DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DAPK1 and CaMKI

DIOPT Version :9

Sequence 1:NP_001275658.1 Gene:DAPK1 / 1612 HGNCID:2674 Length:1430 Species:Homo sapiens
Sequence 2:NP_524622.1 Gene:CaMKI / 43792 FlyBaseID:FBgn0016126 Length:405 Species:Drosophila melanogaster


Alignment Length:392 Identity:131/392 - (33%)
Similarity:201/392 - (51%) Gaps:34/392 - (8%)


- Green bases have known domain annotations that are detailed below.


Human     5 RQENVDDYYDTGEELGSGQFAVVKKCREK-STGLQYAAKFIKKRRTKSSRRGVSREDIEREVSIL 68
            :|.::::.|:....||:|.|:.|:....| |.|..:|.|.|.|:..|.     ..|.:|.|:.:|
  Fly    23 KQVSIEEKYNLHGLLGTGAFSEVRLAESKDSPGEHFAVKIIDKKALKG-----KEESLENEIRVL 82

Human    69 K---------------EIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATE 118
            :               .:.|||::.|.|.||:|:.|.|::|||.||||||.:.||.|.||::|:.
  Fly    83 RRFSANHFDGKCLNGTRLTHPNIVQLLETYEDKSKVYLVMELVTGGELFDRIVEKGSYTEKDASH 147

Human   119 FLKQILNGVYYLHSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEF 183
            .::|||..|.|:|...:.|.||||||::....: ...:|.|.||||: |::.........|||.:
  Fly   148 LIRQILEAVDYMHEQGVVHRDLKPENLLYYSPD-DDSKIMISDFGLS-KMEDSGIMATACGTPGY 210

Human   184 VAPEIVNYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALA 248
            ||||::..:|.|...|:||||||:||||.|..||..:......|.:...::||:..|:...|..|
  Fly   211 VAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDENDANLFAQILKGDFEFDSPYWDEISESA 275

Human   249 KDFIRRLLVKDPKKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLIS 313
            |.||:.|:....:||.|.:.:|.|.||   ...:|.||.......|:.||..|:.:|||:....:
  Fly   276 KHFIKNLMCVTVEKRYTCKQALGHAWI---SGNEASSRNIHGTVSEQLKKNFAKSRWKQAYYAAT 337

Human   314 LCQRLSRSFL-SRSNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNK 377
            :.:::.|..| |.||.:...|:.:  .:||....|...|.. .||...|..:.|    ...:.||
  Fly   338 VIRQMQRMALNSNSNANFDSSNSS--NQDSTTPTAATGAWT-SNVLSSQQSVQS----HAQEMNK 395

Human   378 HG 379
            .|
  Fly   396 SG 397

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DAPK1NP_001275658.1 STKc_DAPK1 7..275 CDD:271096 101/283 (36%)
Calmodulin-binding 267..334 19/67 (28%)
Autoinhibitory domain. /evidence=ECO:0000250 292..301 3/8 (38%)
ANK 373..497 CDD:238125 3/7 (43%)
ANK repeat 378..409 CDD:293786 1/2 (50%)
ANK 1 378..407 1/2 (50%)
ANK 2 411..440
ANK repeat 412..442 CDD:293786
ANK 439..564 CDD:238125
ANK repeat 444..475 CDD:293786
ANK 3 444..473
ANK repeat 477..508 CDD:293786
ANK 4 477..506
ANK 505..629 CDD:238125
ANK repeat 510..541 CDD:293786
ANK 5 510..539
Ank_2 <515..768 CDD:330894
ANK repeat 543..574 CDD:293786
ANK 6 543..572
ANK repeat 576..607 CDD:293786
ANK 7 576..605
ANK repeat 609..638 CDD:293786
ANK 8 609..638
ANK 9 875..904
ANK 10 1162..1196
Death_DAPK1 1308..1393 CDD:260052
CaMKINP_524622.1 STKc_CaMKI 27..301 CDD:270985 101/280 (36%)
S_TKc 31..302 CDD:214567 101/277 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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