DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MDGA2 and Sr-CI

DIOPT Version :9

Sequence 1:	NP_001106970.4	Gene:	MDGA2 / 161357	HGNCID:	19835	Length:	1025	Species:	Homo sapiens
Sequence 2:	NP_001285599.1	Gene:	Sr-CI / 33621	FlyBaseID:	FBgn0014033	Length:	629	Species:	Drosophila melanogaster

Alignment Length:	307	Identity:	81/307 - (26%)
Similarity:	128/307 - (41%)	Gaps:	53/307 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   722 YSLQWTQMNP-DAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLT---ELIKPEAY 782
            |:||.|.|.. |...|:...:......|..|..:.|   ||:::       ||:   :::..:.|
  Fly    49 YTLQGTVMQTCDRDGRLRGEKPFCASRGCARPEDPE---NGHVE-------NLSLRADVVCHDGY 103

Human   783 EVRLTPLTKFGEGDSTIRVIKYSAPV-----NPHLREFHCGFEDGNICLFTQDDTDNFDWTKQST 842
             |.:...|.:.:|:      ::|..:     :.|.|:..|.||..:.|.:..:.|....|.:.||
  Fly   104 -VLVGGRTAYCDGE------RWSTQLGSCRRSNHTRDHSCDFESEDQCGWEAETTFRRPWKRVST 161

Human   843 ATRNTKYTPNTGPNADRSGSKE--GFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPT-NTAY 904
            .  :..::..|||..|.:...|  |.||.:||.....  ....||||::      |...| .||.
  Fly   162 V--SDIHSLRTGPRHDHTFKNESGGHYMRMETQMGAY--GSYHLLSPIY------PRSLTLKTAC 216

Human   905 CFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSS----------SGNKGQRWNEAHVNIYPI-T 958
            ||.|.|.|:|  .||.|:.:.:|..:.....:|:.          ||.:|.:|.|..::|..: .
  Fly   217 CFRFHYFMFG--AGVDNLVVSVKPVSMPMATMWNRFRANCSKFEISGQQGTQWLEHTISIDEMQE 279

Human   959 SFQLIFEGIRGPGIEGDIAIDDVSIAEG-ECAKQDLATKNSVDGAVG 1004
            .||:||.........||||||||.:..| ||.....:|........|
  Fly   280 DFQVIFTATDARSQFGDIAIDDVKLMTGSECGTNGFSTTTEPTAPTG 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MDGA2	NP_001106970.4	IG	117..197	CDD:214652
		Ig_3	203..288	CDD:404760
		Ig strand B	224..228	CDD:409353
		Ig strand C	237..241	CDD:409353
		Ig strand E	268..272	CDD:409353
		Ig strand F	282..287	CDD:409353
		Ig strand A	313..317	CDD:409353
		IGc2	325..386	CDD:197706
		Ig strand B	327..337	CDD:409353
		Ig strand C	343..347	CDD:409353
		Ig strand C'	349..351	CDD:409353
		Ig strand D	356..361	CDD:409353
		Ig strand E	362..368	CDD:409353
		Ig strand F	375..383	CDD:409353
		Ig	418..493	CDD:416386
		Ig strand B	424..428	CDD:409353
		Ig strand C	439..443	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	483..488	CDD:409353
		Ig strand G	497..500	CDD:409353
		Ig_3	510..587	CDD:404760
		Ig strand A	511..514	CDD:409353
		Ig strand A'	519..524	CDD:409353
		Ig strand B	530..537	CDD:409353
		Ig strand C	543..548	CDD:409353
		Ig strand C'	550..552	CDD:409353
		Ig strand D	560..563	CDD:409353
		Ig strand E	567..573	CDD:409353
		Ig strand F	580..587	CDD:409353
		MAM	817..989	CDD:395504	57/186 (31%)
Sr-CI	NP_001285599.1	CCP	22..72	CDD:214478	7/22 (32%)
		CCP	77..125	CDD:214478	11/64 (17%)
		MAM	131..308	CDD:214533	56/188 (30%)
		MAM	136..308	CDD:99706	55/183 (30%)
		Somatomedin_B	335..385	CDD:295334
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9778
eggNOG	1	0.900	-	-		E1_2CMY0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810