DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLEC14A and egas-4

DIOPT Version :9

Sequence 1:	NP_778230.1	Gene:	CLEC14A / 161198	HGNCID:	19832	Length:	490	Species:	Homo sapiens
Sequence 2:	NP_501207.2	Gene:	egas-4 / 3564809	WormBaseID:	WBGene00018906	Length:	883	Species:	Caenorhabditis elegans

Alignment Length:	148	Identity:	41/148 - (27%)
Similarity:	54/148 - (36%)	Gaps:	36/148 - (24%)

- Green bases have known domain annotations that are detailed below.

Human   166 ANGYLCKYQFEVLC-PAPRPGA-------ASNLSYRAPFQLHSAALDFSP-PGTEVSALCR--GQ 219
            |:||         | ||.|..|       .|:.|.:......:|....|| |.|..:..|.  ..
Worm    23 AHGY---------CYPANRTSATTCSECTCSDESTQTSDTTCTAPTSCSPNPCTLSNQQCNMVND 78

Human   220 LPISVTCIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGR 284
            :| :.||.....|.....|:.|...|.|        |.:...|....|.::|.|||||    .|.
Worm    79 IP-TCTCAVGYTGTDCTMLTSDPCSPQP--------CLQNGVCSSSGGTYSCACATGF----FGE 130

Human   285 SCVTSGE---GQPTLGGT 299
            .|..||:   |..:.|||
Worm   131 QCQYSGDPCSGYCSNGGT 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLEC14A	NP_778230.1	CLECT_thrombomodulin_like	32..175	CDD:153070	3/8 (38%)
		FXa_inhibition	254..286	CDD:291342	10/31 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..349		7/17 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..461
egas-4	NP_501207.2	EGF	101..131	CDD:278437	12/41 (29%)
		EGF_CA	482..522	CDD:238011
		ASC	<610..869	CDD:279230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161463604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930