Protein Alignment DAPK1 and dapk1

DIOPT Version :10

• Sequence 1: NP_004929.2
• Gene: DAPK1 / 1612
• HGNCID: 2674
• Length: 1430
• Species: Homo sapiens
• Sequence 2: NP_001116911.1
• Gene: dapk1 / 100144678
• XenbaseID: XB-GENE-1011852
• Length: 1427
• Species: Xenopus tropicalis
• Alignment Length: 1430
• Identity: 1236/1430 - (86%)
• Similarity: 1346/1430 - (94%)
• Gaps: 3/1430 - (0%)

Human     1 MTVFRQENVDDYYDTGEELGSGQFAVVKKCREKSTGLQYAAKFIKKRRTKSSRRGVSREDIEREV 65
            |||||||||:||||.|||||||||||||||:|||||:.||||||||||||||||||:||||||||
 Frog     1 MTVFRQENVEDYYDIGEELGSGQFAVVKKCQEKSTGVHYAAKFIKKRRTKSSRRGVTREDIEREV 65

Human    66 SILKEIQHPNVITLHEVYENKTDVILILELVAGGELFDFLAEKESLTEEEATEFLKQILNGVYYL 130
            |||||||||||||||||||||.||||||||||||||||||||||||||||||||:|||||||.||
 Frog    66 SILKEIQHPNVITLHEVYENKADVILILELVAGGELFDFLAEKESLTEEEATEFIKQILNGVNYL 130

Human   131 HSLQIAHFDLKPENIMLLDRNVPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLG 195
            |||.|||||||||||||||||.|.||||||||||||:||.|||||||||||||||||||||||||
 Frog   131 HSLHIAHFDLKPENIMLLDRNAPNPRIKIIDFGLAHRIDSGNEFKNIFGTPEFVAPEIVNYEPLG 195

Human   196 LEADMWSIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDFIRRLLVKDP 260
            ||:|||||||||||||||||||||:||||||||:|||:|:||:|:||:||.||||||||||||||
 Frog   196 LESDMWSIGVITYILLSGASPFLGETKQETLANISAVSYDFEEEFFSSTSDLAKDFIRRLLVKDP 260

Human   261 KKRMTIQDSLQHPWIKPKDTQQALSRKASAVNMEKFKKFAARKKWKQSVRLISLCQRLSRSFLSR 325
            ||||||||||.|||||||||||||||||||||||||||||||:||||||||||||||||||||||
 Frog   261 KKRMTIQDSLYHPWIKPKDTQQALSRKASAVNMEKFKKFAARRKWKQSVRLISLCQRLSRSFLSR 325

Human   326 SNMSVARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCG 390
            ||||:|||||||||||||||||||||||||||||||||.||||||||||||||||||||||||||
 Frog   326 SNMSIARSDDTLDEEDSFVMKAIIHAINDDNVPGLQHLFGSLSNYDVNQPNKHGTPPLLIAAGCG 390

Human   391 NIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARY 455
            |||||:||||||::||||||.||||:|||:|||||:|||||.:|.||||:||||||.||||||||
 Frog   391 NIQILELLIKRGAQIDVQDKAGSNAIYWASRHGHVETLKFLHQNNCPLDIKDKSGETALHVAARY 455

Human   456 GHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASA 520
            |||:|.|.|||.||:|:|||||||||||||||||||.||||||:|||||||:|||||||:|||:|
 Frog   456 GHAEVIQYLCSIGSHPDIQDKEEETPLHCAAWHGYYPVAKALCQAGCNVNIRNREGETPILTAAA 520

Human   521 RGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVAC 585
            ||||||||||.:||.||:|.|||||||||||||||||||:|||:..|||||:|||||||||||||
 Frog   521 RGYHDIVECLVDHGGDLDATDKDGHIALHLAVRRCQMEVVKTLIIHGCFVDFQDRHGNTPLHVAC 585

Human   586 KDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLA 650
            ||||:|||:|||||.|||||:||||||||||||||||::||||||:.||:|||||.|||||||||
 Frog   586 KDGNLPIVMALCEARCNLDITNKYGRTPLHLAANNGIVEVVRYLCVAGANVEALTLDGKTAEDLA 650

Human   651 RSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQNLQPRIKLKLFGHSGSGKTTLVESLKCGLLRSF 715
            ||||||.|..||||||:||:|.||||||||:...|||||||||||.|||||||||||||||:|||
 Frog   651 RSEQHESVVSLLARLRRDTYRTLFIQQLRPSPTPQPRIKLKLFGHMGSGKTTLVESLKCGLIRSF 715

Human   716 FRRRRPRLSSTNSSRFPPSPLASKPTVSVSINNLYPGCENVSVRSRSMMFEPGLTKGMLEVFVAP 780
            |||||||||||||||||.|||.:| ||||||::||||||||||||||||||||||||:|||||:|
 Frog   716 FRRRRPRLSSTNSSRFPSSPLTAK-TVSVSISDLYPGCENVSVRSRSMMFEPGLTKGVLEVFVSP 779

Human   781 THHPHCSADDQSTKAIDIQNAYLNGVGDFSVWEFSGNPVYFCCYDYFAANDPTSIHVVVFSLEEP 845
            :  |||..|||||||||||:|.||||||||||||||||.|:|.|||||||||||:|:||||||||
 Frog   780 S--PHCYTDDQSTKAIDIQSANLNGVGDFSVWEFSGNPTYYCSYDYFAANDPTSVHIVVFSLEEP 842

Human   846 YEIQLNQVIFWLSFLKSLVPVEEPIAFGGKLKNPLQVVLVATHADIMNVPRPAGGEFGYDKDTSL 910
            ||||||||||||:|||||||||||||:||||||.|.||||||||||:|:||||||||||||..:|
 Frog   843 YEIQLNQVIFWLNFLKSLVPVEEPIAYGGKLKNLLHVVLVATHADIVNLPRPAGGEFGYDKSLAL 907

Human   911 LKEIRNRFGNDLHISNKLFVLDAGASGSKDMKVLRNHLQEIRSQIVSVCPPMTHLCEKIISTLPS 975
            |||:||||||||.|.::|||||||.||||:||:|||||||:|||::|.|||||.||||::|||||
 Frog   908 LKEVRNRFGNDLQILDRLFVLDAGGSGSKEMKLLRNHLQELRSQLISDCPPMTPLCEKVMSTLPS 972

Human   976 WRKLNGPNQLMSLQQFVYDVQDQLNPLASEEDLRRIAQQLHSTGEINIMQSETVQDVLLLDPRWL 1040
            |||.||||||:|||||||||||||||||||||:|.:|.||||.||:|||||||||||:|||||||
 Frog   973 WRKQNGPNQLLSLQQFVYDVQDQLNPLASEEDVRNLALQLHSIGEVNIMQSETVQDVVLLDPRWL 1037

Human  1041 CTNVLGKLLSVETPRALHHYRGRYTVEDIQRLVPDSDVEELLQILDAMDICARDLSSGTMVDVPA 1105
            |.||||||||||.|:||||||||||:|||||||.||||:||:||||||||||||||||.|||:||
 Frog  1038 CHNVLGKLLSVENPKALHHYRGRYTMEDIQRLVTDSDVDELVQILDAMDICARDLSSGAMVDIPA 1102

Human  1106 LIKTDNLHRSWADEEDEVMVYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWIHQQSTEGDADIRLW 1170
            |||||||||||||||:::|:||||||||||||||||||||||||||||||:||||.:||||||||
 Frog  1103 LIKTDNLHRSWADEEEDIMIYGGVRIVPVEHLTPFPCGIFHKVQVNLCRWVHQQSADGDADIRLW 1167

Human  1171 VNGCKLANRGAELLVLLVNHGQGIEVQVRGLETEKIKCCLLLDSVCSTIENVMATTLPGLLTVKH 1235
            |||||:||||||:|||:|||||||||||||||||||||||||:|:||.|:|:.||||||||||||
 Frog  1168 VNGCKIANRGAEVLVLMVNHGQGIEVQVRGLETEKIKCCLLLESICSIIDNLFATTLPGLLTVKH 1232

Human  1236 YLSPQQLREHHEPVMIYQPRDFFRAQTLKETSLTNTMGGYKESFSSIMCFGCHDVYSQASLGMDI 1300
            |||||||||||||:|:||||||||||..|||||.|||.|||||||||:||||.|||||.:||:|.
 Frog  1233 YLSPQQLREHHEPLMVYQPRDFFRAQIQKETSLANTMAGYKESFSSILCFGCLDVYSQGNLGLDH 1297

Human  1301 HASDLNLLTRRKLSRLLDPPDPLGKDWCLLAMNLGLPDLVAKYNTSNGAPKDFLPSPLHALLREW 1365
            |.||:|:|.|||||||||||||:||||||||||||||||||||||:|...|||||||:.|||:||
 Frog  1298 HVSDINILVRRKLSRLLDPPDPMGKDWCLLAMNLGLPDLVAKYNTNNSVQKDFLPSPMCALLQEW 1362

Human  1366 TTYPESTVGTLMSKLRELGRRDAADFLLKASSVFKINLDGNGQEAYASSCNSGTSYNSISSVVSR 1430
            :..|||||..|||||||||||||||||||||||||:.||.:||||||:|||||||||||||||||
 Frog  1363 SNSPESTVSLLMSKLRELGRRDAADFLLKASSVFKVTLDIHGQEAYAASCNSGTSYNSISSVVSR 1427

Human  1431  1430
             Frog  1428  1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAPK1	NP_004929.2	STKc_DAPK1	7..275	CDD:271096	243/267 (91%)
		Calmodulin-binding	267..334		63/66 (95%)
		Autoinhibitory domain. /evidence=ECO:0000250	292..301		8/8 (100%)
		Ank_2	<338..409	CDD:463710	66/70 (94%)
		ANK repeat	378..409	CDD:293786	27/30 (90%)
		ANK 1	378..407		25/28 (89%)
		ANKYR	392..668	CDD:440430	229/275 (83%)
		ANK 2	411..440		21/28 (75%)
		ANK repeat	412..442	CDD:293786	22/29 (76%)
		ANK repeat	444..475	CDD:293786	23/30 (77%)
		ANK 3	444..473		22/28 (79%)
		ANK repeat	477..508	CDD:293786	28/30 (93%)
		ANK 4	477..506		26/28 (93%)
		ANK repeat	510..541	CDD:293786	24/30 (80%)
		ANK 5	510..539		23/28 (82%)
		ANK repeat	543..574	CDD:293786	25/30 (83%)
		ANK 6	543..572		24/28 (86%)
		ANK repeat	576..607	CDD:293786	27/30 (90%)
		ANK 7	576..605		25/28 (89%)
		ANK repeat	609..638	CDD:293786	23/28 (82%)
		ANK 8	609..638		23/28 (82%)
		ANK 9	875..904		24/28 (86%)
		ANK 10	1162..1196		29/33 (88%)
		Death_DAPK1	1308..1393	CDD:260052	70/84 (83%)
dapk1	NP_001116911.1	STKc_DAPK1	7..275	CDD:271096	243/267 (91%)
		Ank_2	<338..409	CDD:463710	66/70 (94%)
		ANK repeat	378..409	CDD:293786	27/30 (90%)
		ANKYR	392..668	CDD:440430	229/275 (83%)
		ANK repeat	412..442	CDD:293786	22/29 (76%)
		ANK repeat	444..475	CDD:293786	23/30 (77%)
		ANK repeat	477..508	CDD:293786	28/30 (93%)
		ANK repeat	510..541	CDD:293786	24/30 (80%)
		ANK repeat	543..574	CDD:293786	25/30 (83%)
		ANK repeat	576..607	CDD:293786	27/30 (90%)
		ANK repeat	609..638	CDD:293786	23/28 (82%)
		Death_DAPK1	1305..1390	CDD:260052	70/84 (83%)