DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAPK1 and dapk1

DIOPT Version :9

Sequence 1:	NP_001275658.1	Gene:	DAPK1 / 1612	HGNCID:	2674	Length:	1430	Species:	Homo sapiens
Sequence 2:	NP_001116911.1	Gene:	dapk1 / 100144678	XenbaseID:	XB-GENE-1011852	Length:	1427	Species:	Xenopus tropicalis

Alignment Length:	1430	Identity:	1236/1430 - (86%)
Similarity:	1346/1430 - (94%)	Gaps:	3/1430 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
            |||||||||:||||.|||||||||||||||:|||||:.||||||||||||||||||:||||||||
Frog     1 MTVFRQENVEDYYDIGEELGSGQFAVVKKCQEKSTGVHYAAKFIKKRRTKSSRRGVTREDIEREV 65

Human    66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
            |||||||||||||||||||||.||||||||||||||||||||||||||||||||:|||||||.||
Frog    66 SILKEIQHPNVITLHEVYENKADVILILELVAGGELFDFLAEKESLTEEEATEFIKQILNGVNYL 130

Human   131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 195
            |||.|||||||||||||||||.|.||||||||||||:||.|||||||||||||||||||||||||
Frog   131 HSLHIAHFDLKPENIMLLDRNAPNPRIKIIDFGLAHRIDSGNEFKNIFGTPEFVAPEIVNYEPLG 195

Human   196 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDP 260
            ||:|||||||||||||||||||||:||||||||:|||:|:||:|:||:||.||||||||||||||
Frog   196 LESDMWSIGVITYILLSGASPFLGETKQETLANISAVSYDFEEEFFSSTSDLAKDFIRRLLVKDP 260

Human   261 KKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSR 325
            ||||||||||.|||||||||||||||||||||||||||||||:||||||||||||||||||||||
Frog   261 KKRMTIQDSLYHPWIKPKDTQQALSRKASAVNMEKFKKFAARRKWKQSVRLISLCQRLSRSFLSR 325

Human   326 SNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCG 390
            ||||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
Frog   326 SNMSIARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLFGSLSNYDVNQPNKHGTPPLLIAAGCG 390

Human   391 NIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARY 455
            |||||:||||||::||||||.||||:|||:|||||:|||||.:|.||||:||||||.||||||||
Frog   391 NIQILELLIKRGAQIDVQDKAGSNAIYWASRHGHVETLKFLHQNNCPLDIKDKSGETALHVAARY 455

Human   456 GHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
            |||:|.|.|||.||:|:|||||||||||||||||||.||||||:|||||||:|||||||:|||:|
Frog   456 GHAEVIQYLCSIGSHPDIQDKEEETPLHCAAWHGYYPVAKALCQAGCNVNIRNREGETPILTAAA 520

Human   521 RGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC 585
            ||||||||||.:||.||:|.|||||||||||||||||||:|||:..|||||:|||||||||||||
Frog   521 RGYHDIVECLVDHGGDLDATDKDGHIALHLAVRRCQMEVVKTLIIHGCFVDFQDRHGNTPLHVAC 585

Human   586 KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
            ||||:|||:|||||.|||||:||||||||||||||||::||||||:.||:|||||.|||||||||
Frog   586 KDGNLPIVMALCEARCNLDITNKYGRTPLHLAANNGIVEVVRYLCVAGANVEALTLDGKTAEDLA 650

Human   651 RSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSF 715
            ||||||.|..||||||:||:|.||||||||:...|||||||||||.|||||||||||||||:|||
Frog   651 RSEQHESVVSLLARLRRDTYRTLFIQQLRPSPTPQPRIKLKLFGHMGSGKTTLVESLKCGLIRSF 715

Human   716 FRRRRPRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP 780
            |||||||||||||||||.|||.:| ||||||::||||||||||||||||||||||||:|||||:|
Frog   716 FRRRRPRLSSTNSSRFPSSPLTAK-TVSVSISDLYPGCENVSVRSRSMMFEPGLTKGVLEVFVSP 779

Human   781 THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVFSLEEP 845
            :  |||..|||||||||||:|.||||||||||||||||.|:|.|||||||||||:|:||||||||
Frog   780 S--PHCYTDDQSTKAIDIQSANLNGVGDFSVWEFSGNPTYYCSYDYFAANDPTSVHIVVFSLEEP 842

Human   846 YEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGGEFGYDKDTSL 910
            ||||||||||||:|||||||||||||:||||||.|.||||||||||:|:||||||||||||..:|
Frog   843 YEIQLNQVIFWLNFLKSLVPVEEPIAYGGKLKNLLHVVLVATHADIVNLPRPAGGEFGYDKSLAL 907

Human   911 LKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCPPMTHLCEKIISTLPS 975
            |||:||||||||.|.::|||||||.||||:||:|||||||:|||::|.|||||.||||::|||||
Frog   908 LKEVRNRFGNDLQILDRLFVLDAGGSGSKEMKLLRNHLQELRSQLISDCPPMTPLCEKVMSTLPS 972

Human   976 WRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGEINIMQSETVQDVLLLDPRWL 1040
            |||.||||||:|||||||||||||||||||||:|.:|.||||.||:|||||||||||:|||||||
Frog   973 WRKQNGPNQLLSLQQFVYDVQDQLNPLASEEDVRNLALQLHSIGEVNIMQSETVQDVVLLDPRWL 1037

Human  1041 CTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEELLQILDAMDICARDLSSGTMVDVPA 1105
            |.||||||||||.|:||||||||||:|||||||.||||:||:||||||||||||||||.|||:||
Frog  1038 CHNVLGKLLSVENPKALHHYRGRYTMEDIQRLVTDSDVDELVQILDAMDICARDLSSGAMVDIPA 1102

Human  1106 LIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQSTEGDADIRLW 1170
            |||||||||||||||:::|:||||||||||||||||||||||||||||||:||||.:||||||||
Frog  1103 LIKTDNLHRSWADEEEDIMIYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWVHQQSADGDADIRLW 1167

Human  1171 VNGCKLANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKH 1235
            |||||:||||||:|||:|||||||||||||||||||||||||:|:||.|:|:.||||||||||||
Frog  1168 VNGCKIANRGAEVLVLMVNHGQGIEVQVRGLETEKIKCCLLLESICSIIDNLFATTLPGLLTVKH 1232

Human  1236 YLSPQQLREHHEPVMIYQPRDFFRAQTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDI 1300
            |||||||||||||:|:||||||||||..|||||.|||.|||||||||:||||.|||||.:||:|.
Frog  1233 YLSPQQLREHHEPLMVYQPRDFFRAQIQKETSLANTMAGYKESFSSILCFGCLDVYSQGNLGLDH 1297

Human  1301 HASDLNLLTRRKLSRLLDPPDPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREW 1365
            |.||:|:|.|||||||||||||:||||||||||||||||||||||:|...|||||||:.|||:||
Frog  1298 HVSDINILVRRKLSRLLDPPDPMGKDWCLLAMNLGLPDLVAKYNTNNSVQKDFLPSPMCALLQEW 1362

Human  1366 TTYPESTVGTLMSKLRELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR 1430
            :..|||||..|||||||||||||||||||||||||:.||.:||||||:|||||||||||||||||
Frog  1363 SNSPESTVSLLMSKLRELGRRDAADFLLKASSVFKVTLDIHGQEAYAASCNSGTSYNSISSVVSR 1427

Human 1431 1430
Frog 1428 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAPK1	NP_001275658.1	STKc_DAPK1	7..275	CDD:271096	243/267 (91%)
		Calmodulin-binding	267..334		63/66 (95%)
		Autoinhibitory domain. /evidence=ECO:0000250	292..301		8/8 (100%)
		ANK	373..497	CDD:238125	104/123 (85%)
		ANK repeat	378..409	CDD:293786	27/30 (90%)
		ANK 1	378..407		25/28 (89%)
		ANK 2	411..440		21/28 (75%)
		ANK repeat	412..442	CDD:293786	22/29 (76%)
		ANK	439..564	CDD:238125	105/124 (85%)
		ANK repeat	444..475	CDD:293786	23/30 (77%)
		ANK 3	444..473		22/28 (79%)
		ANK repeat	477..508	CDD:293786	28/30 (93%)
		ANK 4	477..506		26/28 (93%)
		ANK	505..629	CDD:238125	104/123 (85%)
		ANK repeat	510..541	CDD:293786	24/30 (80%)
		ANK 5	510..539		23/28 (82%)
		Ank_2	<515..768	CDD:330894	212/252 (84%)
		ANK repeat	543..574	CDD:293786	25/30 (83%)
		ANK 6	543..572		24/28 (86%)
		ANK repeat	576..607	CDD:293786	27/30 (90%)
		ANK 7	576..605		25/28 (89%)
		ANK repeat	609..638	CDD:293786	23/28 (82%)
		ANK 8	609..638		23/28 (82%)
		ANK 9	875..904		24/28 (86%)
		ANK 10	1162..1196		29/33 (88%)
		Death_DAPK1	1308..1393	CDD:260052	70/84 (83%)
dapk1	NP_001116911.1	STKc_DAPK1	7..275	CDD:271096	243/267 (91%)
		Ank_2	<338..409	CDD:423045	66/70 (94%)
		ANK repeat	378..409	CDD:293786	27/30 (90%)
		Ank_4	379..432	CDD:372654	45/52 (87%)
		ANK repeat	412..442	CDD:293786	22/29 (76%)
		Ank_2	425..>639	CDD:423045	177/213 (83%)
		ANK repeat	444..475	CDD:293786	23/30 (77%)
		ANK repeat	477..508	CDD:293786	28/30 (93%)
		ANK repeat	510..541	CDD:293786	24/30 (80%)
		ANK repeat	543..574	CDD:293786	25/30 (83%)
		ANK repeat	576..607	CDD:293786	27/30 (90%)
		ANK repeat	609..638	CDD:293786	23/28 (82%)
		Death_DAPK1	1305..1390	CDD:260052	70/84 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1172	1.000	Domainoid score	I431
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H3626
Inparanoid	1	1.050	2545	1.000	Inparanoid score	I379
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14681at32523
OrthoFinder	1	1.000	-	-		FOG0009189
OrthoInspector	1	1.000	-	-		oto154014
Panther	1	1.100	-	-	LDO	PTHR24342
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6927
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.160