DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAZ1 and tcg1

DIOPT Version :9

Sequence 1:	NP_004072.3	Gene:	DAZ1 / 1617	HGNCID:	2682	Length:	744	Species:	Homo sapiens
Sequence 2:	NP_595090.2	Gene:	tcg1 / 2541062	PomBaseID:	SPBC660.11	Length:	349	Species:	Schizosaccharomyces pombe

Alignment Length:	314	Identity:	69/314 - (21%)
Similarity:	120/314 - (38%)	Gaps:	76/314 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   155 QITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDET 219
            |..||.|...|:::.:...       .||.:.|:..|.|.        ....||||.:.....::
pombe    10 QNAPNTVQDQVEASVDAAV-------HASAEQSNTPAQQA--------DDFRVFVGRLSTSTKKS 59

Human   220 EIGSCFGRYGSVKEVKIITNRTG-----VSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAI 279
            ||.|.|...|:|::|.|...|..     |..|..||:|.|..||.|.:.:   .:||.|
pombe    60 EIRSLFETVGTVRKVTIPFRRVRRGTRLVPSGIAFVTFNNQEDVDKAIET---LNGKTL------ 115

Human   280 RKQKLCARHVQPRPLVVNPPPPPQFQNV-----WRNPNTETYLQPQITPNPVTQHVQSAANPETP 339
                      ..|.:||....|.|.|.:     .:|.|.|   :|:.:.:.........::.|..
pombe   116 ----------DDREIVVQKARPVQEQPIKDRKKSKNKNGE---EPETSTSVENAESAKGSSDENE 167

Human   340 NSTISREASTQSSSAAASQGWVLPEG--------KIVPNTVFVGGIDARMDETEIGSCFGRYGS- 395
            .:|.:..:|.:::.....|..:..:|        .:.||:::|.|:...:....:...|..|..
pombe   168 ANTATAPSSNEANGVDKKQNEIKGKGGSGKNKAKPLPPNSIYVSGLSVTLTNEGLKEMFDAYNPT 232

Human   396 -------------VKEVKII-TNRTGVSKGYGFVSFVNDVD----VQKIVGSQI 431
                         ::.:|:. ..|.|  :|:|||||.|..|    ::::.|.|:
pombe   233 RARIAVRSLPPYIIRRIKLRGEQRRG--RGFGFVSFANAEDQSRAIEEMNGKQV 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAZ1	NP_004072.3	RRM_DAZL	35..116	CDD:241116
		PABP-1234	42..603	CDD:130689	69/314 (22%)
		RRM_DAZL	200..281	CDD:241116	25/85 (29%)
		RRM_DAZL	365..446	CDD:241116	20/94 (21%)
tcg1	NP_595090.2	RRM_SF	46..124	CDD:302621	28/96 (29%)
tcg1	NP_595090.2	RRM	207..291	CDD:214636	17/80 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910