DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DBT and Dbt

DIOPT Version :9

Sequence 1:	NP_001909.4	Gene:	DBT / 1629	HGNCID:	2698	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_445764.1	Gene:	Dbt / 29611	RGDID:	68403	Length:	482	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	422/482 - (87%)
Similarity:	452/482 - (93%)	Gaps:	0/482 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAALRGQVV 65
            |||.|:|.||||||.:|.|||||||..|||:|||.:||..|||..|.|.|.|.|:|.|.|:||||
  Rat     1 MAAARVLGTWSRNAVRLTCVRYFQTYNNVHILKPQHVCSVGYPLLKSSQPRHSLRTAAVLQGQVV 65

Human    66 QFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAY 130
            |||||||||||||||:||||||||||||||||||||||||||||||||||||||:||||||||||
  Rat    66 QFKLSDIGEGIREVTIKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKRLYYNLDDIAY 130

Human   131 VGKPLVDIETEALKDSEEDVVETPAVSHDEHTHQEIKGRKTLATPAVRRLAMENNIKLSEVVGSG 195
            |||||:||||||||||||||||||||:|||||||||||:||||||||||||||||||||||||||
  Rat   131 VGKPLIDIETEALKDSEEDVVETPAVAHDEHTHQEIKGQKTLATPAVRRLAMENNIKLSEVVGSG 195

Human   196 KDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPPVFTGKDKTEPIKGFQ 260
            ||||||||||||:||||||||||||||.||.||||:|:|...|..|||||||.|||:|||:.|||
  Rat   196 KDGRILKEDILNFLEKQTGAILPPSPKSEITPPPPQPRDRPFPTPVSKPPVFLGKDRTEPVTGFQ 260

Human   261 KAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLSFMPFFLKAASLGLLQFPIL 325
            |||||||||||||||||||||:||||||||||||||:|.||||||||||||||||||||||||||
  Rat   261 KAMVKTMSAALKIPHFGYCDEVDLTELVKLREELKPVALARGIKLSFMPFFLKAASLGLLQFPIL 325

Human   326 NASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQKLGSVSQLSTTD 390
            |||||||||:||||||||||||||||:|||||||||||:.|:|:||.||||||||||:.||||||
  Rat   326 NASVDENCQSITYKASHNIGIAMDTERGLIVPNVKNVQVRSVFEIAMELNRLQKLGSLGQLSTTD 390

Human   391 LTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIMNVSWSADHRVI 455
            |||||||||||||||||:|||||:||||||||||:|||:|||:|||:||||||||||||||||||
  Rat   391 LTGGTFTLSNIGSIGGTYAKPVILPPEVAIGALGAIKALPRFDQKGDVYKAQIMNVSWSADHRVI 455

Human   456 DGATMSRFSNLWKSYLENPAFMLLDLK 482
            |||||||||||||||||||||||||||
  Rat   456 DGATMSRFSNLWKSYLENPAFMLLDLK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	377/414 (91%)
DBT	NP_001909.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..168		19/20 (95%)
Dbt	NP_445764.1	lipoyl_domain	65..138	CDD:133458	69/72 (96%)
		PLN02528	67..482	CDD:215289	377/414 (91%)
		E3_binding	172..205	CDD:280908	32/32 (100%)
		2-oxoacid_dh	267..479	CDD:278621	193/211 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696376
Domainoid	1	1.000	427	1.000	Domainoid score	I9815
eggNOG	1	0.900	-	-		E1_COG0508
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	857	1.000	Inparanoid score	I6856
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D122511at32523
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto143495
orthoMCL	1	0.900	-	-		OOG6_101891
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.270