Protein Alignment SPRED1 and Spred

DIOPT Version :10

• Sequence 1: XP_005254259.1
• Gene: SPRED1 / 161742
• HGNCID: 20249
• Length: 456
• Species: Homo sapiens
• Sequence 2: NP_001260979.1
• Gene: Spred / 36643
• FlyBaseID: FBgn0020767
• Length: 519
• Species: Drosophila melanogaster
• Alignment Length: 484
• Identity: 146/484 - (30%)
• Similarity: 214/484 - (44%)
• Gaps: 106/484 - (21%)

Human    13 QGHDDGICFFHNSYARVRAVVMTRDDSSGGWLPLGGSGLSSVTVFKVPHQEENGCA-DFFIRGER 76
            :||:.      :....|||.|||||:|:.|||||.|.||::|::.|.......... |:.|.|:|
  Fly     3 EGHES------DFLVTVRAQVMTRDESTEGWLPLAGGGLANVSIRKRARLSPLASGHDYIIYGQR 61

Human    77 LRDKMVVLECMLKKDLIYNKVTPTFHHWKIDDKKFGLTFQSPADARAFDRGIRRAIEDISQG--- 138
            :.|:.|:|.|::.:||.|.||.||||||:...::.|||||:.|||||||:|:.||..::..|
  Fly    62 ISDQSVILSCVINRDLKYYKVMPTFHHWRAGKQRNGLTFQTAADARAFDKGVLRAYNELIDGLAK 126

Human   139 ------CPE-SKNEAEGADD--LQANEEDSSSSLVKDHLFQQETVVTSEPYRSSNIRPSPFEDLN 194
                  ||. :|.::.|.||  :..:....|.||.|.|         |.|..|.....|...:.:
  Fly   127 SNPTIICPPLTKYDSVGEDDVFMTLDLPVESESLQKIH---------SSPEGSEKSHKSVSNNSD 182

Human   195 ARRV------YMQSQANQITFGQPGLDIQSRSMEYVQRQISKECGSLKSQNRVPLKSIRHVSFQD 253
            :.::      |:.:.....|...|.....|.:   .....:.:..:.::.:.|.|.::.|
  Fly   183 SEKLPPPPIHYISTDKTSATTSPPDAPPASAA---PSPATAGQIAASENYSYVTLTAVHH----- 239

Human   254 EDEIVRINPRDILIRRYADYRHPDM--------------------WKNDLERDDADSSIQFSKPD 298
                              ||.:|.:                    .:|.||...|.::.|.:...
  Fly   240 ------------------DYNYPVVDQPVGAQVLNARRESISALKKRNALEAAQAMAAAQTAAGG 286

Human   299 SKKSDYLYSC---GDETKLSSPKDSVVFKTQPSSLKIKKSKRRKEDGERSRCVYCQERFNHEENV 360
            .      .:|   |....|..|..|.:.|.:                .|.||.||.|.::.:.|.
  Fly   287 G------LACRDGGSGKPLHKPNVSDILKKE----------------TRLRCRYCHELYSEDFNR 329

Human   361 RGKCQDAPDPIKRCIYQVSCMLCAESMLYHCMSDSEGDFSD-PCSCDTSDDKFCLRWLALVALSF 424
            ||.|:.|||..:.....:|.|.||..|:||||||:||:.:. ||.|..|:.....|||.|..||.
  Fly   330 RGACEYAPDAFRSGYECISGMGCARCMIYHCMSDAEGETAQHPCDCSASEAGCSKRWLGLAILSL 394

Human   425 IVPCMCCYVPLRMCHRCGEACGCCGGKHK 453
            .|||:.||.|||.||..|..||.|||:||
  Fly   395 FVPCLWCYPPLRACHLAGIHCGLCGGQHK 423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPRED1	XP_005254259.1	EVH1_SPRED-like	25..137	CDD:269978	53/112 (47%)
		Sprouty	344..440	CDD:461589	45/96 (47%)
Spred	NP_001260979.1	EVH1_SPRED-like	9..122	CDD:269978	53/112 (47%)
		Sprouty	313..419	CDD:461589	49/105 (47%)