DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Il12rb2 and Dscam1

DIOPT Version :9

Sequence 1:	NP_032380.1	Gene:	Il12rb2 / 16162	MGIID:	1270861	Length:	874	Species:	Mus musculus
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	908	Identity:	182/908 - (20%)
Similarity:	298/908 - (32%)	Gaps:	257/908 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse    26 DVC----KLGTVT--------VQPAPVI-------PLGSAANISCSLN--PKQGCSHYPSSNELI 69
            |.|    |.||.|        |.|..::       ..||.|.:.|..:  ||.         ::.
  Fly   699 DTCIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFPKP---------QVT 754

Mouse    70 LLKFVNDVLVENLHGKK-----VHDHTGHSSTFQVTNLSLGMTLFVCK-LNCSNSQKKPPVPVCG 128
            ..|.|.|...|....||     |.:.|.|....|.||..    .::|: :|...|...     ..
  Fly   755 WKKAVGDTPGEYKDLKKSDNIRVEEGTLHVDNIQKTNEG----YYLCEAINGIGSGLS-----AV 810

Mouse   129 VEISVGVAPE-------------PPQNISCVQEGENGTVACSWNSGKVTYLKTNYTLQLSGPNNL 180
            :.|||...||             .|..:.|..:||. .:...||.                 ||:
  Fly   811 IMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEK-PIGILWNM-----------------NNM 857

Mouse   181 TCQKQCFSDNRQNCNRLDLGINLSPDLAESR------FIVRVTAINDLGNSSSLPHTFTFLDIVI 239
            ....:  :|||.......|...:...|:..|      .:....|.|..|:..:   :...:...:
  Fly   858 RLDPK--NDNRYTIREEILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDA---SINMIVQEV 917

Mouse   240 PLPPWDIRINFLNASGSRGTLQWED--EGQVVLNQLRYQPLNS-TSWNMVNATNAKG---KYDLR 298
            |..|:.:::  |:.||....|.|..  :|...|::...:...| .||:.::.....|   :..::
  Fly   918 PEMPYALKV--LDKSGRSVQLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQ 980

Mouse   299 DLRPFTEYEFQISSKLHLSGGSWSNWSESLRTRTPEEEPVGILDIWYMKQDIDYD---RQQISLF 360
            .|.|.|.|..:|.:: :..|.|.|  ||::...|.||.|.|      ..|:|..:   :..:.:.
  Fly   981 KLSPATTYNIRIVAE-NAIGTSQS--SEAVTIITAEEAPSG------KPQNIKVEPVNQTTMRVT 1036

Mouse   361 WKSLNPSEARGKILHYQV--------------TLQEVTKK-----TTLQNTTRHTSWTRVIPRTG 406
            ||....:|..|:||.|.|              |:..:|::     ..|||...:|.::.||....
  Fly  1037 WKPPPRTEWNGEILGYYVGYKLSNTNSSYVFETINFITEEGKEHNLELQNLRVYTQYSVVIQAFN 1101

Mouse   407 AWTASVSAANSKGASAPTHINIVDLCGTGLLAPHQVSAKSENMDNILVTW-QPP-KKADSAVREY 469
            ...|...:...|..:|.         ||....|...:..:.....|.|.| .|| :.|:..::.|
  Fly  1102 KIGAGPLSEEEKQFTAE---------GTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTY 1157

Mouse   470 IV------EWRALQPGSITKFPPHWLRIPPDNMSALISENIKPYICYEIRVHALSESQGGCSS-- 526
            .|      ||       ..:...|:.:..   .|..:...:|.|..|.::|.|.:....|..|
  Fly  1158 KVVYAPSDEW-------YDETKRHYKKTA---SSDTVLHGLKKYTNYTMQVLATTAGGDGVRSVP 1212

Mouse   527 IRGDSKHKAPVSGPHITAITEKKERLFISWTHIPFPEQRGCILHYRIYWKERDSTAQPELCEIQY 591
            |...::...|.:...:.|:......:.:||.  |..:..|.|..|.:|.|...:..:.:..::.:
  Fly  1213 IHCQTEPDVPEAPTDVKALVMGNAAILVSWR--PPAQPNGIITQYTVYSKAEGAETETKTQKVPH 1275

Mouse   592 RRSQNSHPISSLQPRVTYVLWMTAVTAAGESPQGNEREFCPQGKANWKAFVISSICIAIITVGTF 656
              .|.|...:.|:....|..|:||.|..||..|.......|..:...|   |:|.      ..||
  Fly  1276 --YQMSFEATELEKNKPYEFWVTASTTIGEGQQSKSIVAMPSDQVPAK---IASF------DDTF 1329

Mouse   657 SIRYFRQKAFTLLSTLKPQ----WYSRTIPDPANSTWVKKYPILEEKIQLPTDNLLMAWPTPEEP 717
            :..:........|:...||    |..:.:...||          :....||..:||:.
  Fly  1330 TATFKEDAKMPCLAVGAPQPEITWKIKGVEFSAN----------DRMRVLPDGSLLIK------- 1377

Mouse   718 EPLIIHEVLYHMIPVVRQPYYFKRGQGFQGYSTSKQDA----MYIANPQATGTLTAETRQLVNLY 778
                                           |.::|||    .:..|..|..::|         :
  Fly  1378 -------------------------------SVNRQDAGDYSCHAENSIAKDSIT---------H 1402

Mouse   779 KVLESRDPDSK----LANLTSPLTVTPVNYLPSHEGYLPSNIEDLSPHEAD--PTDSFDLEHQ 835
            |::....|.|.    .|..|..|||                  .|.|||.|  |...:.|.::
  Fly  1403 KLIVLAPPQSPHVTLSATTTDALTV------------------KLKPHEGDTAPLHGYTLHYK 1447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Il12rb2	NP_032380.1	Lep_receptor_Ig	28..120	CDD:368845	28/118 (24%)
		FN3	240..332	CDD:238020	23/97 (24%)
		WSXWS motif	321..325		1/3 (33%)
		fn3	438..523	CDD:365830	18/92 (20%)
		FN3	536..630	CDD:238020	21/93 (23%)
		Box 1 motif	677..685		0/7 (0%)
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165	6/14 (43%)
		IGc2	735..804	CDD:197706	20/81 (25%)
		I-set	819..914	CDD:254352	19/117 (16%)
		Ig	833..921	CDD:299845	18/110 (16%)
		FN3	918..1011	CDD:238020	23/97 (24%)
		FN3	1018..1116	CDD:238020	21/103 (20%)
		FN3	1124..1217	CDD:238020	21/102 (21%)
		FN3	1222..1312	CDD:238020	21/93 (23%)
		Ig	1339..1406	CDD:299845	18/123 (15%)
		FN3	1409..1499	CDD:238020	14/57 (25%)
		FN3	1504..1584	CDD:238020
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910