DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLEC14A and thbd

DIOPT Version :9

Sequence 1:	NP_778230.1	Gene:	CLEC14A / 161198	HGNCID:	19832	Length:	490	Species:	Homo sapiens
Sequence 2:	XP_012818722.2	Gene:	thbd / 100485229	XenbaseID:	XB-GENE-967380	Length:	541	Species:	Xenopus tropicalis

Alignment Length:	281	Identity:	76/281 - (27%)
Similarity:	116/281 - (41%)	Gaps:	51/281 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    36 ACYSLHHATMKRQAAEEACILRGGALSTVRAGAELRAVLALLRAGPGPGG--GSKDLLFWVALER 98
            :||.....:.:.:.||..|...||.|..||:..|...:..|:       |  |.|....|:.||
Frog    36 SCYLGVWNSKRYKKAERQCTELGGNLMAVRSSVEAEVIEMLM-------GKLGDKVASVWIGLE- 92

Human    99 RRSHCTLENEPLRGFSWLSSDPGGLESDT--LQWVEEPQRSCTARRCAVLQATGGVEPAGWKEMR 161
            .|..||..:.|||||.|::.     ||:|  ..| :..:|.| ...|.|:.     :...|:|..
Frog    93 LRGQCTDISLPLRGFQWVTG-----ESNTNYSNW-KSNERKC-GNLCVVVH-----KDLSWEEAV 145

Human   162 CHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTE-------VSALCRGQ 219
            |..:.:||||:..:...|.........:::|..|..:....:.|.||||:       :|.:|..|
Frog   146 CDSKTDGYLCEIPYSASCQPIYFPQGLDVTYETPLGMAGPGITFLPPGTKAVIPSAHLSLVCEDQ 210

Human   220 LPISVTCIADEIGARWDKL----------SGDV---LCPC-PGRYLR--AGKCAELPN---CLDD 265
            ....:...:::.|| |:.:          :||.   .|.| |...|.  ...|..||:   |:.|
Frog   211 GDGEMKWTSEDYGA-WNCMIENGGCSFICNGDTEGSRCECGPNTNLSDDGRSCMPLPSSLQCIPD 274

Human   266 LGGFACECATGFELGKDGRSC 286
            .....|.||.||.|.:||.:|
Frog   275 QSTGTCVCAEGFALAEDGMTC 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLEC14A	NP_778230.1	CLECT_thrombomodulin_like	32..175	CDD:153070	42/142 (30%)
		FXa_inhibition	254..286	CDD:291342	13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..349		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..461
thbd	XP_012818722.2	CLECT	32..156	CDD:413318	41/139 (29%)
		FXa_inhibition	227..262	CDD:405372	6/34 (18%)
		cEGF	279..299	CDD:403760	9/17 (53%)
		EGF_CA	297..>327	CDD:214542
		EGF_CA	336..>366	CDD:419698
		vWFA	<414..451	CDD:412136
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910