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto47107
orthoMCL	1	0.900	-	-		OOG6_101891
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.410