DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLEC14A and R05G6.9

DIOPT Version :9

Sequence 1:	NP_778230.1	Gene:	CLEC14A / 161198	HGNCID:	19832	Length:	490	Species:	Homo sapiens
Sequence 2:	NP_501215.2	Gene:	R05G6.9 / 187624	WormBaseID:	WBGene00019901	Length:	378	Species:	Caenorhabditis elegans

Alignment Length:	182	Identity:	42/182 - (23%)
Similarity:	59/182 - (32%)	Gaps:	43/182 - (23%)

- Green bases have known domain annotations that are detailed below.

Human   116 LSSDPGGLESDTLQWVEEPQRSCTARRCAVLQATGGVEPAGWKE---MRCHLRANGYLCKYQFEV 177
            |.::|.||:.|.|:       .|||..|     .|.....|.|:   ..|:|...|:.|:.:...
Worm   113 LLNNPFGLDDDALE-------MCTASDC-----NGNGVCVGSKKAPLCLCNLGKTGFKCESEISG 165

Human   178 LCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRG-QLPISVTCIADEIGARWDKLSGD 241
            |.         |:...||...      .||.......||.| :...|..|.....|:|.:|..
Worm   166 LL---------NMDPSAPITF------CSPSDCNNKGLCLGTKNSFSCACQIGYTGSRCEKTP-- 213

Human   242 VLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGK----DGRSCVTS 289
             :..|..|     .|:....|:.......|.|..|:...|    .|..|..|
Worm   214 -VALCDSR-----DCSSNGLCIGTKDSMTCACYLGYSGDKCEKITGTMCEAS 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLEC14A	NP_778230.1	CLECT_thrombomodulin_like	32..175	CDD:153070	17/61 (28%)
		FXa_inhibition	254..286	CDD:291342	7/35 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..349		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..461
R05G6.9	NP_501215.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161463602
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930