Protein Alignment DAZ1 and hrb1

DIOPT Version :10

• Sequence 1: NP_004072.3
• Gene: DAZ1 / 1617
• HGNCID: 2682
• Length: 744
• Species: Homo sapiens
• Sequence 2: NP_594207.3
• Gene: hrb1 / 2542567
• PomBaseID: SPAC328.05
• Length: 464
• Species: Schizosaccharomyces pombe
• Alignment Length: 479
• Identity: 94/479 - (19%)
• Similarity: 160/479 - (33%)
• Gaps: 143/479 - (29%)

Human    42 VFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGK 106
            |:||.:..::...|:....|:.|:|...:|:....|:|||...:.:....:.:..:
pombe    79 VYVGNLSYQVRWFELKEFMGQVGNVLNCEILNLPNGLSKGCAIIEYSTAEEARTAI--------- 134

Human   107 KLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANP 171
                 ..:..||...|.|                          |::.....|
pombe   135 -----KTLSNQKFMGRLV--------------------------YIREDREQN------------ 156

Human   172 ETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKI 236
                   :|..|:..|.:|:|.|    :.......:|||.:...:...::...|.:.|||....|
pombe   157 -------ARFGSSSVSPSASSNG----KDSEPDRQLFVGNLPYNVRWQDLKDLFRQAGSVIRADI 210

Human   237 ITNRTGVSKGYGFVSFVNDVDVQKIVGSQIH---FHGKKLKLGPAIRKQKLCARHVQPRPLVVNP 298
            ..|:.|.|:|.|.|...:..:....: ..:|   |.|:.|:    :|..:..  |.:.:|...:.
pombe   211 QMNQEGRSRGIGIVVMSSMKEAMHAI-QMLHNTDFMGRTLE----VRLDRFA--HHKSKPYSTHG 268

Human   299 PP---PPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGW 360
            ..   |.:.|..    .:.||| |.:..|...:.:...|.|..|.|
pombe   269 NGYTFPAEMQMT----TSSTYL-PMLGANTQVEDLVYHAYPHGPCS------------------- 309

Human   361 VLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVD--- 422
                     :.::||.:.....:..:...|...|||...:|....||.|||:|.|.|.|:.|
pombe   310 ---------DCIYVGNLPWATSDRNLLDLFTDIGSVIRARIAYEPTGRSKGFGVVQFENENDAAS 365

Human   423 -VQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLV---------VNPPPPPQFQNVWRNPN 477
             ::|:.|  ..:.|:.|:|.        .|.:..|.|.|         |...||     |...|.
pombe   366 SIEKLNG--YRYGGRPLQLS--------YAHYATPLPAVPTVLSGLPSVAYTPP-----VMHIPT 415

Human   478 TETYLQPQITPN------PVTQHV 495
            |.:.|.||...|      |::..|
pombe   416 TNSPLTPQSFTNSFLGYLPISMPV 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAZ1	NP_004072.3	RRM_DAZL	35..116	CDD:410073	12/73 (16%)
		PABP-1234	42..603	CDD:130689	94/479 (20%)
		RRM_DAZL	200..281	CDD:410073	18/83 (22%)
		RRM_DAZL	365..446	CDD:410073	22/84 (26%)
		Daz	596..616	CDD:465893
		Daz	620..640	CDD:465893
		Daz	644..664	CDD:465893
		Daz	668..688	CDD:465893
		Daz	692..712	CDD:465893
hrb1	NP_594207.3	PABP-1234	62..>385	CDD:130689	78/418 (19%)