DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Il6st and Dscam1

DIOPT Version :9

Sequence 1:	NP_034690.3	Gene:	Il6st / 16195	MGIID:	96560	Length:	917	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	769	Identity:	163/769 - (21%)
Similarity:	270/769 - (35%)	Gaps:	192/769 - (24%)

- Green bases have known domain annotations that are detailed below.

Mouse    65 IVWKTNHAAVP---------REQV--------TVINRTTSSVTFTDVVLPSVQLTCNILSFGQIE 112
            |:|..|:..:.         ||::        ..|.||..|        .|...||       :.
  Fly   850 ILWNMNNMRLDPKNDNRYTIREEILSTGVMSSLSIKRTERS--------DSALFTC-------VA 899

Mouse   113 QNVYG-----VTMLSGFPPDKPTNLTCIVNEGKNMLCQW------DPGRETYLETNYTLKSEWAT 166
            .|.:|     :.|:....|:.|..|..:...|:::...|      :...:.|:......::.| :
  Fly   900 TNAFGSDDASINMIVQEVPEMPYALKVLDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASW-S 963

Mouse   167 EKFPDCQSKHGTSCMVSYM-PTYYVNIEVWVEAENALG-KVSSESINFDPVDKVKPTPPYNLSVT 229
            |........|.|...|..: |....||.  :.||||:| ..|||::.....::.....|.|:.|.
  Fly   964 EIDRVIVPGHTTEAQVQKLSPATTYNIR--IVAENAIGTSQSSEAVTIITAEEAPSGKPQNIKVE 1026

Mouse   230 NSEELSSIL------KLSWVSSGLGGLLDLKSDIQYRTKDASTWIQVPLEDTMSPRTSFTVQDLK 288
            ...:.:..:      :..|....||..:..|..   .|..:..:..:..........:..:|:|:
  Fly  1027 PVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLS---NTNSSYVFETINFITEEGKEHNLELQNLR 1088

Mouse   289 PFTEYVFRIRSIKDSGKGYWSDWSEEASGTTYEDRPSRPPSFWYKTNPSHGQEYRSVRLIWKALP 353
            .:|:|...|::....|.|   ..|||....|.|..||:|||....|..:.    :::|:.|.:.|
  Fly  1089 VYTQYSVVIQAFNKIGAG---PLSEEEKQFTAEGTPSQPPSDTACTTLTS----QTIRVGWVSPP 1146

Mouse   354 LSEANGKILDYEVILTQS----KSVSQTYTVTGTELTV-----NLTNDRYVASLAARNKVGKSAA 409
            |..|||.|..|:|:...|    ....:.|..|.:..||     ..||  |...:.|....|.
  Fly  1147 LESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTN--YTMQVLATTAGGD--- 1206

Mouse   410 AVLTIP-----SPHVTAAYSVVNLKAFPKDN-LLWVEWTPPPKPVSKYILEWCVLSENAPCVEDW 468
            .|.::|     .|.|..|  ..::||....| .:.|.|.||.:| :..|.::.|.|:    .|..
  Fly  1207 GVRSVPIHCQTEPDVPEA--PTDVKALVMGNAAILVSWRPPAQP-NGIITQYTVYSK----AEGA 1264

Mouse   469 QQEDATVNRTHLR-----GRLLESKCYQITVTPVFATGPG-GSESLKAYLKQAAPARGP------ 521
            :.|..|....|.:     ..|.::|.|:..||.....|.| .|:|:.|......||:..
  Fly  1265 ETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAKIASFDDTF 1329

Mouse   522 TVRTKK--------VGKNEAVLAW----------DQIPV-DDQNGFIR--------NYSISYRTS 559
            |...|:        ||..:..:.|          |::.| .|.:..|:        :||.....|
  Fly  1330 TATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVNRQDAGDYSCHAENS 1394

Mouse   560 VGKEMVVH-------VDSSHTEYTLSSLSSDTLYMVRMAAYTDEGGKDGPEFTFT---TPKFAQG 614
            :.|:.:.|       ..|.|.  |||:.::|.| .|::..:.   |...|...:|   .|:|.:.
  Fly  1395 IAKDSITHKLIVLAPPQSPHV--TLSATTTDAL-TVKLKPHE---GDTAPLHGYTLHYKPEFGEW 1453

Mouse   615 EIEAIVVP---------VCLAFLLTTLLGVLFCFNK------RDLIK---KHIWPNVPDPSK--- 658
            |...:.|.         :|.:.......|    ||.      .|::.   |...|.:|:..:
  Fly  1454 ETSEVSVDSQKHNIEGLLCGSRYQVYATG----FNNIGAGEASDILNTRTKGQKPKLPEKPRFIE 1514

Mouse   659 -------SHIAQWSPHTPPRHNF----NSKDQMYSDGNFTDVSVVEIEANNKKP 701
                   .|...|.....|..:|    ..:||:    .:..:|      ||.||
  Fly  1515 VSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQI----EWNQIS------NNVKP 1558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Il6st	NP_034690.3	Lep_receptor_Ig	26..112	CDD:399379	12/63 (19%)
		FN3	125..213	CDD:419708	22/95 (23%)
		FN3	220..319	CDD:238020	18/104 (17%)
		WSXWS motif	308..312		0/3 (0%)
		FN3	521..597	CDD:214495	22/115 (19%)
		Box 1 motif	649..657		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..678		4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	719..754
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	898..917
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706
		I-set	819..914	CDD:254352	15/78 (19%)
		Ig	833..921	CDD:299845	16/85 (19%)
		FN3	918..1011	CDD:238020	22/95 (23%)
		FN3	1018..1116	CDD:238020	18/103 (17%)
		FN3	1124..1217	CDD:238020	26/101 (26%)
		FN3	1222..1312	CDD:238020	25/96 (26%)
		Ig	1339..1406	CDD:299845	12/66 (18%)
		FN3	1409..1499	CDD:238020	20/99 (20%)
		FN3	1504..1584	CDD:238020	13/65 (20%)
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910