DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPRED1 and ena

DIOPT Version :10

Sequence 1:XP_005254259.1 Gene:SPRED1 / 161742 HGNCID:20249 Length:456 Species:Homo sapiens
Sequence 2:NP_001137709.1 Gene:ena / 37201 FlyBaseID:FBgn0000578 Length:980 Species:Drosophila melanogaster


Alignment Length:225 Identity:72/225 - (32%)
Similarity:104/225 - (46%) Gaps:47/225 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    21 FFHNSYARVRAVVMTRDDSSGGWLPLG-GSGLSSVTVFKVPHQEENGCADFFIRGERLRDKMVVL 84
            |...|....||.||..||:...|:|.| .||||.|.::.  ||:.|   .|.:.|.:|:|..||:
  Fly   297 FAEQSIIGARASVMVYDDNQKKWVPSGSSSGLSKVQIYH--HQQNN---TFRVVGRKLQDHEVVI 356

Human    85 ECMLKKDLIYNKVTPTFHHWKIDDKKF--GLTFQSPADARAFDRGIRRAIEDIS-------QGCP 140
            .|.:.|.|.||:.|.|||.|:  |.||  ||.|.|..||..|.|.:..|:|.:|       .|.|
  Fly   357 NCSILKGLKYNQATATFHQWR--DSKFVYGLNFSSQNDAENFARAMMHALEVLSGRVANNPGGPP 419

Human   141 ESKNEAEGADDL---QANEEDSS----SSLVKDHL----------FQQETVVTSEP-----YRSS 183
            .:.|..|  :|:   ....||::    ::.:..|:          ..|..:..|.|     :|:|
  Fly   420 TNGNGYE--EDMGYRTMTSEDAAILRQNNSIGGHVTPSAQTPTSQTNQNNIPQSPPTPQGHHRTS 482

Human   184 NIRPSPFEDLNARRVYMQSQANQITFGQPG 213
            :..|:|    ..::...|.||.|:  ||||
  Fly   483 SAPPAP----QPQQQQQQQQAQQM--GQPG 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPRED1XP_005254259.1 EVH1_SPRED-like 25..137 CDD:269978 48/121 (40%)
Sprouty 344..440 CDD:461589
enaNP_001137709.1 EVH1_Ena_VASP-like 301..408 CDD:269918 47/113 (42%)
VASP_tetra 946..979 CDD:462599
Blue background indicates that the domain is not in the aligned region.

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