DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAPK3 and sqa

DIOPT Version :9

Sequence 1:	NP_001339.1	Gene:	DAPK3 / 1613	HGNCID:	2676	Length:	454	Species:	Homo sapiens
Sequence 2:	NP_001260832.1	Gene:	sqa / 36002	FlyBaseID:	FBgn0259678	Length:	888	Species:	Drosophila melanogaster

Alignment Length:	411	Identity:	137/411 - (33%)
Similarity:	209/411 - (50%)	Gaps:	68/411 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     5 RQEDVEDHYEMGEELGSGQFAIVRKCRQKGTGKEYAAKF--IKKRRLSSSRRGVSREEIEREVNI 67
            |..|...||::..|:|.|:|..|.|||.|..|.:.||||  |.||.        .:..:||||.|
  Fly    26 RNVDAHKHYDVLGEVGRGKFGTVYKCRDKANGLQLAAKFVPIPKRE--------DKRNVEREVEI 82

Human    68 LREIRHPNIITLHDIFENKTDVVLILELVSGGELFDFLAEKE-SLTEDEATQFLKQILDGVHYLH 131
            :..::|..||.|:..:|.:..:.::|||:.||||||.:.:.| .|||.....|::|:.:.:.::|
  Fly    83 MNSLQHHLIIQLYAAYEYQKMMCVVLELIEGGELFDRVVDDEFVLTERVCRVFIRQVCEAMAFIH 147

Human   132 SKRIAHFDLKPENIMLLDKNVPNPRIKLIDFGIAHKIEAGNEFKNIFGTPEFVAPEIVNYEPLGL 196
            ...|.|.|||||||::|.:.  ..|||:||||:|.|.:.....:.:||||||||||:||::.:..
  Fly   148 GNGIVHLDLKPENILVLTQK--GNRIKIIDFGLARKFDPDKRLRVLFGTPEFVAPEVVNFDCISY 210

Human   197 EADMWSIGVITYILLSGASPFLGETKQETLTNISAVNYDFDEEYFSNTSELAKDFIRRLLVKDPK 261
            ..||||:|||.|:|:||.|||:||...||::|::...|||::|.|:..|....|||.:||.||..
  Fly   211 GTDMWSVGVICYVLISGLSPFMGENDIETMSNVTIAKYDFEDECFNGISPECLDFIAKLLAKDLS 275

Human   262 RRMTIAQSLEHSWIKAIRRRNVRGEDSGRKPERRRLKTTRLKEYTIKSHSSLPPNNSYADFERFS 326
            .|||.|:.::|.|::             ::|......|...|..:..|.|.|         :..|
  Fly   276 TRMTAAECMKHKWLQ-------------QRPATAATATPITKAASAASKSRL---------KSVS 318

Human   327 KVLEEAAAAEEGLRELQRSRRLCHEDVEALAAIYEEKEAWYREESDSLGQDLRRLRQELLKTEAL 391
            .|...:.::|:....::      .||.|...|:.:.|:
  Fly   319 PVTAPSESSEDSTETIE------DEDDEEEVAVQQAKQ--------------------------- 350

Human   392 KRQAQEEAKGALLGTSGLKRR 412
            |.|.|:|....|.|.:.|:.:
  Fly   351 KDQQQDEELANLCGDAELENK 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAPK3	NP_001339.1	STKc_DAPK	7..275	CDD:271007	114/270 (42%)
		Activation segment. /evidence=ECO:0000250\|UniProtKB:O96017	161..204		21/42 (50%)
		Leucine-zipper. /evidence=ECO:0000303\|PubMed:9488481	427..441
sqa	NP_001260832.1	S_TKc	34..289	CDD:214567	112/264 (42%)
sqa	NP_001260832.1	STKc_MLCK	40..289	CDD:271005	110/258 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810