DRSC/TRiP Functional Genomics Resources

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Protein Alignment DAPK1 and Strn-Mlck

DIOPT Version :10

Sequence 1:NP_004929.2 Gene:DAPK1 / 1612 HGNCID:2674 Length:1430 Species:Homo sapiens
Sequence 2:NP_001261019.1 Gene:Strn-Mlck / 36753 FlyBaseID:FBgn0265045 Length:8255 Species:Drosophila melanogaster


Alignment Length:423 Identity:146/423 - (34%)
Similarity:226/423 - (53%) Gaps:67/423 - (15%)


- Green bases have known domain annotations that are detailed below.


Human    17 EELGSGQFAVVKKCREKSTGLQ-YAAKFIKKRRTKSSRRGVSREDIEREVSILKEIQHPNVITLH 80
            ||||.|:|.:|.|.:|:....| .|||.||..:::      .|:.:..|:||::.:|||.::.|.
  Fly  7624 EELGKGRFGIVYKVQERGQPEQLLAAKVIKCIKSQ------DRQKVLEEISIMRALQHPKLLQLA 7682

Human    81 EVYENKTDVILILELVAGGELFD-FLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPEN 144
            ..:|:..::::::|.:.|||||: .:|:..:|||.:...||:|:.:||.|:|...:.|.||||||
  Fly  7683 ASFESPREIVMVMEYITGGELFERVVADDFTLTEMDCILFLRQVCDGVAYMHGQSVVHLDLKPEN 7747

Human   145 IMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMWSIGVITYI 209
            ||...|.  ..:|||||||||.::|.....:.:||||||:.|||::|||:|.::||||:|||.|:
  Fly  7748 IMCHTRT--SHQIKIIDFGLAQRLDTKAPVRVLFGTPEFIPPEIISYEPIGFQSDMWSVGVICYV 7810

Human   210 LLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDPKKRMTIQDSLQHPW 274
            ||||.|||:|||..||.:|::..:|:::||.|...|..|||||.:|||...:.|:|.|..|...|
  Fly  7811 LLSGLSPFMGDTDVETFSNITRADYDYDDEAFDCVSQEAKDFISQLLVHRKEDRLTAQQCLASKW 7875

Human   275 I--KPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSRSNMSVA------ 331
            :  :|.|     |...:.:..:|.|||..|:||:::...|....|::...:||.|.::|      
  Fly  7876 LSQRPDD-----SLSNNKICTDKLKKFIIRRKWQKTGNAIRALGRMANLSVSRRNSAIAMGVLSS 7935

Human   332 ----------------------RSDDTLDEEDSF------VMKAIIHAIND-------------- 354
                                  :.....:|||.|      |.|..:..:.|              
  Fly  7936 PRPSISGLGMLTTSAIGSGTSSQMTSLHEEEDDFSGEMPPVEKRTVLKLRDKSQCSERSDSGYSE 8000

Human   355 -DNVPGLQH-LLGSLSNYDVNQPNKHGTPPLLI 385
             .|..|.|. ||.||:...:....|..|.|.::
  Fly  8001 CSNCSGAQETLLLSLAKSKLEAIAKASTLPTVV 8033

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DAPK1NP_004929.2 STKc_DAPK1 7..275 CDD:271096 112/259 (43%)
Calmodulin-binding 267..334 19/96 (20%)
Autoinhibitory domain. /evidence=ECO:0000250 292..301 4/8 (50%)
Ank_2 <338..409 CDD:463710 17/70 (24%)
ANK repeat 378..409 CDD:293786 2/8 (25%)
ANK 1 378..407 2/8 (25%)
ANKYR 392..668 CDD:440430
ANK 2 411..440
ANK repeat 412..442 CDD:293786
ANK repeat 444..475 CDD:293786
ANK 3 444..473
ANK repeat 477..508 CDD:293786
ANK 4 477..506
ANK repeat 510..541 CDD:293786
ANK 5 510..539
ANK repeat 543..574 CDD:293786
ANK 6 543..572
ANK repeat 576..607 CDD:293786
ANK 7 576..605
ANK repeat 609..638 CDD:293786
ANK 8 609..638
ANK 9 875..904
ANK 10 1162..1196
Death_DAPK1 1308..1393 CDD:260052
Strn-MlckNP_001261019.1 Ig_3 26..112 CDD:464046
Ig <70..112 CDD:472250
Ig strand E 92..96 CDD:409353
Ig strand F 106..111 CDD:409353
Ig 137..226 CDD:472250
Ig strand B 154..158 CDD:409353
Ig strand C 167..171 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 219..222 CDD:409353
Ig 235..314 CDD:472250
Ig strand B 251..255 CDD:409564
Ig strand C 264..268 CDD:409564
Ig strand E 280..284 CDD:409564
Ig strand F 294..299 CDD:409564
Ig strand G 307..310 CDD:409564
Ig_3 336..414 CDD:464046
Ig 438..513 CDD:472250
Ig strand B 454..458 CDD:409564
Ig strand C 467..471 CDD:409564
Ig strand E 483..487 CDD:409564
Ig strand F 493..498 CDD:409564
Ig strand G 506..509 CDD:409564
Ig 537..628 CDD:472250
Ig strand B 554..558 CDD:409353
Ig strand C 567..571 CDD:409353
Ig strand F 607..612 CDD:409353
Ig strand G 620..623 CDD:409353
Ig 636..713 CDD:472250
Ig strand B 652..656 CDD:409564
Ig strand C 665..669 CDD:409564
Ig strand E 681..685 CDD:409564
Ig strand F 695..700 CDD:409564
Ig strand G 708..711 CDD:409564
SMC_N <2131..2664 CDD:481474
PTZ00121 <2600..3256 CDD:173412
PTZ00121 <3635..4609 CDD:173412
PTZ00121 <4215..5072 CDD:173412
I-set 5300..5388 CDD:400151
Ig strand B 5317..5321 CDD:409353
Ig strand C 5329..5333 CDD:409353
Ig strand E 5354..5358 CDD:409353
Ig strand F 5368..5373 CDD:409353
Ig_3 5399..5477 CDD:464046
Ig 5542..5627 CDD:472250
Ig strand B 5556..5560 CDD:409353
Ig strand C 5568..5572 CDD:409353
Ig strand E 5593..5597 CDD:409353
Ig strand F 5607..5612 CDD:409353
Ig 5654..5721 CDD:409353
Ig strand B 5654..5658 CDD:409353
Ig strand C 5665..5669 CDD:409353
Ig strand E 5690..5694 CDD:409353
Ig strand F 5704..5709 CDD:409353
Ig strand G 5718..5721 CDD:409353
I-set 5784..5874 CDD:400151
Ig strand B 5801..5805 CDD:409353
Ig strand C 5814..5818 CDD:409353
Ig strand E 5840..5844 CDD:409353
Ig strand F 5854..5859 CDD:409353
Ig 5902..5963 CDD:409353
Ig strand B 5902..5906 CDD:409353
Ig strand C 5915..5919 CDD:409353
Ig strand E 5941..5945 CDD:409353
Ig strand F 5955..5960 CDD:409353
Ig 5997..6086 CDD:472250
Ig strand B 6014..6018 CDD:409353
Ig strand C 6028..6032 CDD:409353
Ig strand E 6050..6056 CDD:409353
Ig strand F 6066..6071 CDD:409353
Ig strand G 6079..6082 CDD:409353
Ig 6107..6187 CDD:472250
Ig strand B 6115..6119 CDD:409353
Ig strand C 6128..6132 CDD:409353
Ig strand E 6153..6157 CDD:409353
Ig strand F 6167..6172 CDD:409353
Ig strand G 6180..6183 CDD:409353
FN3 6216..6310 CDD:238020
I-set 6321..6412 CDD:400151
Ig strand B 6339..6343 CDD:409353
Ig strand C 6352..6356 CDD:409353
Ig strand E 6375..6382 CDD:409353
Ig strand F 6392..6397 CDD:409353
Ig strand G 6405..6408 CDD:409353
I-set 6442..6531 CDD:400151
Ig strand B 6459..6463 CDD:409353
Ig strand C 6472..6476 CDD:409353
Ig strand E 6497..6501 CDD:409353
Ig strand F 6511..6516 CDD:409353
Ig strand G 6524..6527 CDD:409353
Ig 6541..6632 CDD:472250
Ig strand B 6559..6563 CDD:409353
Ig strand C 6572..6576 CDD:409353
Ig strand E 6598..6602 CDD:409353
Ig strand F 6612..6617 CDD:409353
Ig strand G 6625..6628 CDD:409353
Ig 6662..6754 CDD:472250
Ig strand B 6679..6683 CDD:409353
Ig strand C 6692..6696 CDD:409353
Ig strand E 6720..6724 CDD:409353
Ig strand F 6734..6739 CDD:409353
I-set 6779..6868 CDD:400151
Ig strand B 6796..6800 CDD:409353
Ig strand C 6809..6813 CDD:409353
Ig strand E 6834..6838 CDD:409353
Ig strand F 6848..6853 CDD:409353
I-set 6939..7028 CDD:400151
Ig strand B 6956..6960 CDD:409353
Ig strand C 6969..6973 CDD:409353
Ig strand E 6993..6998 CDD:409353
Ig strand F 7008..7013 CDD:409353
Ig strand G 7021..7024 CDD:409353
IG_like 7075..7140 CDD:214653
Ig strand C 7082..7086 CDD:409353
Ig strand E 7107..7111 CDD:409353
Ig strand F 7121..7126 CDD:409353
Ig strand G 7135..7138 CDD:409353
Ig 7173..7232 CDD:409353
Ig strand C 7184..7188 CDD:409353
Ig strand E 7210..7214 CDD:409353
Ig strand F 7224..7229 CDD:409353
IG_like 7406..7475 CDD:214653
Ig strand B 7413..7417 CDD:409353
Ig strand C 7426..7430 CDD:409353
Ig strand E 7451..7455 CDD:409353
Ig strand F 7465..7470 CDD:409353
FN3 7489..7588 CDD:238020
STKc_MLCK 7626..7876 CDD:271005 110/257 (43%)
Blue background indicates that the domain is not in the aligned region.

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