DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Il6st and Nrg

DIOPT Version :9

Sequence 1:NP_034690.3 Gene:Il6st / 16195 MGIID:96560 Length:917 Species:Mus musculus
Sequence 2:NP_001245581.1 Gene:Nrg / 31792 FlyBaseID:FBgn0264975 Length:1309 Species:Drosophila melanogaster


Alignment Length:852 Identity:179/852 - (21%)
Similarity:291/852 - (34%) Gaps:267/852 - (31%)


- Green bases have known domain annotations that are detailed below.


Mouse    67 WKTNHAAVPREQVTVINRTTSSVTFTDVV-LPSVQLTCNILSFGQIEQNVYGVTMLSGFPPDKP- 129
            ||...:.....|...:....:|:|....: |.|.:.||  ::..::::......::....|:.| 
  Fly   557 WKDGQSIDFEAQPRFVKTNDNSLTIAKTMELDSGEYTC--VARTRLDEATARANLIV
QDVPNAPK 619

Mouse   130 -TNLTCIVNEGKNMLCQWDPGRETYLETNYTLK-------SEW--ATEKFPDCQSKHGTSCMVSY 184
             |.:||..::.:....|....|...|  :||::       :.|  |.||.|:..|    |.:|..
  Fly   620 LTGITCQADKAEIHWEQQGDNRSPIL--HYTIQFNTSFTPASWDAAYEKVPNTDS----SFVVQM 678

Mouse   185 MPTYYVNIEVWVEAENALG----KVSSES------INFDPVDKV--KPTPPYNL--SVTNSEELS 235
            .|  :.|....|.|.|.:|    ...|:|      :.|...|.|  :.|.|.||  |.|...|:.
  Fly   679 SP--WANYTFRVIAFNKIGASPPSAHSDSCT
TQPDVPFKNPDNVVGQGTEPNNLVISWTPMPEIE 741

Mouse   236 SILK-----LSWVSSGLGGLLDLKSDIQYRTKDASTWIQVPLEDTMSPRTSFTVQDLKPFTEYVF 295
            ....     :||           |.||     .|:.|....:.|..  :.:..:.|...|.:|:.
  Fly   742 HNAPNFHYYVSW-----------KRDI-----PAAAWENNNIFDWR--QNNIVIADQPTFVKYLI 788

Mouse   296 RIRSIKDSGKGYWSDWSEEASGTTYEDRP-SRPPSFWYKTNPSHGQEYRSVRLIWKALPLSEANG 359
            ::.:|.|.|:...:  :||..|.:.|||| ..|.:|..:...|....|    :.|..:......|
  Fly   789 KVVAINDRGESNVA--AEEVVGYSGEDRPLDAPTNFTMRQITSSTSGY----MAWTPVSEESVRG 847

Mouse   360 KILDYEVILTQSKSVSQTYT------------VTGTELTVNLT-----NDRYVASLAARNKVGKS 407
            ....|::         ||:|            |.|......:|     :..|...||...:....
  Fly   848 HFKGYKI---------QTWTENEGEEGLREIHVKGDTHNALVTQFKPDSKNYARILAYNGRFNGP 903

Mouse   408 AAAVLT------IPSPHVTAAYSVVNLKAFP-KDNLLWVEWTPPPKPVSK--------------Y 451
            .:||:.      :|||       |..|.|:| ..:...:.|..|..|..|              |
  Fly   904 PSAVIDFDTPEGVPSP-------VQGLDAYPLGSSAFMLHWKKPLYPNGKLTGYKIYYEEVKESY 961

Mouse   452 ILEWCVLSENAPCVEDWQQEDATVNRTHLRGRLLESKCYQITVTPVFATGPGGSESL-KAYLKQA 515
            :.|   ..|..|.:     .|..|.|..:.|....|| |:|::|.....|.|....: |..||.|
  Fly   962 VGE---RREYDPHI-----TDPRVTRMKMAGLKPNSK-YRISITATTKMGEGSEHYIEKTTLKDA 1017

Mouse   516 ---APARGPTVRTKKVGKNEAVLAWDQIPVDDQNGFIRNYSISYRTSVGKEMVVHVDSSHTEYTL 577
               |||. |:            .:|:|:|.|  || :..:.|::..|.......|.      :|:
  Fly  1018 VNVAPAT-PS------------FSWEQLPSD--NG-LAKFRINWLPSTEGHPGTHF------FTM 1060

Mouse   578 SSLSSDTLYM----VRMAAYTDEGGKDGPEFT-----------FTTPKFAQGEIEAIVV--PV-- 623
            ..:..:|.::    .:.:.|.:.||.| ||..           |.|....| ||:...|  |:  
  Fly  1061 HRIKGETQWIRENEEKNSDYQEVGGLD-PETAYEFRVVSVDGHFNTESATQ-EIDTNTVEGPIMV 1123

Mouse   624 ----------------CLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSKSHIAQWSPHTPPRH 672
                            .|||::  :|.::.|..:|:...|:   :|.|               |.
  Fly  1124 ANETVANAGWFIGMMLALAFII--ILFIIICIIRRNRGGKY---DVHD---------------RE 1168

Mouse   673 NFNSKDQMYSDGNFTDVSVVEIEANNKKPCPDDLKSVDLFKKEKVSTEGHSSGIGGSSCMSSSRP 737
            ..|.:.....:|.|.:.|.           |.|.||.                 |..|..|:::|
  Fly  1169 LANGRRDYPEEGGFHEYSQ-----------PLDNKSA-----------------GRQSVSSANKP 1205

Mouse   738 SISSNEEN-------ESAQSTA-----------------STVQYSTVVHSGYRHQVPSVQVFSRS 778
            .:.|:.::       ::|.:||                 ||.|..   ....:.|....|..|.|
  Fly  1206 GVESDTDSMAEYGDGDTAVATAAARAAAAARSKLTSLPTSTQQQQ---QQQQQQQQQQEQPQSTS 1267

Mouse   779 ESTQPLL 785
            .||.||:
  Fly  1268 ASTVPLI 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Il6stNP_034690.3 Lep_receptor_Ig 26..112 CDD:399379 9/45 (20%)
FN3 125..213 CDD:419708 26/108 (24%)
FN3 220..319 CDD:238020 24/105 (23%)
WSXWS motif 308..312 0/3 (0%)
FN3 521..597 CDD:214495 13/79 (16%)
Box 1 motif 649..657 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 658..678 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 719..754 8/58 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 898..917
NrgNP_001245581.1 Ig 55..128 CDD:299845
IG_like 57..127 CDD:214653
Ig 135..214 CDD:299845
IG_like 141..216 CDD:214653
ig 251..332 CDD:278476
I-set 339..427 CDD:254352
Ig 354..427 CDD:299845
I-set 432..517 CDD:254352
Ig 446..517 CDD:299845
I-set 522..611 CDD:254352 9/55 (16%)
ig 525..609 CDD:278476 9/53 (17%)
FN3 613..707 CDD:238020 26/101 (26%)
FN3 716..807 CDD:238020 25/110 (23%)
fn3 817..905 CDD:278470 16/100 (16%)
FN3 917..1004 CDD:238020 25/102 (25%)
FN3 1041..1111 CDD:238020 14/77 (18%)
Bravo_FIGEY 1155..>1221 CDD:290593 18/111 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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