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Protein Alignment AP2A2 and AP-1gamma

DIOPT Version :9

Sequence 1:	NP_001229766.1	Gene:	AP2A2 / 161	HGNCID:	562	Length:	940	Species:	Homo sapiens
Sequence 2:	NP_788891.2	Gene:	AP-1gamma / 31842	FlyBaseID:	FBgn0030089	Length:	982	Species:	Drosophila melanogaster

Alignment Length:	781	Identity:	204/781 - (26%)
Similarity:	356/781 - (45%)	Gaps:	137/781 - (17%)

- Green bases have known domain annotations that are detailed below.

Human     1 MPAVSKGDGMRGLAVFISDIRNCKSKEAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFI 65
            ||..::   :|.|   |..||..::...|...:|||.|.|||.|:.:   |...:.:.:.|||:|
  Fly    42 MPTPTR---LRDL---IRQIRAARTAAEERAVVNKECAYIRSTFREE---DSVWRCRNIAKLLYI 97

Human    66 FLLGHDIDFGHMEAVNLLSSNRYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGL 130
            .:||:...||.:|.:.|.:|.|:|:|:||||...:|::...::..||.|.:||||.|.....:||
  Fly    98 HMLGYPAHFGQLECLKLTASTRFTDKRIGYLGAMLLLDERQDVHLLITNCLKNDLNSSTQFVVGL 162

Human   131 ALHCIASVGSREMAEAFAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHL 195
            ||..:.::.|.|||...|.|:.:::.:.:|.  :::.|.||..|:.|..|:|:.:  :......|
  Fly   163 ALCTLGAIASPEMARDLASEVERLMKSPNTY--IRKKATLCAFRVIRRVPELMEI--FLPATRSL 223

Human   196 LNDQHLGVVTAATSLITTLAQKNPE---EFKTS------VSLAVSRLSRIVTSASTDLQDYTYYF 251
            |::::.|::....:|||.:.:.:.:   .||..      |...|..|..::....:...|.:  .
  Fly   224 LSEKNHGILITGVTLITEMCENSSDTLMHFKKDSGNREIVPNLVRILKNLILGGYSPEHDVS--G 286

Human   252 VPAPWLSVKLLRLLQCYPPPEDPAVRGRLTECLETILNKAQEPPKSKKVQHSNAKNAVLFEAISL 316
            |..|:|.||:||||:.....:..|     :|.:..||.:.....::.|    |..|.:|:|.:..
  Fly   287 VSDPFLQVKILRLLRILGHNDPDA-----SEAMNDILAQVATNTETSK----NVGNTILYETVLS 342

Human   317 IIHHDSEPNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTER 381
            |:...||..|.|.|.|.||:||.:.:.|:||:||.::.....::.|  ||:.|..|::..|| :.
  Fly   343 IMDIRSEGGLRVLAVNILGRFLLNSDKNIRYVALNTLLRTVHADTS--AVQRHRTTILECLK-DP 404

Human   382 DVSVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYVDTI 446
            |||:|:||::|.:|:.:..|...:..|:|.:||.||...:.:....:.:.||:|:....|::||.
  Fly   405 DVSIRRRAMELSFALINAQNIRTMTKELLLFLEKADAEFKAQCSSGMILAAERYSPTTRWHLDTQ 469

Human   447 LNLIRIAGDYVSEEVWYRVIQIVINRD-DVQGYAAKTVFEALQ-APACHEN--LVKVGGYILGEF 507
            |:::..||:||.::|....||:|.:.. ..|.|.....:|:|| |..|.:.  |::|..:.:||:
  Fly   470 LSVLIAAGNYVRDDVVSSTIQLVSSSPVPEQTYITNRFWESLQVANHCEDKQPLLQVAVWAIGEY 534

Human   508 GNLIAGDPRSSPLIQFHLLHSKFHLCSVPTRALLLSTYIKFVNLFPEVKPTIQDVLRSDSQL--- 569
            |:          |..:.....:|..   ||.:.|::.|.||:........:.|..|.|.::|
  Fly   535 GD----------LFMYGANEDEFER---PTESDLIAVYYKFLTSAQVSTTSKQYALVSLAKLSTR 586

Human   570 ----------------RNADVELQQRAVEYLRLSTVASTDILATVLEEMPPFPERESSI-LAKLK 617
                            .:.:|:||||.||:        |.:........||..|:..:: ::::.
  Fly   587 LQQCVEEIQALITSFGSHLNVDLQQRGVEF--------TQLFGHYKHLRPPLLEKMPAMQISRIS 643

Human   618 KKKGPSTVTDLEDTKRD-----------------------------------RSVDVN-GGPEPA 646
            .:.|.|.....:|...|                                   .|.|:: ||....
  Fly   644 SQNGESGGGSFDDNSPDVIENGVEGGGGGGHSLIESNMNTLGDNTNILLDLLGSTDLSAGGAGDL 708

Human   647 PAST------------------SAVSTPSPSADLLGLGAAPPA--PAGPPPSSGGSGLLVDVFSD 691
            .|:|                  :.||......|||.|..:.|:  ..|.|...||.|.:|.:..|
  Fly   709 VAATDLSNAVHKKNSRNANDVVAPVSNNQDLLDLLDLDLSAPSSTTTGAPAGGGGGGGIVALVGD 773

Human   692 S 692
            :
  Fly   774 N 774

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.