Protein Alignment AP2A2 and AP-2alpha

DIOPT Version :10

• Sequence 1: NP_001229766.1
• Gene: AP2A2 / 161
• HGNCID: 562
• Length: 940
• Species: Homo sapiens
• Sequence 2: NP_995607.1
• Gene: AP-2alpha / 33211
• FlyBaseID: FBgn0264855
• Length: 952
• Species: Drosophila melanogaster
• Alignment Length: 936
• Identity: 644/936 - (68%)
• Similarity: 753/936 - (80%)
• Gaps: 35/936 - (3%)

Human    23 CKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNR 87
            |||||||:||||||||||||||||||.||||.||||||||||||||||||||||||||||||||:
  Fly    34 CKSKEAEVKRINKELANIRSKFKGDKTLDGYQKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSNK 98

Human    88 YTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEAFAGEIP 152
            |:||||||||||||||:||:|||||..:|||||.||||..:.|||.|||::|||:|||:|:.|||
  Fly    99 YSEKQIGYLFISVLVNTNSDLIRLIIQSIKNDLQSRNPVHVNLALQCIANIGSRDMAESFSNEIP 163

Human   153 KVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQHLGVVTAATSLITTLAQK 217
            |:||:|||||.||||||||||||:|:|||::|.|:||||::|||||||:||||||||||..|.::
  Fly   164 KLLVSGDTMDVVKQSAALCLLRLFRSSPDIIPGGEWTSRIIHLLNDQHMGVVTAATSLIDALVKR 228

Human   218 NPEEFKTSVSLAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRLLQCY-PPPEDPAVRGRLT 281
            ||:|:|..|:|||||||||||::.|||||||||||||||||||||||||.| |..|:..||.||.
  Fly   229 NPDEYKGCVNLAVSRLSRIVTASYTDLQDYTYYFVPAPWLSVKLLRLLQNYNPVTEEAGVRARLN 293

Human   282 ECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISLIIHHDSEPNLLVRACNQLGQFLQHRETNLR 346
            |.|||||||||||||||||||||||||||||||:||||.||||||||||||||||||.:||||||
  Fly   294 ETLETILNKAQEPPKSKKVQHSNAKNAVLFEAINLIIHSDSEPNLLVRACNQLGQFLSNRETNLR 358

Human   347 YLALESMCTLASSEFSHEAVKTHIETVINALKTERDVSVRQRAVDLLYAMCDRSNAPQIVAEMLS 411
            ||||||||.||:||||||.||.|.|.||.::|.|:||||||.|||||||||||.||.:||.|||:
  Fly   359 YLALESMCHLATSEFSHEEVKKHQEVVILSMKMEKDVSVRQMAVDLLYAMCDRGNAEEIVQEMLN 423

Human   412 YLETADYSIREEIVLKVAILAEKYAVDYTWYVDTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQ 476
            ||||||||||||:||||||||||||.|||||||.|||||||||||||||||||||||||||::||
  Fly   424 YLETADYSIREEMVLKVAILAEKYATDYTWYVDVILNLIRIAGDYVSEEVWYRVIQIVINREEVQ 488

Human   477 GYAAKTVFEALQAPACHENLVKVGGYILGEFGNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALL 541
            |||||||||||||||||||:||||||||||||||||||.||:||:||.|||||:||||..|||||
  Fly   489 GYAAKTVFEALQAPACHENMVKVGGYILGEFGNLIAGDSRSAPLVQFKLLHSKYHLCSPMTRALL 553

Human   542 LSTYIKFVNLFPEVKPTIQDVLRSDSQLRNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFP 606
            |||||||:|||||::..||||.|..|.||:||.||||||.|||:||.|||||:|||||||||.||
  Fly   554 LSTYIKFINLFPEIRTNIQDVFRQHSNLRSADAELQQRASEYLQLSIVASTDVLATVLEEMPSFP 618

Human   607 ERESSILAKLKKKKGPSTVTDLEDTKRDRSVDVNGGPEPAPASTSA------------VSTPSPS 659
            ||||||||.||||| |..|.:.|         :.....|||.:::|            ::..:.:
  Fly   619 ERESSILAVLKKKK-PGRVPENE---------IRESKSPAPLTSAAQNNALVNNSHSKLNNSNAN 673

Human   660 ADLLGLGAAPPAPAGPPPSSGGSG-----LLVDVFSDSASVVAPLAPGSEDNFARFVCKNNGVLF 719
            .|||||..       ||.::.|||     .|:||..|.....:.....:..|..:|:.|||||||
  Fly   674 TDLLGLST-------PPSNNIGSGSNSNSTLIDVLGDMYGSNSNNNSSAVYNTKKFLFKNNGVLF 731

Human   720 ENQLLQIGLKSEFRQNLGRMFIFYGNKTSTQFLNFTPTLICSDDLQPNLNLQTKPVDPTVEGGAQ 784
            ||::||||:||||||||||:.:||||||.....||.|.|..|.:....||:|.|.|:||:|.|||
  Fly   732 ENEMLQIGVKSEFRQNLGRLGLFYGNKTQVPLTNFNPVLQWSAEDALKLNVQMKVVEPTLEAGAQ 796

Human   785 VQQVVNIECVSDFTEAPVLNIQFRYGGTFQNVSVQLPITLNKFFQPTEMASQDFFQRWKQLSNPQ 849
            :||::..||:.|:.:||.:.|.|||.||.|..|::||:::||||:||||.::.||.|||.||..|
  Fly   797 IQQLLTAECIEDYADAPTIEISFRYNGTQQKFSIKLPLSVNKFFEPTEMNAESFFARWKNLSGEQ 861

Human   850 QEVQNIFKAKHPMDTEVTKAKIIGFGSALLEEVDPNPANFVGAGIIHTKTTQIGCLLRLEPNLQA 914
            |..|.:|||..|:|....:.|::|||..||::|||||.|.|.||||||::.|:|||:|||||.||
  Fly   862 QRSQKVFKAAQPLDLPGARNKLMGFGMQLLDQVDPNPDNMVCAGIIHTQSQQVGCLMRLEPNKQA 926

Human   915 QMYRLTLRTSKEAVSQRLCELLSAQF 940
            ||:|||:|.|||.|::.:|:||:.||
  Fly   927 QMFRLTVRASKETVTREICDLLTDQF 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP2A2	NP_001229766.1	Adaptin_N	29..591	CDD:396262	457/562 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..682		21/80 (26%)
		Alpha_adaptinC2	718..821	CDD:197886	55/102 (54%)
		Alpha_adaptin_C	827..935	CDD:426707	62/107 (58%)
AP-2alpha	NP_995607.1	Adaptin_N	40..603	CDD:396262	457/562 (81%)
		Alpha_adaptinC2	730..839	CDD:197886	58/108 (54%)
		Alpha_adaptin_C	839..947	CDD:426707	62/107 (58%)