DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAPK1 and dapk1

DIOPT Version :9

Sequence 1:	NP_001275658.1	Gene:	DAPK1 / 1612	HGNCID:	2674	Length:	1430	Species:	Homo sapiens
Sequence 2:	NP_001093460.1	Gene:	dapk1 / 558314	ZFINID:	ZDB-GENE-060526-177	Length:	1439	Species:	Danio rerio

Alignment Length:	1442	Identity:	1074/1442 - (74%)
Similarity:	1254/1442 - (86%)	Gaps:	15/1442 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
            ||||.||||:|||:.|.||||||||||||||.||||::||||||||||:||||||||::||||||
Zfish     1 MTVFNQENVEDYYEIGGELGSGQFAVVKKCRHKSTGVEYAAKFIKKRRSKSSRRGVSKDDIEREV 65

Human    66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
            |||||||||||||||:|:|||.:|||||||||||||||||||||||:||||||||||||:||.||
Zfish    66 SILKEIQHPNVITLHDVFENKHEVILILELVAGGELFDFLAEKESLSEEEATEFLKQILDGVSYL 130

Human   131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 195
            ||.:|:||||||||||||:||||.||||:|||||||||||||:||||||||||||||:|||||||
Zfish   131 HSKRISHFDLKPENIMLLNRNVPHPRIKLIDFGLAHKIDFGNDFKNIFGTPEFVAPEVVNYEPLG 195

Human   196 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDP 260
            ||||||||||||||||||||||||:.|||||||||||:|||:::|||:|||||||||.|||:|||
Zfish   196 LEADMWSIGVITYILLSGASPFLGENKQETLANVSAVDYEFDEDYFSHTSALAKDFIARLLIKDP 260

Human   261 KKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSR 325
            ||||||.||||||||||||||||||||.||||||||||||||:||||||||||||.|||||||||
Zfish   261 KKRMTILDSLQHPWIKPKDTQQALSRKESAVNMEKFKKFAARRKWKQSVRLISLCNRLSRSFLSR 325

Human   326 SNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCG 390
            |||||||||||||||||||||||||||||||||||:||||||::||:||||||||||||||||||
Zfish   326 SNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLKHLLGSLTSYDINQPNKHGTPPLLIAAGCG 390

Human   391 NIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARY 455
            |:||:.:|:|:|:.|...||.|::|:|:|||||||.||:||.|.|||||::|||||.||||||||
Zfish   391 NVQIIDVLMKKGAEIQAFDKTGASAIYYAARHGHVGTLRFLHEKKCPLDIQDKSGETALHVAARY 455

Human   456 GHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
            |:.||.|.|||..:||::.|:|:||||||||||||.:||:|||||||:||.:|||||:|||||||
Zfish   456 GNVDVVQYLCSIHANPDLLDREQETPLHCAAWHGYSAVARALCEAGCDVNARNREGESPLLTASA 520

Human   521 RGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC 585
            ||:.||||||.|||||:::.||||||||||||||||:||:|.|||..|:||:||||||||||:||
Zfish   521 RGFKDIVECLLEHGADMDSADKDGHIALHLAVRRCQVEVVKCLLSHHCYVDHQDRHGNTPLHIAC 585

Human   586 KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
            ||.|||:|..||.|..||||.||:|||||||||:||.|:|||:|||.||:.||:|.|||||||||
Zfish   586 KDANMPVVTQLCAAKANLDIPNKFGRTPLHLAASNGGLEVVRHLCLSGANTEAITNDGKTAEDLA 650

Human   651 RSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSF 715
            .:||.||||.|||:|:||.|:.::||||||||.||.|:|||||||||:||:|||||||||:||||
Zfish   651 TAEQQEHVAVLLAKLKKDNHKSIYIQQLRPTQTLQHRLKLKLFGHSGAGKSTLVESLKCGILRSF 715

Human   716 FRRRRPRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP 780
            |||||.||  ||..|.|.||:.|||.|||||:||||||||||||||||||||.||||:|||| :|
Zfish   716 FRRRRTRL--TNPVRHPASPVTSKPAVSVSISNLYPGCENVSVRSRSMMFEPSLTKGVLEVF-SP 777

Human   781 THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVFSLEEP 845
            .|:...:|||.:|||||||||.:|||||||:|||||||||:|.||||||||.|:||:|:||||||
Zfish   778 VHNALSTADDTATKAIDIQNANVNGVGDFSIWEFSGNPVYYCSYDYFAANDATAIHLVLFSLEEP 842

Human   846 YEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGGEFGYDKDTSL 910
            ||.|||||.|||:.||:|...|:.||||||::|||:||||||||||:|:||..||||.|||:.||
Zfish   843 YETQLNQVTFWLNCLKALTLPEDNIAFGGKIRNPLRVVLVATHADIVNLPRSFGGEFSYDKERSL 907

Human   911 LKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCPPMTHLCEKIISTLPS 975
            |||:||||||||.|:.||||:|||||.|||:|:|||.|.|:||.|:|.|.|||.|.||::|||||
Zfish   908 LKEVRNRFGNDLLITEKLFVMDAGASNSKDIKLLRNLLFELRSTIISTCRPMTQLAEKLLSTLPS 972

Human   976 WRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGEINIMQSETVQDVLLLDPRWL 1040
            ||||||||||:|.||||.|||:|:||||||||||.:|.||||.||||||||||||||:|||||||
Zfish   973 WRKLNGPNQLISWQQFVVDVQEQINPLASEEDLRGLASQLHSMGEINIMQSETVQDVVLLDPRWL 1037

Human  1041 CTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEELLQILDAMDICARDLSSGTMVDVPA 1105
            |:||||||||:|||:|:|||||||.||::|.||.:.|::||||:|||||:|||||::..|||:||
Zfish  1038 CSNVLGKLLSIETPKAIHHYRGRYRVEELQHLVSEGDIDELLQVLDAMDVCARDLANPGMVDIPA 1102

Human  1106 LIKTDNLHRSWADEED----EVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQSTEGDA- 1165
            ||:|..|..:|.||||    :.::|||||:||||||.|||||:|||:|||||||..||..|.:|
Zfish  1103 LIRTGGLQHTWTDEEDVEGEDALLYGGVRMVPVEHLAPFPCGLFHKLQVNLCRWSRQQKPEVEAD 1167

Human  1166 DIRLWVNGCKLANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIENVMATTLPGL 1230
            |:|||..|.::...|.|.||||||||||:|||:||.:|:..:|..|||::|...|.::|.|||||
Zfish  1168 DVRLWSGGARIGLGGVEALVLLVNHGQGMEVQLRGPDTDPGRCYALLDTLCGMAEGLLAATLPGL 1232

Human  1231 LTVKHYLSPQQLREHHEPVMIYQPRDFFRAQTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQAS 1295
            ||.:||||||||||||.|||:||||||||||...|.:|:||||||:|||.||:..||..||.|.:
Zfish  1233 LTARHYLSPQQLREHHGPVMLYQPRDFFRAQARGENALSNTMGGYRESFVSIVALGCIHVYKQGN 1297

Human  1296 LGMDIHASDLNLLTRRKLSRLLDPPDPLGKDWCLLAMNLGLPDLVAKYNTS-NGAPKD---FLPS 1356
            ||.::..::::||.||||.|||||||.||||||||||||||.:|.|||::. ||.|..   .|||
Zfish  1298 LGGEVAVAEVSLLARRKLCRLLDPPDALGKDWCLLAMNLGLSELAAKYSSGINGTPPADPLSLPS 1362

Human  1357 PLHALLREWTTYPESTVGTLMSKLRELGRRDAADFLLKASSVFKINLD--GNGQEAYASSCN-SG 1418
            |...||:||:..|:||:|.|::|||||||||||||||:|:.||::||:  |...|.|:..|| .|
Zfish  1363 PTATLLQEWSQRPDSTIGVLVAKLRELGRRDAADFLLRAAPVFRVNLEILGTPSEPYSPVCNGGG 1427

Human  1419 TSYNSISSVVSR 1430
            |||||||||:||
Zfish  1428 TSYNSISSVISR 1439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAPK1	NP_001275658.1	STKc_DAPK1	7..275	CDD:271096	232/267 (87%)
		Calmodulin-binding	267..334		62/66 (94%)
		Autoinhibitory domain. /evidence=ECO:0000250	292..301		8/8 (100%)
		ANK	373..497	CDD:238125	85/123 (69%)
		ANK repeat	378..409	CDD:293786	20/30 (67%)
		ANK 1	378..407		20/28 (71%)
		ANK 2	411..440		19/28 (68%)
		ANK repeat	412..442	CDD:293786	20/29 (69%)
		ANK	439..564	CDD:238125	92/124 (74%)
		ANK repeat	444..475	CDD:293786	20/30 (67%)
		ANK 3	444..473		20/28 (71%)
		ANK repeat	477..508	CDD:293786	24/30 (80%)
		ANK 4	477..506		23/28 (82%)
		ANK	505..629	CDD:238125	93/123 (76%)
		ANK repeat	510..541	CDD:293786	23/30 (77%)
		ANK 5	510..539		23/28 (82%)
		Ank_2	<515..768	CDD:330894	191/252 (76%)
		ANK repeat	543..574	CDD:293786	23/30 (77%)
		ANK 6	543..572		22/28 (79%)
		ANK repeat	576..607	CDD:293786	22/30 (73%)
		ANK 7	576..605		20/28 (71%)
		ANK repeat	609..638	CDD:293786	20/28 (71%)
		ANK 8	609..638		20/28 (71%)
		ANK 9	875..904		21/28 (75%)
		ANK 10	1162..1196		19/34 (56%)
		Death_DAPK1	1308..1393	CDD:260052	59/88 (67%)
dapk1	NP_001093460.1	STKc_DAPK1	7..275	CDD:271096	232/267 (87%)
		S_TKc	13..275	CDD:214567	227/261 (87%)
		Ank_2	<337..409	CDD:289560	57/71 (80%)
		ANK	373..497	CDD:238125	85/123 (69%)
		ANK repeat	378..409	CDD:293786	20/30 (67%)
		Ank_4	379..432	CDD:290365	34/52 (65%)
		ANK repeat	412..442	CDD:293786	20/29 (69%)
		Ank_2	416..508	CDD:289560	65/91 (71%)
		ANK	439..564	CDD:238125	92/124 (74%)
		ANK repeat	444..475	CDD:293786	20/30 (67%)
		ANK repeat	477..508	CDD:293786	24/30 (80%)
		ANK	505..629	CDD:238125	93/123 (76%)
		ANK repeat	510..541	CDD:293786	23/30 (77%)
		Ank_4	513..564	CDD:290365	39/50 (78%)
		ANK repeat	543..574	CDD:293786	23/30 (77%)
		Ank_2	548..635	CDD:289560	64/86 (74%)
		ANK repeat	576..607	CDD:293786	22/30 (73%)
		ANK	604..>671	CDD:238125	48/66 (73%)
		ANK repeat	609..638	CDD:293786	20/28 (71%)
		Ank_4	610..662	CDD:290365	38/51 (75%)
		Death_DAPK1	1310..1399	CDD:260052	59/88 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194330104
Domainoid	1	1.000	965	1.000	Domainoid score	I471
eggNOG	1	0.900	-	-		E1_KOG0032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3626
Inparanoid	1	1.050	2176	1.000	Inparanoid score	I365
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46637
OrthoDB	1	1.010	-	-		D23404at7742
OrthoFinder	1	1.000	-	-		FOG0009189
OrthoInspector	1	1.000	-	-		oto50217
orthoMCL	1	0.900	-	-		OOG6_105243
Panther	1	1.100	-	-	LDO	PTHR24342
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2473
SonicParanoid	1	1.000	-	-		X6927
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300