DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DBT and dbt-1

DIOPT Version :9

Sequence 1:	NP_001909.4	Gene:	DBT / 1629	HGNCID:	2698	Length:	482	Species:	Homo sapiens
Sequence 2:	NP_495670.1	Gene:	dbt-1 / 174279	WormBaseID:	WBGene00014054	Length:	448	Species:	Caenorhabditis elegans

Alignment Length:	493	Identity:	249/493 - (50%)
Similarity:	315/493 - (63%)	Gaps:	56/493 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAVRMLRTWSRNAGKLICVRYFQTCGNVHVLKPNYVCFFGYPSFKYSHPHHFLKTTAALRGQVV 65
            |.|.|:|.|.|         |.|:...::|..|   |.|.                      .||
Worm     1 MMAARLLGTSS---------RIFKLNKHLHTSK---VAFM----------------------PVV 31

Human    66 QFKLSDIGEGIREVTVKEWYVKEGDTVSQFDSICEVQSDKASVTITSRYDGVIKKLYYNLDDIAY 130
            |||||||||||.||.|||||||||||:||||.:||||||||:|||:.||||::||||:.:|.:|.
Worm    32 QFKLSDIGEGIAEVQVKEWYVKEGDTISQFDKVCEVQSDKAAVTISCRYDGIVKKLYHEVDGMAR 96

Human   131 VGKPLVDIETEA--------LKDSEEDVVETP---AVSHDEHTHQEIKGRKTLATPAVRRLAMEN 184
            ||:.|:|:|.|.        .|::.....|.|   |....|..|.|   .|.||||||||:|:||
Worm    97 VGQALIDVEIEGNVEEPEQPKKEAASSSPEAPKSSAPKAPESAHSE---GKVLATPAVRRIAIEN 158

Human   185 NIKLSEVVGSGKDGRILKEDILNYLEKQTGAILPPSPKVEIMPPPPKPKDMTVPILVSKPPVFTG 249
            .|||:||.|:|||||:||||:|.:|.:........|..:......|:|...:...|        .
Worm   159 KIKLAEVRGTGKDGRVLKEDVLKFLGQVPADHTSGSTNIRTTHQAPQPSSKSYEPL--------K 215

Human   250 KDKTEPIKGFQKAMVKTMSAALKIPHFGYCDEIDLTELVKLREELKPIAFARGIKLSFMPFFLKA 314
            :|...||:|:.:||||||:.|||||||||.|||::..|||.|.|||..|..|.||||:||||:||
Worm   216 EDVAVPIRGYTRAMVKTMTEALKIPHFGYNDEINVDSLVKYRAELKEFAKERHIKLSYMPFFIKA 280

Human   315 ASLGLLQFPILNASVDENCQNITYKASHNIGIAMDTEQGLIVPNVKNVQICSIFDIATELNRLQK 379
            |||.||::|.||::.||..:|:.:||||||.:||||..||:|||:||.:..|||:||.|||||.:
Worm   281 ASLALLEYPSLNSTTDEKMENVIHKASHNICLAMDTPGGLVVPNIKNCEQRSIFEIAQELNRLLE 345

Human   380 LGSVSQLSTTDLTGGTFTLSNIGSIGGTFAKPVIMPPEVAIGALGSIKAIPRFNQKGEVYKAQIM 444
            .|...|:...||..|||:|||||:||||:|.||:.||:|||||:|.|:.:|||::...|....||
Worm   346 AGKKQQIKREDLIDGTFSLSNIGNIGGTYASPVVFPPQVAIGAIGKIEKLPRFDKHDNVIPVNIM 410

Human   445 NVSWSADHRVIDGATMSRFSNLWKSYLENPAFMLLDLK 482
            .|||.|||||:|||||:||||.||.|||:|:.||..||
Worm   411 KVSWCADHRVVDGATMARFSNRWKFYLEHPSAMLAQLK 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DBT	NP_001909.4	PLN02528	67..482	CDD:215289	232/425 (55%)
DBT	NP_001909.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..168		6/23 (26%)
dbt-1	NP_495670.1	lipoyl_domain	31..104	CDD:133458	53/72 (74%)
		PLN02528	33..448	CDD:215289	232/425 (55%)
		E3_binding	146..179	CDD:280908	25/32 (78%)
		2-oxoacid_dh	233..445	CDD:278621	128/211 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161472074
Domainoid	1	1.000	282	1.000	Domainoid score	I979
eggNOG	1	0.900	-	-		E1_COG0508
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1444
Inparanoid	1	1.050	450	1.000	Inparanoid score	I998
Isobase	1	0.950	-	0	Normalized mean entropy	S1721
OMA	1	1.010	-	-		QHG61710
OrthoDB	1	1.010	-	-		D428202at33208
OrthoFinder	1	1.000	-	-		FOG0005815
OrthoInspector	1	1.000	-	-		oto22077
orthoMCL	1	0.900	-	-		OOG6_101891
Panther	1	1.100	-	-	LDO	PTHR43178
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3954
SonicParanoid	1	1.000	-	-		X4793
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790