DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KRT28 and cyt1l

DIOPT Version :9

Sequence 1:	NP_853513.2	Gene:	KRT28 / 162605	HGNCID:	30842	Length:	464	Species:	Homo sapiens
Sequence 2:	NP_001076351.1	Gene:	cyt1l / 792062	ZFINID:	ZDB-GENE-061026-4	Length:	429	Species:	Danio rerio

Alignment Length:	447	Identity:	205/447 - (45%)
Similarity:	282/447 - (63%)	Gaps:	29/447 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     6 SNGSRHVCLRSGAGSVRPLNGGAGFAGSSACGGSVAGSEFSCALGGGLGSVPGGSHAGGALGNAA 70
            |.||..:.:..|||.|..:..|:.:.|:...|..::.|..|.:...|     ||:..||..|
Zfish    11 SGGSSRLSVGGGAGRVSGVRAGSVYGGAGGSGVRISSSSASRSFSAG-----GGAGFGGGAG--- 67

Human    71 CIGFAGSEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKGWYEKYGPGSCRGLDH 135
             .||..|:...:|.|||.|||||||||||||:.||:||:|||:||.||:.:.:.....:.|
Zfish    68 -AGFNLSDAIDVSTNEKATMQNLNDRLASYLEKVRSLEKANADLELKIRQFLDSKATPNAR---- 127

Human   136 DYSRYHLTIEDLKNKIISSTTTNANVILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVL 200
            |||.|:.||.||:.||:.:|..|..:.|.||||:|||||||:|||||||:.|:|||||.|||:||
Zfish   128 DYSAYYATISDLQAKILHATGVNGGIYLSIDNAKLAADDFRVKYENELTMRQSVEADIVGLRKVL 192

Human   201 DELTLCRTDQELQYESLSEEMTYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLAVLLNNMRAE 265
            ||||:.|:|.|||.|.|.||:.:||||||||:.|.:....|.||||::|||..||..::.::|..
Zfish   193 DELTMTRSDLELQIEGLKEELIFLKKNHEEELLAARTQMSGQVNVEVDAAPQEDLTKIMADIREH 257

Human   266 YEALAEQNRKDAEAWFNEKSASLQQQISHDSGAATFARSQLTEMRRTLQTLEIQLQSLMATKHSL 330
            |||::.:||||.|:||..||.||.::::..:.....:||::||::||||:|||:|||.::.|.||
Zfish   258 YEAVSAKNRKDLESWFQAKSESLNKEVAVSTETLQTSRSEITEVKRTLQSLEIELQSQLSMKASL 322

Human   331 ECSLTETESNYCTQLAQIQAQIGALEEQLHQVRTETEGQKLEYEHLLDVKVHLEKEIETYCRLID 395
            |.:|.:|::.|...|...|.|:.:|||||.|:|.:.|.|..||:.|||:|..||.||..|.||:|
Zfish   323 EGTLADTQARYTNMLNGYQFQVSSLEEQLIQLRADLERQGQEYQMLLDIKTRLEMEIAEYRRLLD 387

Human   396 GDGNSCSKSKGFGSGSPGNSSKDLSKTTLVKTVVEELDQRGKVLSSRIH-SIEEKTS 451
            |:..|.|.|.              |.|..|.|:|||:.. |||:||... :.|.||:
Zfish   388 GEATSVSTSS--------------STTRKVVTIVEEVVD-GKVVSSSSKATTETKTT 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KRT28	NP_853513.2	Head. /evidence=ECO:0000255	1..85		22/78 (28%)
		Filament	85..396	CDD:278467	163/310 (53%)
		Coil 1A. /evidence=ECO:0000255	86..121		26/34 (76%)
		Linker 1. /evidence=ECO:0000255	122..143		5/20 (25%)
		Coil 1B. /evidence=ECO:0000255	144..235		58/90 (64%)
		Linker 12. /evidence=ECO:0000255	236..258		10/21 (48%)
		Coil 2. /evidence=ECO:0000255	259..397		62/137 (45%)
		Tail. /evidence=ECO:0000255	398..464		18/55 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..464		3/10 (30%)
cyt1l	NP_001076351.1	Filament	81..389	CDD:278467	164/311 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28M49
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23239
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910